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Serum PIGM 400

(2)
ILLUMINATING ELIXIR
Serum PIGM 400
Biologique Recherche
(2)
Benefits
  • Anti-Pigmentation
  • Antioxidant
  • Barrier-Strengthening
  • Anti-Wrinkle
  • Firming
  • Lifting
  • Plumping
  • Regenerating
  • Scar-Repairing
  • Brightening

Serum PIGM 400 by Biologique Recherche is a targeted anti-pigmentation serum formulated to prevent new dark spots from forming, reduce the appearance of existing hyperpigmentation and leave the complexion more even, unified and luminous.

A complex of Watercress Sprout Extract and Soy-based Pure Genistein provides the formula's core brightening action, while a Chromanyl Palmitate-based Synthetic Peptide — a stabilised Vitamin E derivative — adds a further layer of antioxidant protection. Plum Pulp Extract rounds out the active brightening complex, working at the skin's surface to visibly fade existing discolouration through natural acids and brightening compounds.

The watercress targets oxidative stress triggers at their source by neutralising both reactive oxygen species (ROS) and reactive nitrogen species (RNS), while Pure Genistein acts directly on the melanogenesis pathway to inhibit pigment synthesis at the cellular level. The Chromanyl Peptide intercepts free radical chains before they can stimulate melanocyte activity, helping to prevent the environmental triggers that cause dark spots to recur.

Read more

Serum PIGM 400 by Biologique Recherche is a targeted anti-pigmentation serum formulated to prevent new dark spots from forming, reduce the appearance of existing hyperpigmentation and leave the complexion more even, unified and luminous.

A complex of Watercress Sprout Extract and Soy-based Pure Genistein provides the formula's core brightening action, while a Chromanyl Palmitate-based Synthetic Peptide — a stabilised Vitamin E derivative — adds a further layer of antioxidant protection. Plum Pulp Extract rounds out the active brightening complex, working at the skin's surface to visibly fade existing discolouration through natural acids and brightening compounds.

The watercress targets oxidative stress triggers at their source by neutralising both reactive oxygen species (ROS) and reactive nitrogen species (RNS), while Pure Genistein acts directly on the melanogenesis pathway to inhibit pigment synthesis at the cellular level. The Chromanyl Peptide intercepts free radical chains before they can stimulate melanocyte activity, helping to prevent the environmental triggers that cause dark spots to recur.

Read less

30 ml

£287
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Get The Set
Biologique Recherche Intensive Pigmentation Correction Collection
Intensive Pigmentation Correction Collection

Serum PIGM 400
Creme PIGM 400

£589 £559

More Info

  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
Who it is for
Green tick
For you if

Pigmented Skin

Dull Skin

Red Cross
Not For you if
How to Apply
The pump bottle allows a more precise dosage for easy application. Delicately massage Sérum PIGM 400 onto the entire face or pigmented spot after your recommended Lotion P50 and before using Crème PIGM 400. Can be used on the face, forearms, chest and hands.
Ingredients

Scroll down the page for a full breakdown of the active ingredients.

Water (Aqua), Coco-Caprylate, Butylene Glycol, Pentylene Glycol, Glycerin, Lactobacillus/Wasabia Japonica Root Ferment Extract, Sodium Acrylates Copolymer, Soy Isoflavones, Hydrolyzed Prunus Domestica, Dictyopteris Membranacea Extract, Pancratium Maritimum Extract, Dimethylmethoxy Chromanyl Palmitate, Dimethylmethoxy Chromanol, Oligopeptide-68, Lepidium Sativum Sprout Extract, Glycine Soja (Soybean) Oil, Lecithin, Hydrogenated Lecithin, Polysorbate 80, Alcohol, Phenoxyethanol, Sodium Oleate, Disodium EDTA.

Contraindications: This product contains some photo-sensitising ingredients. We recommend applying SPF during the day and only applying it in the evening.


Please note: The ingredients listed in this product are subject to change as the formulation is updated. We aim to update the INCI list as soon as possible, but we encourage you to read the ingredient list on the product itself to ensure it's suitable for your personal use.

Smell & Texture

Smells Like: A neutral scent with hints of botanical notes.

Texture: Lightweight and gel-like texture

About the Brand
Brand logo
Founded in Paris in the late 1970s by biologist Yvan Allouche and physiotherapist Josette Allouche, Biologique Recherche began as a laboratory for bespoke, high-performance formulas for elite skin professionals. Their medical-grade precision and artisanal formulation, paired with consummate savoir-faire, underpin their reputation for outstanding, clinically proven results.

Biologique Recherche treats skin according to its Skin Instant©, the skin’s precise, evolving state. Each formula is loaded with active ingredients in exceptional concentrations, then prescribed to address those real-time needs. This precision approach corrects imbalances, restores function, and delivers visible, lasting transformation.

Cold-processed actives are the core of Biologique Recherche. Formulated at 18–25°C, this method avoids the 70°C heat of standard processing that breaks down actives. Botanical, marine, and biotechnological extracts stay intact for higher absorption, stronger repair, and better tolerance. Antioxidants, peptides, and enzymes remain stable, ensuring consistent, visible results.

The Benefits

  • - + Anti-Pigmentation
  • - + Photo-Protecting
  • - + Antioxidant
  • - + Skin Barrier Strengthening
  • - + Anti-Wrinkle
  • - + Firming & Lifting
  • - + Plumping
  • - + Regenerating
  • - + Scar-Repairing
  • - + Brightening (Energising)
Anti-Pigmentation

Dealing with pigmentation means targeting melanin overproduction to reduce dark spots and prevent new ones. Melanin production can be triggered by UV exposure, pollution, hormonal changes (like during pregnancy), and inflammation (from acne or cuts). This excess pigment is then transferred to surrounding cells in epidermis called keratinocytes, which then moves to the skin's surface, causing visible dark spots.

To treat hyperpigmentation, a personalised and consistent approach is needed. Our anti-pigmentation products include lightening agents to block tyrosinase (the enzyme that creates melanin), antioxidants to fight free radicals, and ingredients to speed up skin cell turnover, removing pigmented cells. Using broad-spectrum sun protection is crucial to prevent new pigmentation during treatment.

Photo-Protecting

Photo-protecting skincare at a cellular level focuses on defending the skin against the internal damage triggered by UV exposure, rather than simply blocking rays at the surface. Ultraviolet radiation generates free radicals and disrupts cellular DNA, accelerating collagen breakdown, inflammation, and premature ageing. Advanced formulations work by neutralising oxidative stress, supporting DNA repair mechanisms, and strengthening the skin’s natural defence systems to limit long-term damage. By preserving cellular integrity and maintaining healthy skin function, this approach helps prevent visible signs of photo-ageing—such as wrinkles, loss of firmness, and uneven tone.

Antioxidant

Antioxidant skincare is dedicated to protecting the skin against oxidative stress—one of the primary drivers of premature ageing and cellular damage—while preserving overall skin integrity and vitality. These formulations rely on potent molecules such as vitamin C, vitamin E, and polyphenols, which neutralize free radicals generated by UV exposure and environmental aggressors before they can compromise cellular structures like lipids, proteins, and DNA. Beyond defence, many antioxidants also support repair processes and enhance collagen stability, contributing to improved firmness, brightness and resilience. The result is skin that is not only shielded from ongoing damage but maintained in a healthier, more luminous state over time.

Skin Barrier Strengthening

Strengthening your skin barrier involves replenishing the key elements in the top layer of your skin (stratum corneum), leading to a stronger and healthier barrier. These essential elements include lipids (ceramides, fatty acids, and cholesterol) and Natural Moisturizing Factors (amino acids, hyaluronic acid, etc.). Various factors, such as incorrect skincare use, seasonal changes, and aesthetic treatments, can damage your skin barrier. When this happens, your skin loses excess water through Trans Epidermal Water Loss (T.E.W.L) and becomes less capable of defending against environmental stressors, resulting in dryness, sensitivity, and irritation.

A healthy skin barrier is crucial for overall skin health as it helps prevent hydration loss, protects against environmental damage, and reduces the risk of skin conditions like eczema and acne. By strengthening your skin barrier, you ensure your skin remains well-hydrated, resilient, and protected.

Anti-Wrinkle

Anti-wrinkle skincare is focused on both preventing and visibly reducing the formation of lines by targeting the structural and dynamic causes of wrinkles within the skin. Fine lines and deeper wrinkles develop as collagen and elastin decline, cell turnover slows and repeated facial movements create creases that become etched over time. Advanced formulations address these mechanisms through a combination of elastin-stimulating actives, smoothing peptides that help relax the appearance of expression lines, and deeply hydrating ingredients that plump the skin from within. By reinforcing the skin’s architecture while softening surface contractions and improving elasticity, anti-wrinkle skincare delivers a visibly smoother complexion.

Firming & Lifting

Firming & Lifting skincare is designed to restore strength, structure, and definition to the skin, creating a visibly tighter, more sculpted appearance. As the skin loses collagen and elasticity over time, it can begin to soften and sag, losing its natural contours. Advanced formulations work to rebuild this support from within—boosting firmness while helping to visibly lift and redefine the skin. The result is a smoother, more toned complexion with enhanced bounce and resilience, where facial contours appear sharper and elevated.

Plumping

Plumping involves using active ingredients to boost the production of key structural components like collagen, the dermal-epidermal junction and glycosaminoglycans (GAGs), giving your skin more volume and density. Collagen provides structural support and firmness, while the dermal-epidermal junction, a thin connective layer, ensures smooth, wrinkle-free skin by facilitating cell communication. GAGs, like hyaluronic acid, keep your skin hydrated and plump from within. By stimulating these components, active ingredients help restore your skin's plumpness and radiance.

Regenerating

Regenerating skincare actively stimulates the formation of new, healthier skin, working in alignment with the skin’s innate renewal processes. Central to this are growth factors—effectively encouraging the development of new skin tissue. Peptides complement this by acting as targeted messengers guiding the skin to rebuild with greater strength and structural integrity. Stem cell–derived actives further support this environment by delivering protective and regenerative signals that optimize cellular function and renewal. While these mechanisms are synonymous with advanced anti-ageing—improving firmness, elasticity and overall skin quality—they are equally valuable in addressing scarring, as they promote tissue repair, accelerate regeneration and help restore a smoother, more even skin surface.

Scar-Repairing

Anti-Scarring skincare targets the textured scars left by acne breakouts. These scars form due to inflammation disrupting collagen and elastin fibres leading to uneven healing and indented areas. Anti-Scarring actives harness growth factors and exfoliating actives to stimulate cell repair and regeneration, optimising the skin's healing process to reduce scar formation. They also effectively diminish older scars, improving overall skin texture and leaving you with a smoother complexion and significantly reduced scar visibility.

Brightening (Energising)

Brightening skincare involves using active ingredients to boost your blood circulation, detoxification and cellular energy. Improved blood circulation brings more essential nutrients and oxygen to your skin, while detoxification helps eliminate cell waste and impurities that can make your skin look dull. Certain active ingredients also enhance your skin's metabolism and regeneration. These combined actions restore your skin's vitality and radiant appearance, giving you a fresh, energised complexion.

  • - + Anti-Pigmentation
  • - + Photo-Protecting
  • - + Antioxidant
  • - + Skin Barrier Strengthening
  • - + Anti-Wrinkle
  • - + Firming & Lifting
  • - + Plumping
  • - + Regenerating
  • - + Scar-Repairing
  • - + Brightening (Energising)

Active Ingredients

  • - + Complex of Watercress Sprout Extract and Soy-based Pure Genistin
  • - + Chromanyl Palmitate-based Synthetic Peptide
  • - + Anti-ROS and anti-RNS Antioxidant
  • - + Plum Pulp Extract
  • - + Biomimetic Peptide
  • - + Sea Lily Extract
  • - + Sea Fern Extract
  • - + Wasabi Extract
Complex of Watercress Sprout Extract and Soy-based Pure Genistin

The Complex of Watercress Sprout Extract and Soy-based Pure Genistin targets dark spots by inhibiting melanin and lipofuscin (oxidized sebum) production. It also offers photo-protective properties, preventing premature ageing of skin cells.

Chromanyl Palmitate-based Synthetic Peptide

Chromanyl Palmitate-based Peptide is a potent lightening active that works by inhibiting tyrosinase activity, a primary enzyme responsible for melanin creation, resulting in reduced pigmentation marks. It also protects the skin cells form UV induced damage, ensuring skin is clearer of pigmentation and unified.

Anti-ROS and anti-RNS Antioxidant

This targeted antioxidant neutralises Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS), which are common free radicals induced by the environment. By doing so, it prevents melanin overproduction and the formation of lipofuscin, a pigment that results from oxidised sebum (oil); thus reducing the amount of pigment produced. Additionally, it detoxifies the skin and slows down cell ageing, allowing your skin to be more rejuvenated.

Plum Pulp Extract

Plum Pulp Extract is a lightening agent working on inhibiting melanogenesis (melanin overproduction) and melanin transfer to surrounding cells; thus inhibiting pigmentation from occurring. It also helps to strengthen the skin barrier and reduce Trans epidermal Water Loss (TEWL).

Biomimetic Peptide

Biomimetic Peptide is a compound derived from Thymopoietin, a hormone associated with youth. As we age, our production of this hormone decreases, leading to visible signs of ageing. Biomimetic Peptide mimics the effects of Thymopoietin, physiologically stimulating the regeneration of new, stronger skin similar to that of younger individuals. This results in denser, more resilient skin, reducing the appearance of ageing.

Sea Lily Extract

Sea Lily is a lightening agent that reduces the activity of melanocyte dendrites that are responsible for melanin transfer to surrounding cells; meaning that it inhibits pigmentation. It also contributes to normalising melanin production, which leads to visible improvement in the size and colour of existing pigmentation marks.

Sea Fern Extract

Sea Fern Extract is a lightening agent that targets the production and distribution of melanin into surrounding cells, helping to fade existing marks and prevent new ones from appearing, resulting in a brighter and more unified complexion.

Wasabi Extract

Wasabi in skincare is valued for its brightening and tone-enhancing properties, helping to revitalise dull, uneven skin. Rich in bioactive compounds such as isothiocyanates, it supports improved microcirculation and helps reduce oxidative stress, both of which contribute to a more radiant complexion. By energising the skin and enhancing its natural glow, wasabi helps promote a brighter, fresher, and more luminous appearance with improved overall clarity.

  • - + Complex of Watercress Sprout Extract and Soy-based Pure Genistin
  • - + Chromanyl Palmitate-based Synthetic Peptide
  • - + Anti-ROS and anti-RNS Antioxidant
  • - + Plum Pulp Extract
  • - + Biomimetic Peptide
  • - + Sea Lily Extract
  • - + Sea Fern Extract
  • - + Wasabi Extract
Age & UV Induced Pigmentation

Age and sun pigmentation, often known as hyperpigmentation or sunspots, is a common skin concern where excess melanin causes darkened patches. This can happen due to prolonged sun exposure and the natural ageing process, making our skin look older and less vibrant than we’d like.

Hyperpigmentation typically appears on areas most exposed to the sun, like the face, hands, and shoulders. Over time, UV radiation damages skin cells, leading to uneven skin tone and those familiar sunspots that can leave us feeling a little less confident in our complexion.

When the skin is exposed to UV radiation, it produces melanin as a defence mechanism. However, prolonged exposure and the effects of ageing can lead to an overproduction of melanin, resulting in dark spots and uneven skin tone. The good news is that consistent use of sun protection, antioxidants, and targeted treatments like retinoids or exfoliants can help.

These products work to reduce pigmentation, brighten the skin, and protect against further damage, helping to restore a more even and youthful appearance. With the right care, you can visibly reduce the appearance of age and sun pigmentation.

Regular use of targeted treatments helps brighten your complexion, improve skin tone, and give your skin a renewed radiance. It’s all about finding those little moments in your routine that not only protect but also restore your skin’s natural glow. Addressing pigmentation is a journey, but with patience and the right products, you can bring out the best in your skin.

By incorporating sunscreen, antioxidants, and gentle exfoliants into your daily routine, you’ll be protecting your skin from further damage while gradually reducing the appearance of existing spots. Embrace the process, and enjoy watching your skin transform into a brighter, more even version of itself, glowing with renewed confidence.

Spotlight

Age & UV Induced Pigmentation

Age and sun pigmentation, often known as hyperpigmentation or sunspots, is a common skin concern where excess melanin causes darkened patches. This can happen due to prolonged sun exposure and the natural ageing process, making our skin look older and less vibrant than we’d like.

Hyperpigmentation typically appears on areas most exposed to the sun, like the face, hands, and shoulders. Over time, UV radiation damages skin cells, leading to uneven skin tone and those familiar sunspots that can leave us feeling a little less confident in our complexion.

When the skin is exposed to UV radiation, it produces melanin as a defence mechanism. However, prolonged exposure and the effects of ageing can lead to an overproduction of melanin, resulting in dark spots and uneven skin tone. The good news is that consistent use of sun protection, antioxidants, and targeted treatments like retinoids or exfoliants can help.

These products work to reduce pigmentation, brighten the skin, and protect against further damage, helping to restore a more even and youthful appearance. With the right care, you can visibly reduce the appearance of age and sun pigmentation.

Regular use of targeted treatments helps brighten your complexion, improve skin tone, and give your skin a renewed radiance. It’s all about finding those little moments in your routine that not only protect but also restore your skin’s natural glow. Addressing pigmentation is a journey, but with patience and the right products, you can bring out the best in your skin.

By incorporating sunscreen, antioxidants, and gentle exfoliants into your daily routine, you’ll be protecting your skin from further damage while gradually reducing the appearance of existing spots. Embrace the process, and enjoy watching your skin transform into a brighter, more even version of itself, glowing with renewed confidence.

Why I love it

  • "The efficacy of Biologique Recherche relies not only on its science-driven approach to balancing and curing the skin, but on its prescriptive and tailored nature."

    X Natalie K-F

    Founder, Embassy of Beauty

  • Biologique Recherche Serum PIGM 400 30ml
    Biologique Recherche

    Serum PIGM 400

    £287

    Serum PIGM 400 by Biologique Recherche is a targeted anti-pigmentation serum formulated to prevent new dark spots from forming, reduce the appearance of existing hyperpigmentation and leave the complexion more even, unified and luminous.

    A complex of Watercress Sprout Extract and Soy-based Pure Genistein provides the formula's core brightening action, while a Chromanyl Palmitate-based Synthetic Peptide — a stabilised Vitamin E derivative — adds a further layer of antioxidant protection. Plum Pulp Extract rounds out the active brightening complex, working at the skin's surface to visibly fade existing discolouration through natural acids and brightening compounds.

    The watercress targets oxidative stress triggers at their source by neutralising both reactive oxygen species (ROS) and reactive nitrogen species (RNS), while Pure Genistein acts directly on the melanogenesis pathway to inhibit pigment synthesis at the cellular level. The Chromanyl Peptide intercepts free radical chains before they can stimulate melanocyte activity, helping to prevent the environmental triggers that cause dark spots to recur.

    View product