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Le Grand Serum

Biologique Recherche

Le Grand Serum

Biologique Recherche
Benefits
  • Anti-Ageing
  • Repairing
  • Firming
  • Plumping
  • Brightening
  • Anti-Wrinkle
  • Antioxidant
  • Hydrating
  • Anti-Inflammatory
The Biologique Recherche Le Grand Serum is a powerful anti-aging face oil. Its luxurious blend of 27 active ingredients slows cell ageing, protects, firms, and regenerates the skin, restoring radiance for a youthful complexion.
Read more
The Biologique Recherche Le Grand Serum is a powerful anti-aging face oil. Its luxurious blend of 27 active ingredients slows cell ageing, protects, firms, and regenerates the skin, restoring radiance for a youthful complexion.
Read less

30 ml

£660
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More Info

  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
Who it is for
Green tick
For you if

Oil for Oily Tendency Skin

Dry Skin

Pigmented Skin

Dull Skin

Wrinkles

Loss of Firmness

Volume Loss

Red Cross
Not For you if

Active Acne

Sensitive Skin

Reactive Skin

Rosacea


Not sure? Consult an expert.

How to Apply
Apply a few drops of Le Grand Sérum to the entire face, neck and décolleté in the morning and/or in the evening. Alternatively, a few drops can also be mixed into your cream.
Ingredients

Scroll down the page for a full breakdown of the active ingredients.

Water (Aqua), Propylene Glycol, Glycerin, Propanediol, Maltodextrin, Hydrolyzed Hazelnut Protein, Lactobacillus/Wasabia Japonica Root Ferment Extract, Pentylene Glycol, Myrtus Communis Leaf Extract, Allium Cepa (Onion) Bulb Extract, Commiphora Myrrha Resin Extract, Honey Extract (Mel Extract), Camellia Sinensis Leaf Extract, Hamamelis Virginiana (Witch Hazel) Bark/Leaf Extract, Centella Asiatica Extract, Hypericum Perforatum Flower/Leaf/Stem Extract, Punica Granatum Pericarp Extract, Haematococcus Pluvialis Extract, Hydrolyzed Soy Protein, Hydrolyzed Yeast Protein, Yeast Extract, Saccharomyces Cerevisiae Extract, Biosaccharide Gum-1, Acetyl Hexapeptide-8, Niacinamide, Sodium Hyaluronate, Lactic Acid, Sodium Lactate, Citric Acid, Allantoin, Serine, Royal Jelly Extract, Carum Carvi (Caraway) Seed Oil, Mentha Piperita (Peppermint) Oil, Acacia Senegal Gum, Xanthan Gum, Caramel, Sorbitol, Lecithin, 1,2-Hexanediol, Tea-Lactate, Urea, Phenylpropanol, Phenoxyethanol, Caprylyl Glycol, Sodium Benzoate, Potassium Sorbate, Limonene.

*This product contains nut-derived ingredients and should be avoided by individuals with nut allergies.


Please note: The ingredients listed in this product are subject to change as the formulation is updated. We aim to update the INCI list as soon as possible, but we encourage you to read the ingredient list on the product itself to ensure it's suitable for your personal use.

Smell & Texture

Smells Like: A neutral scent with hints of botanical notes.

Texture: Light, fluid, and easily absorbed.

About the Brand
Brand logo
Founded in Paris in the late 1970s by biologist Yvan Allouche and physiotherapist Josette Allouche, Biologique Recherche began as a laboratory for bespoke, high-performance formulas for elite skin professionals. Their medical-grade precision and artisanal formulation, paired with consummate savoir-faire, underpin their reputation for outstanding, clinically proven results.

Biologique Recherche treats skin according to its Skin Instant©, the skin’s precise, evolving state. Each formula is loaded with active ingredients in exceptional concentrations, then prescribed to address those real-time needs. This precision approach corrects imbalances, restores function, and delivers visible, lasting transformation.

Cold-processed actives are the core of Biologique Recherche. Formulated at 18–25°C, this method avoids the 70°C heat of standard processing that breaks down actives. Botanical, marine, and biotechnological extracts stay intact for higher absorption, stronger repair, and better tolerance. Antioxidants, peptides, and enzymes remain stable, ensuring consistent, visible results.

The Benefits

  • - + Anti-Ageing (Epigenetics)
  • - + Anti-Wrinkle
  • - + Firming
  • - + Plumping
  • - + Brightening
  • - + Repairing
  • - + Antioxidant
  • - + Hydrating
  • - + Anti-Inflammatory
Anti-Ageing (Epigenetics)

The breakthrough in anti-ageing skincare leverages the power of epigenetic factors—molecules that influence gene expression without altering DNA sequences. These molecules act like responsive switches, turning certain genes on or off in response to environmental cues and lifestyle choices, thereby dynamically adapting the skin's behaviour to external factors. Recent innovations in anti-ageing products harness epigenetic science by incorporating active ingredients that target these factors directly. By promoting gene expressions that support collagen synthesis, cellular regeneration, and antioxidant defences, these formulas effectively combat skin ageing. They visibly reduce fine lines, wrinkles, and dark spots while enhancing skin texture, elasticity, and radiance. This advanced approach addresses not only visible signs but also the underlying causes of skin ageing for comprehensive rejuvenation.

Anti-Wrinkle

Anti-wrinkle products work to smooth out fine lines and wrinkles by boosting collagen and elastin, essential proteins that keep your skin glowing. Collagen helps reduce wrinkle depth, while elastin shortens their length. Keeping your skin hydrated is crucial, as dehydration can make wrinkles more noticeable. For smooth, bouncy skin, ensure you stay well-hydrated and use products that promote collagen and elastin production.

Firming

Skin firming focuses on boosting your skin's elasticity and tightness to reduce sagging and wrinkles, leaving your skin looking firmer. This is done by stimulating fibroblasts to produce more elastin, the protein that helps your skin stretch and bounce back. To keep your skin firm longer, antioxidants protect these elastin fibres from free radical damage, which can cause early breakdown. This combined action helps maintain a youthful, resilient complexion.

Plumping

Skin plumping involves using active ingredients to boost the production of key structural components like collagen, the dermal-epidermal junction, and glycosaminoglycans (GAGs), giving your skin more volume and density. Collagen provides structural support and firmness, while the dermal-epidermal junction, a thin connective layer, ensures smooth, wrinkle-free skin by facilitating cell communication. GAGs, like hyaluronic acid, keep your skin hydrated and plump from within. By stimulating these components, active ingredients help restore your skin's plumpness and radiance.

Brightening

Brightening your skin means restoring its natural glow. One of the best ways to do this is through exfoliation. By exfoliating, you promote faster skin cell turnover, replacing old, damaged cells with fresh, radiant ones. This keeps your skin looking vibrant and healthy.

Repairing

Repairing your skin means restoring cells damaged by external factors like UV rays and free radicals, which can harm cell DNA and slow regeneration. Although our cells naturally repair themselves, this ability weakens over time due to ageing and repeated environmental exposure. Active ingredients can boost this natural process, preserving your skin's health, elasticity, and radiance. By supporting skin cell repair, these ingredients combat premature ageing and help maintain a firm, plump, and toned complexion.

Antioxidant

Antioxidant Protection shields your skin and preserves its youthful glow. It refers to a defence system that protects against harmful molecules and keeps your complexion healthy and radiant. Free radicals, those incredibly reactive molecules, come from everyday sources like sunlight, diet, smoking, and pollution. They attack healthy cells, accelerating skin ageing, causing wrinkles, loss of firmness, pigmentation, and dullness.

Incorporating antioxidants, such as vitamins C and E, into your skincare routine creates a protective shield on your skin. These powerful ingredients neutralise free radicals, preventing them from causing damage. The result is skin that stays youthful, firm, and luminous.

Hydrating

Hydration is all about the water content in your skin that keeps it supple and healthy. Humectants, ingredients with water-binding properties, deliver this hydration by attracting water molecules from the atmosphere. For the best results, apply hydrating serums right after a shower. Humectants not only replenish your skin's hydration but also enhance its water retention, creating a long-lasting hydration reservoir. Adding humectants like hyaluronic acid to your routine will restore your skin's healthy glow, minimize fine lines, and provide a plumping effect.

Anti-Inflammatory

Anti-Inflammatory skincare soothes, heal, and balance your skin, the targeted actives are designed to reduce inflammation. Inflammation is your body's natural response to injury or irritation, but continuous inflammation can lead to troublesome skin conditions like acne, rosacea, or eczema. Our anti-inflammatory skincare solutions work to soothe and calm your skin, reducing redness, swelling, and discomfort to provide much-needed relief. By strengthening your skin's barrier, these products help protect against further irritation and damage. Additionally, the anti-inflammatory actives support your skin's natural healing processes, leading to a more balanced and resilient complexion.

  • - + Anti-Ageing (Epigenetics)
  • - + Anti-Wrinkle
  • - + Firming
  • - + Plumping
  • - + Brightening
  • - + Repairing
  • - + Antioxidant
  • - + Hydrating
  • - + Anti-Inflammatory

Active Ingredients

  • - + Beta-Glucan
  • - + Myorelax Peptide
  • - + Vitamin B3 (Niacinamide)
  • - + Yeast Extract
  • - + Low Molecular Weight Hyaluronic Acid (Sodium Hyaluronate)
  • - + TÈlomeractiv©
  • - + Onion, Myrrh & Myrtle Extract
  • - + Witch Hazel & St John's Wort Extract
  • - + White Tea Leaf Extract
Beta-Glucan

Beta-glucan, derived from yeast, is a chain of sugar molecule known for its humectant (hydrating), collagen-boosting, and anti-inflammatory properties. It strengthens the skin barrier, supports a balanced microbiome, and enhances resilience against environmental aggressors. Beta-glucan deeply hydrates the skin, diminishes wrinkles, and provides a soothing effect, making a great multi-benefit ingredient for all skin types.

Myorelax Peptide

The Myorelax Peptide is a type of a small peptide that effectively relaxes muscle tension and inhibits micro-contractions, offering a gentle and non-invasive alternative anti-wrinkle injectables. This action reduces the depth and length of expression lines and wrinkles, providing a filling and smoothing effect.

Vitamin B3 (Niacinamide)

Vitamin B3 also known as Niacinamide, is versatile and highly effective ingredient with many benefits. It helps to strengthen skin barrier function and increase water retention by increasing natural ceramide production. It's anti-inflammatory and sebum regulating properties soothe, repair and balance irritated, weakened and acne prone skins. Niacinamide is also a potent antioxidant with protective and brightening properties helping to restore skin's natural glow.

Yeast Extract

Yeast extract is a bio-fermented active that helps rebalance the skin’s microbiome while regulating excess sebum and reducing congestion or dullness. By supporting a healthier microbial environment, it limits the growth of unwanted bacteria on the skin’s surface, helping to purify and refine texture without stripping or irritation. Its enzymatic action also encourages gentle cellular turnover, which helps lift away built-up dead skin cells and improves clarity, contributing to a brighter and more even complexion. Furthermore, yeast helps to reinforce barrier function so the skin remains more stable, resilient, and less reactive over time. This makes yeast extract especially effective for skin that is unbalanced, oily-tendency, stressed by urban pollution, or in need of both soothing repair and a clearer, healthier surface environment.

Low Molecular Weight Hyaluronic Acid (Sodium Hyaluronate)

Low Molecular Weight Hyaluronic Acid (LMW-HA) is a smaller, more penetrative form of hyaluronic acid. Unlike high molecular weight forms that primarily hydrate the skin’s surface, LMW-HA has the ability to penetrate deeper into the epidermis, where it attracts and binds water to maintain optimal moisture levels from within. This deep hydration helps improve skin elasticity, firmness, and smoothness, while reducing the appearance of fine lines and dehydration-induced wrinkles. Additionally, LMW-HA supports skin barrier repair and enhances overall suppleness, making the complexion look plumper and more resilient. It is ideal for dehydrated, dull, or mature skin, and especially those in need of long-lasting hydration and improved texture.

TÈlomeractiv©

TÈlomeractiv© is a breakthrough anti-ageing ingredient that protects telomeres, which are the protective caps at the ends of our chromosomes. These caps are crucial for maintaining healthy cell division. Every time cells divide, telomeres get shorter, which leads to cell ageing and eventual senescence (when cells stop dividing and functioning properly). TÈlomeractiv© helps maintain telomere length by providing important amino acids, peptides, and proteins needed for cell repair and activating telomerase, the enzyme that extends telomeres. Its antioxidant properties also reduce free radical damage, a major cause of telomere shortening. By supporting overall cell health, TÈlomeractiv© helps delay the signs of premature skin ageing.

Onion, Myrrh & Myrtle Extract

Unique to Biologique Recherche, the "Complex of Onion, Myrrh & Myrtle" has incredible astringent (tightening), purifying, antioxidant and soothing properties; which is very effective for an oilier complexion combatting sebum-regulation, acne or congestion.

Witch Hazel & St John's Wort Extract

Witch Hazel & St. John’s Wort Extract are rich in tannins and flavonoids, delivering powerful astringent benefits that help tighten tissue, refine pores, and smooth the skin’s surface. They are especially effective for regulating excess sebum while also soothing and calming damaged or irritated skin. While St. John’s Wort naturally contains hypericin, a compound with photosensitising potential, in cosmetic formulations it is carefully refined and used at safe levels, making it suitable for daily use.

White Tea Leaf Extract

Extracted from Camelia Sinensis buds, White Tea Leaf Extract is rich in antioxidants like catechins and polyphenols, protecting the skin from environmental damage and premature cellular ageing. Its anti-inflammatory properties soothe irritation and reduce redness, whilst promoting collagen production for enhanced firmness and elasticity.

  • - + Beta-Glucan
  • - + Myorelax Peptide
  • - + Vitamin B3 (Niacinamide)
  • - + Yeast Extract
  • - + Low Molecular Weight Hyaluronic Acid (Sodium Hyaluronate)
  • - + TÈlomeractiv©
  • - + Onion, Myrrh & Myrtle Extract
  • - + Witch Hazel & St John's Wort Extract
  • - + White Tea Leaf Extract

Spotlight

Epigenetics Science

Epigenetics is an exciting area of science that looks at how our environment—things like UV exposure, pollution, and even our daily lifestyle choices—can influence the way our genes behave, without altering the DNA itself. These external factors can speed up skin ageing, cause pigmentation, and increase sensitivity, as they subtly modify how our skin cells function. Environmental influences don’t just affect the way we feel; they also impact our skin, often resulting in visible signs of ageing, uneven tone, and reduced resilience.

But there’s good news—understanding these changes opens up new possibilities for smarter, more targeted skincare. Epigenetic skincare focuses on ingredients and formulations that help counteract the changes caused by these external factors. By targeting the pathways that influence gene expression, epigenetic skincare works to optimise how your skin cells perform, supporting healthier, more youthful-looking skin. Key ingredients like peptides, antioxidants, and botanical extracts are used to repair damage, boost cell regeneration, and enhance the skin’s natural defences against environmental stressors, helping your skin bounce back stronger and more radiant. Using epigenetic skincare feels like giving your skin the extra support it needs to thrive in today’s world. With regular use, you’ll likely notice improvements in skin texture, tone, and overall resilience. It’s a thoughtful approach that works with your skin, not against it, helping you achieve a radiant, healthy complexion that stands up to everyday challenges.

Epigenetic skincare is more than just a trend—it’s a personalised approach to nurturing your skin at a deeper level. By choosing products that target gene expression, you’re investing in your skin’s long-term health and beauty. Embrace this innovative path to skincare, and enjoy the benefits of smoother, firmer, and more resilient skin that reflects your best, most radiant self.

Clinical Proofs

Clinical Proofs

USAGE TEST:
Test carried out on 20 women, from 49 to 65 years old, presenting crow's feet wrinkles and fine lines, for 2
months with product application in the morning and evening.
Test carried out on 22 women, 45 to 60 years old, subject to skin ageing, for 28 days.
By neutralizing the DPPH free radical, Le Grand Sérum helps fight against oxidative stress by
stimulating the skin's antioxidant defences.
Reduces wrinkle depth by 7.9%
86% of women found that their skin was regenerated
91% of women found that their skin was toned
86% of women found that their skin was firmer
95% of women found that their skin was moisturised
91% of women found that their skin was smoother

* The above information has been supplied to the Embassy of Beauty by the brand manufacturer. Embassy of Beauty takes no responsibility for these claimed studies and or results.

Why I love it

  • "The efficacy of Biologique Recherche relies not only on its science-driven approach to balancing and curing the skin, but on its prescriptive and tailored nature."

    X Natalie K-F

    Founder, Embassy of Beauty

    • Biologique Recherche Le Grand Sérum - tackles all facets of ageing and is the ultimate in illuminating, hydrating and rejuvenating the skin.
    Biologique Recherche

    Le Grand Serum

    £660

    The Biologique Recherche Le Grand Serum is a powerful anti-aging face oil. Its luxurious blend of 27 active ingredients slows cell ageing, protects, firms, and regenerates the skin, restoring radiance for a youthful complexion.

    View product