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Creme PIGM 400

Biologique Recherche
(9)
ANTI-PIGMENTATION
Creme PIGM 400
Biologique Recherche
(9)
Benefits
  • Anti-Pigmentation
  • Brightening
  • Antioxidant

Biologique Recherche Creme PIGM 400 is an anti-pigmentation cream that prevents sun and age spots, reduces existing brown spots and brightens and evens the complexion, restoring radiance to the skin.

Plum Pulp Extract is a lightening agent that works by inhibiting melanogenesis and melanin transfer to surrounding cells, thus preventing pigmentation from occurring while also strengthening the skin barrier.

The Complex of Watercress Sprout Extract and Soy-based Pure Genistin targets pigmentation through a complementary pathway, preventing the transfer of melanin from melanocytes to keratinocytes and offering photo-protective properties.

Wasabi Extract provides brightening and tone-enhancing benefits by supporting improved microcirculation and reducing oxidative stress, working alongside the formula's other actives to deliver a more radiant complexion.

Anti-ROS and Anti-RNS Antioxidant and Oligosaccharides from Wheat Bran prevent melanogenesis and inhibit tyrosinase activity, collectively producing a measurably more even, brighter and more uniform complexion with consistent use.

Read more

Biologique Recherche Creme PIGM 400 is an anti-pigmentation cream that prevents sun and age spots, reduces existing brown spots and brightens and evens the complexion, restoring radiance to the skin.

Plum Pulp Extract is a lightening agent that works by inhibiting melanogenesis and melanin transfer to surrounding cells, thus preventing pigmentation from occurring while also strengthening the skin barrier.

The Complex of Watercress Sprout Extract and Soy-based Pure Genistin targets pigmentation through a complementary pathway, preventing the transfer of melanin from melanocytes to keratinocytes and offering photo-protective properties.

Wasabi Extract provides brightening and tone-enhancing benefits by supporting improved microcirculation and reducing oxidative stress, working alongside the formula's other actives to deliver a more radiant complexion.

Anti-ROS and Anti-RNS Antioxidant and Oligosaccharides from Wheat Bran prevent melanogenesis and inhibit tyrosinase activity, collectively producing a measurably more even, brighter and more uniform complexion with consistent use.

Read less

50 ml

£302
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Get The Set
Biologique Recherche Intensive Pigmentation Correction Collection
Intensive Pigmentation Correction Collection

Serum PIGM 400
Creme PIGM 400

£589 £559

More Info

  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
Who it is for
Green tick
For you if

Pigmented Skin

Dull Skin

Red Cross
Not For you if

Sensitive Skin

Reactive Skin

Rosacea


Not sure? Consult an expert.

How to Apply
Apply your Crème PIGM 400 to your entire face, neck and décolleté or to specific pigmentation areas avoiding the eye area.
Ingredients

Scroll down the page for a full breakdown of the active ingredients.

Water (Aqua), Coco-Caprylate/Caprate, Pentylene Glycol, Sodium Acrylates Copolymer, Butylene Glycol, Lactobacillus/Wasabia Japonica Root Ferment Extract, Lecithin, Mica, Hydrolyzed Wheat Flour, Castanea Sativa (Chestnut) Seed Extract, Hydrolyzed Prunus Domestica, Helianthus Annuus (Sunflower) Seed Oil, Soy Isoflavones, Lepidium Sativum Sprout Extract, Biosaccharide Gum-4, Dimethylmethoxy Chromanol, Lactic Acid, Sodium Lactate, Proline, Hyaluronic Acid, Silanetriol, Citric Acid, Allantoin, Serine, Glycerin, Tocopherol, Sorbitol, 1,2-Hexanediol, Sodium Stearoyl Glutamate, Titanium Dioxide, Polyglyceryl-6 Caprylate, Alcohol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tea-Lactate, Urea, Methylpropanediol, Caprylyl Glycol, Sodium Benzoate.

Contraindications: This product contains some photo-sensitising ingredients. We recommend applying SPF during the day and only applying it in the evening.


Please note: The ingredients listed in this product are subject to change as the formulation is updated. We aim to update the INCI list as soon as possible, but we encourage you to read the ingredient list on the product itself to ensure it's suitable for your personal use.

Smell & Texture

Smell: It has a clean, subtle, slightly botanical scent

Texture: A medium-thick, creamy and smooth texture

About the Brand
Brand logo
Founded in Paris in the late 1970s by biologist Yvan Allouche and physiotherapist Josette Allouche, Biologique Recherche began as a laboratory for bespoke, high-performance formulas for elite skin professionals. Their medical-grade precision and artisanal formulation, paired with consummate savoir-faire, underpin their reputation for outstanding, clinically proven results.

Biologique Recherche treats skin according to its Skin Instant©, the skin’s precise, evolving state. Each formula is loaded with active ingredients in exceptional concentrations, then prescribed to address those real-time needs. This precision approach corrects imbalances, restores function, and delivers visible, lasting transformation.

Cold-processed actives are the core of Biologique Recherche. Formulated at 18–25°C, this method avoids the 70°C heat of standard processing that breaks down actives. Botanical, marine, and biotechnological extracts stay intact for higher absorption, stronger repair, and better tolerance. Antioxidants, peptides, and enzymes remain stable, ensuring consistent, visible results.

The Benefits

  • - + Anti-Pigmentation
  • - + Brightening (Energising)
  • - + Antioxidant
Anti-Pigmentation

Dealing with pigmentation means targeting melanin overproduction to reduce dark spots and prevent new ones. Melanin production can be triggered by UV exposure, pollution, hormonal changes (like during pregnancy), and inflammation (from acne or cuts). This excess pigment is then transferred to surrounding cells in epidermis called keratinocytes, which then moves to the skin's surface, causing visible dark spots.

To treat hyperpigmentation, a personalised and consistent approach is needed. Our anti-pigmentation products include lightening agents to block tyrosinase (the enzyme that creates melanin), antioxidants to fight free radicals, and ingredients to speed up skin cell turnover, removing pigmented cells. Using broad-spectrum sun protection is crucial to prevent new pigmentation during treatment.

Brightening (Energising)

Brightening skincare involves using active ingredients to boost your blood circulation, detoxification and cellular energy. Improved blood circulation brings more essential nutrients and oxygen to your skin, while detoxification helps eliminate cell waste and impurities that can make your skin look dull. Certain active ingredients also enhance your skin's metabolism and regeneration. These combined actions restore your skin's vitality and radiant appearance, giving you a fresh, energised complexion.

Antioxidant

Antioxidant skincare is dedicated to protecting the skin against oxidative stress—one of the primary drivers of premature ageing and cellular damage—while preserving overall skin integrity and vitality. These formulations rely on potent molecules such as vitamin C, vitamin E, and polyphenols, which neutralize free radicals generated by UV exposure and environmental aggressors before they can compromise cellular structures like lipids, proteins, and DNA. Beyond defence, many antioxidants also support repair processes and enhance collagen stability, contributing to improved firmness, brightness and resilience. The result is skin that is not only shielded from ongoing damage but maintained in a healthier, more luminous state over time.

  • - + Anti-Pigmentation
  • - + Brightening (Energising)
  • - + Antioxidant

Active Ingredients

  • - + Plum Pulp Extract
  • - + Complex of Watercress Sprout Extract and Soy-based Pure Genistin
  • - + Wasabi Extract
  • - + Anti-ROS and anti-RNS Antioxidant
  • - + Oligosaccharides from Wheat Bran
Plum Pulp Extract

Plum Pulp Extract is a lightening agent working on inhibiting melanogenesis (melanin overproduction) and melanin transfer to surrounding cells; thus inhibiting pigmentation from occurring. It also helps to strengthen the skin barrier and reduce Trans epidermal Water Loss (TEWL).

Complex of Watercress Sprout Extract and Soy-based Pure Genistin

The Complex of Watercress Sprout Extract and Soy-based Pure Genistin targets dark spots by inhibiting melanin and lipofuscin (oxidized sebum) production. It also offers photo-protective properties, preventing premature ageing of skin cells.

Wasabi Extract

Wasabi in skincare is valued for its brightening and tone-enhancing properties, helping to revitalise dull, uneven skin. Rich in bioactive compounds such as isothiocyanates, it supports improved microcirculation and helps reduce oxidative stress, both of which contribute to a more radiant complexion. By energising the skin and enhancing its natural glow, wasabi helps promote a brighter, fresher, and more luminous appearance with improved overall clarity.

Anti-ROS and anti-RNS Antioxidant

This targeted antioxidant neutralises Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS), which are common free radicals induced by the environment. By doing so, it prevents melanin overproduction and the formation of lipofuscin, a pigment that results from oxidised sebum (oil); thus reducing the amount of pigment produced. Additionally, it detoxifies the skin and slows down cell ageing, allowing your skin to be more rejuvenated.

Oligosaccharides from Wheat Bran

Oligosaccharides from wheat bran are compounds that effectively reduce pigmentation by preventing the start of melanogenesis, the process that forms dark pigment. They also inhibit tyrosinase activity, an enzyme crucial for melanin production. As a result, they brighten and even out the skin tone, helping to achieve a more uniform complexion.

  • - + Plum Pulp Extract
  • - + Complex of Watercress Sprout Extract and Soy-based Pure Genistin
  • - + Wasabi Extract
  • - + Anti-ROS and anti-RNS Antioxidant
  • - + Oligosaccharides from Wheat Bran
Age & UV Induced Pigmentation

Age and sun pigmentation, often known as hyperpigmentation or sunspots, is a common skin concern where excess melanin causes darkened patches. This can happen due to prolonged sun exposure and the natural ageing process, making our skin look older and less vibrant than we’d like.

Hyperpigmentation typically appears on areas most exposed to the sun, like the face, hands, and shoulders. Over time, UV radiation damages skin cells, leading to uneven skin tone and those familiar sunspots that can leave us feeling a little less confident in our complexion.

When the skin is exposed to UV radiation, it produces melanin as a defence mechanism. However, prolonged exposure and the effects of ageing can lead to an overproduction of melanin, resulting in dark spots and uneven skin tone. The good news is that consistent use of sun protection, antioxidants, and targeted treatments like retinoids or exfoliants can help.

These products work to reduce pigmentation, brighten the skin, and protect against further damage, helping to restore a more even and youthful appearance. With the right care, you can visibly reduce the appearance of age and sun pigmentation.

Regular use of targeted treatments helps brighten your complexion, improve skin tone, and give your skin a renewed radiance. It’s all about finding those little moments in your routine that not only protect but also restore your skin’s natural glow. Addressing pigmentation is a journey, but with patience and the right products, you can bring out the best in your skin.

By incorporating sunscreen, antioxidants, and gentle exfoliants into your daily routine, you’ll be protecting your skin from further damage while gradually reducing the appearance of existing spots. Embrace the process, and enjoy watching your skin transform into a brighter, more even version of itself, glowing with renewed confidence.

Clinical Proofs

EFFICACY TEST:
Instrumental test to assess complexion brightening, pigment spot size and uniformity using the C-Cube 2
dermoscope. Carried out after application of PIGM400 Cream for 56 days, on a panel of 22 women aged 42 to 68
with dull complexions and pigmentation spots.
- Level of melanin
Test results show that Crème PIGM 400’s has depigmenting activity. 9% reduction in skin
pigmentation.
- Skin radiance
L-parameter measurement
Significant increase of 22% on the pigmented area and of 15% on the normal skin area. This increase
in the L parameter translates into increased luminosity and brightening of the skin

Use test
Test carried out over 56 days on 22 women aged 41 to 68, with pigmentation spots and dull complexion

- 91% of participants find their skin less dull
- 87% of participants find their skin nourished
- 87% of participants find their complexion brighter
- 86% of participants find skin hydrated
- 82% of participants find skin supple
- 82% of participants find complexion transparency is preserved
- 78% of participants find their complexion clearer
- 77% of participants find skin comfortable
- 77% of participants find their complexion more even
- 73% of participants find skin more even
- 73% of participants find skin luminosity restored
- 73% of participants find their skin’s overall appearance improved
- 64% of participants found that the product prevented the appearance of pigmentation spots

* The above information has been supplied to the Embassy of Beauty by the brand manufacturer. Embassy of Beauty takes no responsibility for these claimed studies and or results.

Spotlight

Age & UV Induced Pigmentation

Age and sun pigmentation, often known as hyperpigmentation or sunspots, is a common skin concern where excess melanin causes darkened patches. This can happen due to prolonged sun exposure and the natural ageing process, making our skin look older and less vibrant than we’d like.

Hyperpigmentation typically appears on areas most exposed to the sun, like the face, hands, and shoulders. Over time, UV radiation damages skin cells, leading to uneven skin tone and those familiar sunspots that can leave us feeling a little less confident in our complexion.

When the skin is exposed to UV radiation, it produces melanin as a defence mechanism. However, prolonged exposure and the effects of ageing can lead to an overproduction of melanin, resulting in dark spots and uneven skin tone. The good news is that consistent use of sun protection, antioxidants, and targeted treatments like retinoids or exfoliants can help.

These products work to reduce pigmentation, brighten the skin, and protect against further damage, helping to restore a more even and youthful appearance. With the right care, you can visibly reduce the appearance of age and sun pigmentation.

Regular use of targeted treatments helps brighten your complexion, improve skin tone, and give your skin a renewed radiance. It’s all about finding those little moments in your routine that not only protect but also restore your skin’s natural glow. Addressing pigmentation is a journey, but with patience and the right products, you can bring out the best in your skin.

By incorporating sunscreen, antioxidants, and gentle exfoliants into your daily routine, you’ll be protecting your skin from further damage while gradually reducing the appearance of existing spots. Embrace the process, and enjoy watching your skin transform into a brighter, more even version of itself, glowing with renewed confidence.

Clinical Proofs

Clinical Proofs

EFFICACY TEST:
Instrumental test to assess complexion brightening, pigment spot size and uniformity using the C-Cube 2
dermoscope. Carried out after application of PIGM400 Cream for 56 days, on a panel of 22 women aged 42 to 68
with dull complexions and pigmentation spots.
- Level of melanin
Test results show that Crème PIGM 400’s has depigmenting activity. 9% reduction in skin
pigmentation.
- Skin radiance
L-parameter measurement
Significant increase of 22% on the pigmented area and of 15% on the normal skin area. This increase
in the L parameter translates into increased luminosity and brightening of the skin

Use test
Test carried out over 56 days on 22 women aged 41 to 68, with pigmentation spots and dull complexion

- 91% of participants find their skin less dull
- 87% of participants find their skin nourished
- 87% of participants find their complexion brighter
- 86% of participants find skin hydrated
- 82% of participants find skin supple
- 82% of participants find complexion transparency is preserved
- 78% of participants find their complexion clearer
- 77% of participants find skin comfortable
- 77% of participants find their complexion more even
- 73% of participants find skin more even
- 73% of participants find skin luminosity restored
- 73% of participants find their skin’s overall appearance improved
- 64% of participants found that the product prevented the appearance of pigmentation spots

* The above information has been supplied to the Embassy of Beauty by the brand manufacturer. Embassy of Beauty takes no responsibility for these claimed studies and or results.

Why I love it

  • "The efficacy of Biologique Recherche relies not only on its science-driven approach to balancing and curing the skin, but on its prescriptive and tailored nature."

    X Natalie K-F

    Founder, Embassy of Beauty

    • Biologique Recherche Creme PIGM 400 50ml
    Biologique Recherche

    Creme PIGM 400

    £302

    Biologique Recherche Creme PIGM 400 is an anti-pigmentation cream that prevents sun and age spots, reduces existing brown spots and brightens and evens the complexion, restoring radiance to the skin.

    Plum Pulp Extract is a lightening agent that works by inhibiting melanogenesis and melanin transfer to surrounding cells, thus preventing pigmentation from occurring while also strengthening the skin barrier.

    The Complex of Watercress Sprout Extract and Soy-based Pure Genistin targets pigmentation through a complementary pathway, preventing the transfer of melanin from melanocytes to keratinocytes and offering photo-protective properties.

    Wasabi Extract provides brightening and tone-enhancing benefits by supporting improved microcirculation and reducing oxidative stress, working alongside the formula's other actives to deliver a more radiant complexion.

    Anti-ROS and Anti-RNS Antioxidant and Oligosaccharides from Wheat Bran prevent melanogenesis and inhibit tyrosinase activity, collectively producing a measurably more even, brighter and more uniform complexion with consistent use.

    View product