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Creme Biofixine

(8)
TIGHTEN & REWIND
Creme Biofixine
Biologique Recherche
(8)
Benefits
  • Anti-Wrinkle
  • Firming
  • Lifting
  • Plumping
  • Regenerating
  • Anti-Pigmentation
  • Scar-Repairing
  • Brightening
  • Anti-Inflammatory
  • Anti-Redness
  • Antioxidant

Biologique Recherche Creme Biofixine minimises micro-contractions to prevent deep wrinkles and fine lines. Enriched with antioxidants, it combats premature skin ageing while brightening and protecting the skin.

The Myorelax Peptide — a small peptide that effectively relaxes muscle tension and inhibits micro-contractions — offers a gentle, non-invasive alternative to anti-wrinkle injectables, progressively reducing the depth and length of expression lines and providing a smoothing and filling effect.

Edelweiss Extract is rich in flavonoids, delivering remarkable antioxidant and anti-inflammatory properties to protect cells from external attack and premature ageing.

The Biologique Recherche Oxygenating Complex — combining melatonin, yeast extract and Lactobacillus ferment — enhances the skin's ability to use oxygen efficiently at a cellular level, while Walnut Extract provides additional toning and astringent benefits that reinforce the skin's natural firmness.

Used consistently, this cream produces a measurably smoother, firmer and more relaxed-looking complexion, with noticeably reduced expression lines and improved overall skin density.

Read more

Biologique Recherche Creme Biofixine minimises micro-contractions to prevent deep wrinkles and fine lines. Enriched with antioxidants, it combats premature skin ageing while brightening and protecting the skin.

The Myorelax Peptide — a small peptide that effectively relaxes muscle tension and inhibits micro-contractions — offers a gentle, non-invasive alternative to anti-wrinkle injectables, progressively reducing the depth and length of expression lines and providing a smoothing and filling effect.

Edelweiss Extract is rich in flavonoids, delivering remarkable antioxidant and anti-inflammatory properties to protect cells from external attack and premature ageing.

The Biologique Recherche Oxygenating Complex — combining melatonin, yeast extract and Lactobacillus ferment — enhances the skin's ability to use oxygen efficiently at a cellular level, while Walnut Extract provides additional toning and astringent benefits that reinforce the skin's natural firmness.

Used consistently, this cream produces a measurably smoother, firmer and more relaxed-looking complexion, with noticeably reduced expression lines and improved overall skin density.

Read less

50 ml

£323
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Get The Set
Biologique Recherche Fine Line & Volume Restore Collection
Fine Line & Volume Restore Collection

Creme PTO Metamorphique
Creme Biofixine

£555 £527

More Info

  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
Who it is for
Green tick
For you if

Dull Skin

Wrinkles

Red Cross
Not For you if
How to Apply
Apply a hazelnut-sized amount of Crème Biofixine over the face, neck and décolleté. Massage delicately with fingertips, working with upward and outward strokes until the product is fully absorbed.
Ingredients

Scroll down the page for a full breakdown of the active ingredients.

Water (Aqua), Stearic Acid, Glycerin, Propylene Glycol, Palmitic Acid, Vitis Vinifera (Grape) Seed Oil, Cetyl Alcohol, Pentylene Glycol, Polysorbate 40, Helianthus Annuus (Sunflower) Seed Oil, Butylene Glycol, PEG-2 Stearate, Tea-Steareth, Juglans Regia (Walnut) Seed Extract, Leontopodium Alpinum Flower/Leaf Extract, Nasturtium Officinale Extract, Pimpinella Anisum (Anise) Fruit Extract, Acetyl Hexapeptide-8, Perfluorodecalin, Polyperfluoromethylisopropyl Ether, Poloxamer 188, Caprylyl Glycol, P-Anisic Acid, Phenoxyethanol, Benzoic Acid, Sodium Benzoate, Sodium Metabisulfite, Sorbic Acid.

* This product contains nut-derived ingredients and should be avoided by individuals with nut allergies.


Please note: The ingredients listed in this product are subject to change as the formulation is updated. We aim to update the INCI list as soon as possible, but we encourage you to read the ingredient list on the product itself to ensure it's suitable for your personal use.

Smell & Texture

Smell: It has a clean, subtle, slightly botanical scent

Texture: A thick, creamy and smooth texture

About the Brand
Brand logo
Founded in Paris in the late 1970s by biologist Yvan Allouche and physiotherapist Josette Allouche, Biologique Recherche began as a laboratory for bespoke, high-performance formulas for elite skin professionals. Their medical-grade precision and artisanal formulation, paired with consummate savoir-faire, underpin their reputation for outstanding, clinically proven results.

Biologique Recherche treats skin according to its Skin Instant©, the skin’s precise, evolving state. Each formula is loaded with active ingredients in exceptional concentrations, then prescribed to address those real-time needs. This precision approach corrects imbalances, restores function, and delivers visible, lasting transformation.

Cold-processed actives are the core of Biologique Recherche. Formulated at 18–25°C, this method avoids the 70°C heat of standard processing that breaks down actives. Botanical, marine, and biotechnological extracts stay intact for higher absorption, stronger repair, and better tolerance. Antioxidants, peptides, and enzymes remain stable, ensuring consistent, visible results.

The Benefits

  • - + Anti-Wrinkle
  • - + Firming & Lifting
  • - + Plumping
  • - + Micro-Needling Effect
  • - + Anti-Pigmentation
  • - + Scar-Repairing
  • - + Brightening (Energising)
  • - + Injectable Effect
  • - + Brightening (Oxygenation)
  • - + Anti-Inflammatory
  • - + Anti-Redness
  • - + Antioxidant
Anti-Wrinkle

Anti-wrinkle skincare is focused on both preventing and visibly reducing the formation of lines by targeting the structural and dynamic causes of wrinkles within the skin. Fine lines and deeper wrinkles develop as collagen and elastin decline, cell turnover slows and repeated facial movements create creases that become etched over time. Advanced formulations address these mechanisms through a combination of elastin-stimulating actives, smoothing peptides that help relax the appearance of expression lines, and deeply hydrating ingredients that plump the skin from within. By reinforcing the skin’s architecture while softening surface contractions and improving elasticity, anti-wrinkle skincare delivers a visibly smoother complexion.

Firming & Lifting

Firming & Lifting skincare is designed to restore strength, structure, and definition to the skin, creating a visibly tighter, more sculpted appearance. As the skin loses collagen and elasticity over time, it can begin to soften and sag, losing its natural contours. Advanced formulations work to rebuild this support from within—boosting firmness while helping to visibly lift and redefine the skin. The result is a smoother, more toned complexion with enhanced bounce and resilience, where facial contours appear sharper and elevated.

Plumping

Plumping involves using active ingredients to boost the production of key structural components like collagen, the dermal-epidermal junction and glycosaminoglycans (GAGs), giving your skin more volume and density. Collagen provides structural support and firmness, while the dermal-epidermal junction, a thin connective layer, ensures smooth, wrinkle-free skin by facilitating cell communication. GAGs, like hyaluronic acid, keep your skin hydrated and plump from within. By stimulating these components, active ingredients help restore your skin's plumpness and radiance.

Micro-Needling Effect

Micro-needling effect skincare is designed to stimulate the regeneration of new, healthy skin by activating the skin’s natural repair mechanisms—without the need for needles. Through controlled micro-stimulation, these formulations encourage accelerated cell turnover and boost collagen and elastin production, resulting in firmer, smoother, and more youthful-looking skin. This regenerative process not only softens fine lines and improves skin density, but also helps reduce the appearance of pigmentation and scarring by promoting the renewal of more even, uniform skin. By continuously supporting the formation of fresh skin cells, this approach refines texture, enhances clarity, and reveals a complexion that appears more resilient, radiant, and visibly rejuvenated over time.

Anti-Pigmentation

Dealing with pigmentation means targeting melanin overproduction to reduce dark spots and prevent new ones. Melanin production can be triggered by UV exposure, pollution, hormonal changes (like during pregnancy), and inflammation (from acne or cuts). This excess pigment is then transferred to surrounding cells in epidermis called keratinocytes, which then moves to the skin's surface, causing visible dark spots.

To treat hyperpigmentation, a personalised and consistent approach is needed. Our anti-pigmentation products include lightening agents to block tyrosinase (the enzyme that creates melanin), antioxidants to fight free radicals, and ingredients to speed up skin cell turnover, removing pigmented cells. Using broad-spectrum sun protection is crucial to prevent new pigmentation during treatment.

Scar-Repairing

Anti-Scarring skincare targets the textured scars left by acne breakouts. These scars form due to inflammation disrupting collagen and elastin fibres leading to uneven healing and indented areas. Anti-Scarring actives harness growth factors and exfoliating actives to stimulate cell repair and regeneration, optimising the skin's healing process to reduce scar formation. They also effectively diminish older scars, improving overall skin texture and leaving you with a smoother complexion and significantly reduced scar visibility.

Brightening (Energising)

Brightening skincare involves using active ingredients to boost your blood circulation, detoxification and cellular energy. Improved blood circulation brings more essential nutrients and oxygen to your skin, while detoxification helps eliminate cell waste and impurities that can make your skin look dull. Certain active ingredients also enhance your skin's metabolism and regeneration. These combined actions restore your skin's vitality and radiant appearance, giving you a fresh, energised complexion.

Injectable Effect

The ''Injectable-Like Effect'' involves using these neurotransmitter-inhibiting peptides to relax tiny facial muscles, smoothing out existing wrinkles. This process also stimulates the natural production of collagen and elastin, helping to prevent new wrinkles from forming.

Brightening (Oxygenation)

Brightening your skin means restoring its natural glow. One way to do this is through oxygenation, which helps skin cells "breathe" better by delivering more oxygen. Perfluorocarbons are key ingredients that carry oxygen into the skin cells. This process also boosts blood circulation and removes skin cell waste, resulting in brighter, more radiant skin.

Anti-Inflammatory

Anti-Inflammatory skincare soothes, heal, and balance your skin, the targeted actives are designed to reduce inflammation. Inflammation is your body's natural response to injury or irritation, but continuous inflammation can lead to troublesome skin conditions like acne, rosacea, or eczema. Our anti-inflammatory skincare solutions work to soothe and calm your skin, reducing redness, swelling, and discomfort to provide much-needed relief. By strengthening your skin's barrier, these products help protect against further irritation and damage. Additionally, the anti-inflammatory actives support your skin's natural healing processes, leading to a more balanced and resilient complexion.

Anti-Redness

Anti-Redness skincare is all about reducing and preventing facial or body redness, which can result from irritation, skin conditions, compromised barriers, and hormonal changes. A targeted approach with multiple strategies works best for tackling redness. Anti-Redness formulations include active ingredients that soothe and strengthen your skin barrier. Their anti-inflammatory and antioxidant properties calm inflammation and protect against environmental irritants. Additionally, these ingredients have vasoconstrictive properties, meaning they reduce blood vessel dilation to lessen redness. Together, these actions help achieve a more even-toned, balanced complexion that's less prone to redness flare-ups.

Antioxidant

Antioxidant skincare is dedicated to protecting the skin against oxidative stress—one of the primary drivers of premature ageing and cellular damage—while preserving overall skin integrity and vitality. These formulations rely on potent molecules such as vitamin C, vitamin E, and polyphenols, which neutralize free radicals generated by UV exposure and environmental aggressors before they can compromise cellular structures like lipids, proteins, and DNA. Beyond defence, many antioxidants also support repair processes and enhance collagen stability, contributing to improved firmness, brightness and resilience. The result is skin that is not only shielded from ongoing damage but maintained in a healthier, more luminous state over time.

  • - + Anti-Wrinkle
  • - + Firming & Lifting
  • - + Plumping
  • - + Micro-Needling Effect
  • - + Anti-Pigmentation
  • - + Scar-Repairing
  • - + Brightening (Energising)
  • - + Injectable Effect
  • - + Brightening (Oxygenation)
  • - + Anti-Inflammatory
  • - + Anti-Redness
  • - + Antioxidant

Active Ingredients

  • - + Walnut Extract
  • - + Myorelax Peptide
  • - + Biologique Recherche Oxygenating Complex
  • - + Eldeweiss Extract
  • - + Stearic Acid
Walnut Extract

Walnut Extract counteracts skin ageing by stimulating fibroblast activity and inhibiting elastase. Meaning that it prevents the natural elastin in our skin from degrading, promoting a more elastic and smoother skin, whilst reducing fine lines & wrinkles and promoting a more toned skin. This ingredient also has powerful antioxidant properties which prevents cells from oxidative stress.

Myorelax Peptide

The Myorelax Peptide is a type of a small peptide that effectively relaxes muscle tension and inhibits micro-contractions, offering a gentle and non-invasive alternative anti-wrinkle injectables. This action reduces the depth and length of expression lines and wrinkles, providing a filling and smoothing effect.

Biologique Recherche Oxygenating Complex

Biologique Recherche's "Oxygenating Complex" utilises Perfluorodecalin to enhance cellular respiration by delivering oxygen deep into the skin. This ingredient effectively carries oxygen to the skin's deepest layers, promoting rejuvenation, plumping, reducing wrinkles, and brightening the complexion.

Eldeweiss Extract

Edelweiss is rich in Flavonoids, it boast remarkable antioxidant and anti-inflammatory properties which helps to protect cells from external attack and premature ageing. Its soothing benefits are highly beneficial for dry and sensitive skins.

Stearic Acid

Stearic Acid is a naturally occurring fatty acid that functions as an emollient and texture enhancer in skincare formulations. It helps to soften and smooth the skin while reinforcing the lipid barrier, reducing moisture loss and improving overall comfort. Commonly used to stabilise creams and lotions, it contributes to a rich, velvety texture that supports hydration and leaves the skin feeling nourished and supple.

  • - + Walnut Extract
  • - + Myorelax Peptide
  • - + Biologique Recherche Oxygenating Complex
  • - + Eldeweiss Extract
  • - + Stearic Acid
Myorelax Peptide

Myorelax Peptide is a hexapeptide-based anti-wrinkle agent designed to gently relax facial muscles and reduce expression lines. It minimises muscle tension responsible for wrinkle formation, leading to smoother, fresher-looking skin. It works similarly to Botox (Botulinum toxin) by reducing muscle micro-tension but offers a gentler, non-invasive alternative. The peptide is a safe, effective option for those seeking a more natural approach to wrinkle correction, leaving skin visibly smoother and rejuvenated over time.

Clinical Proofs

EFFICACY TEST:
- Anti-wrinkle effect
There was a statistically significant reduction in the parameters that characterise the skin surface
with tighter skin observed in participants.
- Decrease in average roughness: -4%
- Decrease in the maximum roughness range: -5%
16
*Test conducted on 22 women aged 45 to 65 with wrinkles and fine lines in the outer eye area. Optical 3D
measurements were taken at the beginning of the study and after applying the product once.

USAGE TEST:
*Test conducted on 20 volunteers aged 41 to 64 with wrinkles and fine lines, applying the product 3 times a week
for 28 days.

- 91% of participants said their expression lines were corrected
- 95% of participants said their dehydration lines were less visible
- 82% of participants said their wrinkles and fine lines were reduced
- 87% of participants said the length of their wrinkles was reduced
- 91% of participants said the depth of their wrinkles was reduced
- 96% of participants said their wrinkles and fine lines were plumped up
- 100% of participants said their skin was smoother
- 87% of participants said their facial features were tightened

* The above information has been supplied to the Embassy of Beauty by the brand manufacturer. Embassy of Beauty takes no responsibility for these claimed studies and or results.

Spotlight

Myorelax Peptide

Myorelax Peptide is a hexapeptide-based anti-wrinkle agent designed to gently relax facial muscles and reduce expression lines. It minimises muscle tension responsible for wrinkle formation, leading to smoother, fresher-looking skin. It works similarly to Botox (Botulinum toxin) by reducing muscle micro-tension but offers a gentler, non-invasive alternative. The peptide is a safe, effective option for those seeking a more natural approach to wrinkle correction, leaving skin visibly smoother and rejuvenated over time.

Clinical Proofs

Clinical Proofs

EFFICACY TEST:
- Anti-wrinkle effect
There was a statistically significant reduction in the parameters that characterise the skin surface
with tighter skin observed in participants.
- Decrease in average roughness: -4%
- Decrease in the maximum roughness range: -5%
16
*Test conducted on 22 women aged 45 to 65 with wrinkles and fine lines in the outer eye area. Optical 3D
measurements were taken at the beginning of the study and after applying the product once.

USAGE TEST:
*Test conducted on 20 volunteers aged 41 to 64 with wrinkles and fine lines, applying the product 3 times a week
for 28 days.

- 91% of participants said their expression lines were corrected
- 95% of participants said their dehydration lines were less visible
- 82% of participants said their wrinkles and fine lines were reduced
- 87% of participants said the length of their wrinkles was reduced
- 91% of participants said the depth of their wrinkles was reduced
- 96% of participants said their wrinkles and fine lines were plumped up
- 100% of participants said their skin was smoother
- 87% of participants said their facial features were tightened

* The above information has been supplied to the Embassy of Beauty by the brand manufacturer. Embassy of Beauty takes no responsibility for these claimed studies and or results.

Why I love it

  • "The efficacy of Biologique Recherche relies not only on its science-driven approach to balancing and curing the skin, but on its prescriptive and tailored nature."

    X Natalie K-F

    Founder, Embassy of Beauty

  • Biologique Recherche Creme Biofixine 50ml
    Biologique Recherche

    Creme Biofixine

    £323

    Biologique Recherche Creme Biofixine minimises micro-contractions to prevent deep wrinkles and fine lines. Enriched with antioxidants, it combats premature skin ageing while brightening and protecting the skin.

    The Myorelax Peptide — a small peptide that effectively relaxes muscle tension and inhibits micro-contractions — offers a gentle, non-invasive alternative to anti-wrinkle injectables, progressively reducing the depth and length of expression lines and providing a smoothing and filling effect.

    Edelweiss Extract is rich in flavonoids, delivering remarkable antioxidant and anti-inflammatory properties to protect cells from external attack and premature ageing.

    The Biologique Recherche Oxygenating Complex — combining melatonin, yeast extract and Lactobacillus ferment — enhances the skin's ability to use oxygen efficiently at a cellular level, while Walnut Extract provides additional toning and astringent benefits that reinforce the skin's natural firmness.

    Used consistently, this cream produces a measurably smoother, firmer and more relaxed-looking complexion, with noticeably reduced expression lines and improved overall skin density.

    View product