choose 3 samples when you spend £150

OUTLET | La Grande Crème

Biologique Recherche

OUTLET | La Grande Crème

Biologique Recherche
Benefits
  • Anti-Ageing
  • Firming
  • Plumping
  • Anti-Wrinkle
  • Regenerating
  • Anti-Pigmentation
  • Antioxidant
  • Repairing
  • Supports Microbiome
This product is on sale due to it being short dated 30/07/2025. The Biologique Recherche La Grande Crème is an advanced anti-ageing cream formulated to reverse signs of ageing. It harnesses potent actives to promote cellular regeneration, repair DNA damage, and leave skin brighter, firmer, and protected.
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This product is on sale due to it being short dated 30/07/2025. The Biologique Recherche La Grande Crème is an advanced anti-ageing cream formulated to reverse signs of ageing. It harnesses potent actives to promote cellular regeneration, repair DNA damage, and leave skin brighter, firmer, and protected.
Read less
£836 £929
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Order by 1pm next working day delivery
Complimentary samples when you spend £150

More Info

  • - + Who it is for
  • - + How to Apply
  • - + Smell & Texture
  • - + Ingredients
Who it is for
Green tick
For you if
  • Mature
  • Loss of Firmness
  • Loss of Volume
  • Sun Damaged
  • Pigmented
  • Dull
  • Wrinkles
  • Slow Down Ageing
  • Prefer Light Silky Textures
Red Cross
Not For you if
  • Acne-Prone Skin
  • Prefer Richer Textures
How to Apply
Apply a hazelnut-sized amount of La Grande Crème over the face, neck and décolleté. Massage delicately with fingertips, working with upward and outward strokes until the product is fully absorbed.
Smell & Texture

Smell: It has a clean, and very minimal botanical scent

Texture: A thick, waxy and smooth texture

Ingredients

Water (Aqua), Octyldodecanol, Cetearyl Alcohol, Glyceryl Stearate, Butylene Glycol, Glycerin, Propanediol, Alcohol, Undecane, Butyrospermum Parkii (Shea) Butter, Propylene Glycol, Ceteareth-20, Pentaerythrityl Tetrastearate, Sorbitan Stearate, Cetyl Palmitate, Cocoglycerides, Alpha-Glucan Oligosaccharide, Cera Alba (Beeswax), Lactobacillus/Wasabia Japonica Root Ferment Extract, Lecithin, Camellia Sinensis Leaf Extract, Decarboxy Carnosine HCL, Triethanolamine, Pichia Anomala Extract, Paeonia Albiflora Root Extract, PVP, Mimosa Tenuiflora Bark Extract, Onopordum Acanthium Flower/Leaf/Stem Extract, Polyacrylate Crosspolymer-6, Hydrogenated Lecithin, Carbomer, Sodium Lactate, Tannic Acid, Phenethyl Alcohol, Polysorbate 20, Vitis Vinifera (Grape) Juice Extract, Carum Carvi (Caraway) Fruit Oil, Jasminum Grandiflorum (Flower) Flower Extract, Caprylyl Glycol, Sambucus Nigra Flower Extract, Terminalia Catappa Leaf Extract, Soy Isoflavones, Lepidium Sativum Sprout Extract, Mentha Piperita (Peppermint) Oil, Acetyl Hexapeptide-8, Sorbic Acid, Maltodextrin, Tocopherol, Palmitoyl Oligopeptide, Pentapeptide-48, Palmitoyl Tetrapeptide-7, Helianthus Annuus (Sunflower) Seed Oil, Tridecane, Methylpropanediol, Ethylhexylglycerin, Phenoxyethanol, Polysorbate 80, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylhydroxamic Acid, Disodium EDTA, Limonene.

*This product contains nut-derived ingredients and should be avoided by individuals with nut allergies.

The Benefits

Anti-Ageing (Epigenetics)

The breakthrough in anti-ageing skincare leverages the power of epigenetic factors—molecules that influence gene expression without altering DNA sequences. These molecules act like responsive switches, turning certain genes on or off in response to environmental cues and lifestyle choices, thereby dynamically adapting the skin's behaviour to external factors. Recent innovations in anti-ageing products harness epigenetic science by incorporating active ingredients that target these factors directly. By promoting gene expressions that support collagen synthesis, cellular regeneration, and antioxidant defences, these formulas effectively combat skin ageing. They visibly reduce fine lines, wrinkles, and dark spots while enhancing skin texture, elasticity, and radiance. This advanced approach addresses not only visible signs but also the underlying causes of skin ageing for comprehensive rejuvenation.

Firming

Skin firming focuses on boosting your skin's elasticity and tightness to reduce sagging and wrinkles, leaving your skin looking firmer. This is done by stimulating fibroblasts to produce more elastin, the protein that helps your skin stretch and bounce back. To keep your skin firm longer, antioxidants protect these elastin fibres from free radical damage, which can cause early breakdown. This combined action helps maintain a youthful, resilient complexion.

Plumping

Skin plumping involves using active ingredients to boost the production of key structural components like collagen, the dermal-epidermal junction, and glycosaminoglycans (GAGs), giving your skin more volume and density. Collagen provides structural support and firmness, while the dermal-epidermal junction, a thin connective layer, ensures smooth, wrinkle-free skin by facilitating cell communication. GAGs, like hyaluronic acid, keep your skin hydrated and plump from within. By stimulating these components, active ingredients help restore your skin's plumpness and radiance.

Anti-Wrinkle

Anti-wrinkle products work to smooth out fine lines and wrinkles by boosting collagen and elastin, essential proteins that keep your skin glowing. Collagen helps reduce wrinkle depth, while elastin shortens their length. Keeping your skin hydrated is crucial, as dehydration can make wrinkles more noticeable. For smooth, bouncy skin, ensure you stay well-hydrated and use products that promote collagen and elastin production.

Regenerating

Regenerative benefits work to restore and renew your skin at a cellular level. By stimulating cell turnover and boosting collagen and elastin production, they help repair damage, diminish fine lines and wrinkles, and improve overall skin texture. The result is a rejuvenated, firmer, and more youthful complexion that radiates vitality.

Anti-Pigmentation

Dealing with pigmentation means targeting melanin overproduction to reduce dark spots and prevent new ones. Melanin production can be triggered by UV exposure, pollution, hormonal changes (like during pregnancy), and inflammation (from acne or cuts). This excess pigment is then transferred to surrounding cells in epidermis called keratinocytes, which then moves to the skin's surface, causing visible dark spots.

To treat hyperpigmentation, a personalised and consistent approach is needed. Our anti-pigmentation products include lightening agents to block tyrosinase (the enzyme that creates melanin), antioxidants to fight free radicals, and ingredients to speed up skin cell turnover, removing pigmented cells. Using broad-spectrum sun protection is crucial to prevent new pigmentation during treatment.

Microbiome Balancing

Microbiome Balancing involves maintaining a healthy balance of microorganisms (bacteria, fungi, viruses) that live on your skin. Your skin's microbiome is crucial for protecting against pathogens, regulating pH, maintaining a healthy barrier, and ensuring optimal hydration. A balanced microbiome leads to clearer, healthier skin that’s more resilient to irritation and inflammation. Probiotics, prebiotics, and postbiotics are key ingredients that support a healthy microbiome. Probiotics introduce beneficial bacteria, prebiotics fuel the growth of good bacteria and help balance pH, and postbiotics enhance hydration and strengthen the skin barrier. This combination helps your skin stay healthy and vibrant.

Antioxidant

Antioxidant Protection shields your skin and preserves its youthful glow. It refers to a defence system that protects against harmful molecules and keeps your complexion healthy and radiant. Free radicals, those incredibly reactive molecules, come from everyday sources like sunlight, diet, smoking, and pollution. They attack healthy cells, accelerating skin ageing, causing wrinkles, loss of firmness, pigmentation, and dullness.

Incorporating antioxidants, such as vitamins C and E, into your skincare routine creates a protective shield on your skin. These powerful ingredients neutralise free radicals, preventing them from causing damage. The result is skin that stays youthful, firm, and luminous.

Repairing

Repairing your skin means restoring cells damaged by external factors like UV rays and free radicals, which can harm cell DNA and slow regeneration. Although our cells naturally repair themselves, this ability weakens over time due to ageing and repeated environmental exposure. Active ingredients can boost this natural process, preserving your skin's health, elasticity, and radiance. By supporting skin cell repair, these ingredients combat premature ageing and help maintain a firm, plump, and toned complexion.

  • - + Anti-Ageing (Epigenetics)
  • - + Firming
  • - + Plumping
  • - + Anti-Wrinkle
  • - + Regenerating
  • - + Anti-Pigmentation
  • - + Microbiome Balancing
  • - + Antioxidant
  • - + Repairing

Active Ingredients

Mimosa Tenuiflora Extract

The Mimosa Tenuiflora Extract aids in stimulating tissue repair to regenerate new tissue and its anti-microbial & healing benefits protect and repair the skin.

Centella Asiatica

Centella Asiatica is a powerful antioxidant which has immense anti-inflammatory, soothing and wound-healing benefits. Rich in chlorophyll, it is also extremely proficient at reducing redness. Also known as "Tiger Grass" as tigers were known to roll in it after having been wounded.

Skin-Protective Sugars

Skin-Protective Sugars are obtained through a fermentation process. They support a healthy and balanced skin microbiome, enhancing the skin's defence mechanisms against environmental aggressors and pathogens that can cause skin irritation.

Low Molecular Weight Hyaluronic Acid (Sodium Hyaluronate)

Low Molecular Weight Hyaluronic Acid or Sodium Hyaluronate, is a salt form of naturally occurring hyaluronic acid. Sodium Hyaluronate has a low molecular size (<70 kDa), which allows it to penetrate the skin deeper and more effectively. Sodium Hyaluronate has superior hydrating and skin-plumping benefits. Increased skin hydration also contributes to efficient natural skin exfoliation, supporting the skin's natural renewal cycle.

Grape juice extract enriched with ?-viniferin

?-viniferin is a polyphenol compound found in certain fungi that grow on grapes. It is known for its potent antioxidant properties, similar to resveratrol, another compound found in grapes. Antioxidants like ?-viniferin help protect skin cells from damage caused by free radicals and environmental stressors, thereby preventing premature ageing.

In addition to its antioxidant effects, ?-viniferin also stimulates collagen production in the skin. Collagen is a protein essential for skin structure, helping to maintain firmness, elasticity, and smoothness. By promoting collagen synthesis, ?-viniferin contributes to reducing the appearance of wrinkles and fine lines, while enhancing skin firmness and overall plumpness.

Argireline

Argeriline also known as Acetyl Hexapeptide-8 is a neurotransmitter-inhibiting peptide, meaning it can minimise muscle contractions to provide injection-free wrinkle smoothing results. It can also support collagen in the skin, helping to persevere skin firmness.

EpigenActiv©

EpigenActiv© is an advanced pentapeptide that works by targeting Epidermal Growth Factor (EGF) receptors crucial for skin regeneration and protein recycling. It inhibits microRNAs that impede skin repair processes with age, accelerating cellular renewal and regeneration to promote a youthful appearance. Additionally, EpigenActiv© activates the SKP1 gene, which aids in cellular detoxification, helping eliminate waste. This dual action enhances skin clarity, resilience, and overall health, contributing to a radiant complexion.

Carcinine

Carcinine is a synthetic peptide that has anti-glycation and antioxidant properties. Glycation is a natural process where sugars in the bloodstream bind to proteins, forming harmful molecules called Advanced Glycation End Products (AGEs). These AGEs can contribute to skin ageing by damageing collagen and elastin fibers, leading to wrinkles and loss of elasticity.

Carcinine works by inhibiting the glycation process. It can bind to sugars before they attach to proteins, thereby preventing the formation of AGEs. Additionally, Carcinine has been shown to break down existing AGEs, converting them into harmless byproducts that can be more easily eliminated by the body.

Carcinine is used to help maintain skin's youthful appearance by protecting collagen and elastin from glycation damage and promoting their repair. This can result in smoother, firmer skin with reduced wrinkles and improved elasticity. Its antioxidant properties further contribute to skin health by neutralising free radicals that can accelerate ageing.

White Tea Leaf Extract

Extracted from Camelia Sinensis buds, White Tea Leaf Extract is rich in antioxidants like catechins and polyphenols, protecting the skin from environmental damage and premature cellular ageing. Its anti-inflammatory properties soothe irritation and reduce redness, whilst promoting collagen production for enhanced firmness and elasticity.

Complex of Matrikines

A Complex of Matrikines are peptides already naturally present in the skin; they are cellular messengers which are capable of sequencing events to spark and improve the healing process. As we age, these peptides diminish significantly in their number and their abilities; this Complex not only stimulates the synthesis of these peptides, but it also improves the environment in which they reside, empowering them. Therefore, this Complex protects the skin against photo-ageing and time-ageing as it reverses the chronological ageing process by reducing the depth and surface area of wrinkles, and increases skin firmness and elasticity.

Tree Peony Root Extract

Tree Peony Root Extract is naturally abundant in antioxidants, anti-inflammatory agents, and compounds that brighten and heal, effectively reducing redness, promoting an even complexion, accelerating cell regeneration, and enhancing hydration.

Wasabi Extract

Wasabi has powerful antioxidant and antiseptic properties, helping to protect skin cells from free radical damage and support skin healing.

Complex of Watercress Sprout Extract and Soy-based Pure Genistin

The Complex of Watercress Sprout Extract and Soy-based Pure Genistin targets dark spots by inhibiting melanin and lipofuscin (oxidized sebum) production. It also offers photo-protective properties, preventing premature ageing of skin cells.

  • - + Mimosa Tenuiflora Extract
  • - + Centella Asiatica
  • - + Skin-Protective Sugars
  • - + Low Molecular Weight Hyaluronic Acid (Sodium Hyaluronate)
  • - + Grape juice extract enriched with ?-viniferin
  • - + Argireline
  • - + EpigenActiv©
  • - + Carcinine
  • - + White Tea Leaf Extract
  • - + Complex of Matrikines
  • - + Tree Peony Root Extract
  • - + Wasabi Extract
  • - + Complex of Watercress Sprout Extract and Soy-based Pure Genistin

Spotlight

Epigenetics Science

Epigenetics is an exciting area of science that looks at how our environment—things like UV exposure, pollution, and even our daily lifestyle choices—can influence the way our genes behave, without altering the DNA itself. These external factors can speed up skin ageing, cause pigmentation, and increase sensitivity, as they subtly modify how our skin cells function. Environmental influences don’t just affect the way we feel; they also impact our skin, often resulting in visible signs of ageing, uneven tone, and reduced resilience.

But there’s good news—understanding these changes opens up new possibilities for smarter, more targeted skincare. Epigenetic skincare focuses on ingredients and formulations that help counteract the changes caused by these external factors. By targeting the pathways that influence gene expression, epigenetic skincare works to optimise how your skin cells perform, supporting healthier, more youthful-looking skin. Key ingredients like peptides, antioxidants, and botanical extracts are used to repair damage, boost cell regeneration, and enhance the skin’s natural defences against environmental stressors, helping your skin bounce back stronger and more radiant. Using epigenetic skincare feels like giving your skin the extra support it needs to thrive in today’s world. With regular use, you’ll likely notice improvements in skin texture, tone, and overall resilience. It’s a thoughtful approach that works with your skin, not against it, helping you achieve a radiant, healthy complexion that stands up to everyday challenges.

Epigenetic skincare is more than just a trend—it’s a personalised approach to nurturing your skin at a deeper level. By choosing products that target gene expression, you’re investing in your skin’s long-term health and beauty. Embrace this innovative path to skincare, and enjoy the benefits of smoother, firmer, and more resilient skin that reflects your best, most radiant self.

Why I love it

  • "The efficacy of Biologique Recherche relies not only on its science-driven approach to balancing and curing the skin, but on its prescriptive and tailored nature."

    X Natalie K-F

    Founder, Embassy of Beauty

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    Biologique Recherche Skincare La Grande Crème: most innovative anti-ageing facial cream.
    Biologique Recherche

    OUTLET | La Grande Crème

    £836 £929

    This product is on sale due to it being short dated 30/07/2025

    The first of its kind in the world!        

    DNA research has finally made it possible to turn back the clock on all the ageing effects caused by environmental factors.

    This science-driven cream is the fruit of years of research and development. It rejuvenates cells, improves the skin's elasticity and plumpness, reduces pigmentation and restructures the facial contours like no other.

    La Grande Crème contains the greatest number of concentrated active ingredients ever used in a Biologique Recherche product. Epigenetic research (the study of genes) enabled scientists to identify the properties of EpigenActiv© in an anti-ageing skincare product. This peptide acts on Epidermal Growth Factor (EGF) receptors.

    This pioneering cream, tackles all age-related phenomena and will leave your skin toned, smooth, protected, radiant and even.

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