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Serum PIGM 400

Biologique Recherche
(2)

Serum PIGM 400

Biologique Recherche
(2)
Benefits
  • Anti-Pigmentation
  • Complexion-Unifying
  • Antioxidant
  • Photo-Protective
  • Barrier-Strengthening
The Biologique Recherche Serum PIGM 400 is an anti-pigmentation lightening treatment. It works to prevent dark spots from appearing and reduce the appearance of existing dark spots, leaving skin more even and unified.
Read more
The Biologique Recherche Serum PIGM 400 is an anti-pigmentation lightening treatment. It works to prevent dark spots from appearing and reduce the appearance of existing dark spots, leaving skin more even and unified.
Read less

30 ml

£285 £242
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More Info

  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
Who it is for
Green tick
For you if

Pigmented Skin

Dull Skin

Red Cross
Not For you if

Active Acne

Reactive Skin

Sensitive Skin

Rosacea


Not sure? Consult an expert.

How to Apply
The pump bottle allows a more precise dosage for easy application. Delicately massage Sérum PIGM 400 onto the entire face or pigmented spot after your recommended Lotion P50 and before using Crème PIGM 400. Can be used on the face, forearms, chest and hands.
Ingredients

Scroll down the page for a full breakdown of the active ingredients.

Water (Aqua), Coco-Caprylate, Butylene Glycol, Pentylene Glycol, Glycerin, Lactobacillus/Wasabia Japonica Root Ferment Extract, Sodium Acrylates Copolymer, Soy Isoflavones, Hydrolyzed Prunus Domestica, Dictyopteris Membranacea Extract, Pancratium Maritimum Extract, Dimethylmethoxy Chromanyl Palmitate, Dimethylmethoxy Chromanol, Oligopeptide-68, Lepidium Sativum Sprout Extract, Glycine Soja (Soybean) Oil, Lecithin, Hydrogenated Lecithin, Polysorbate 80, Alcohol, Phenoxyethanol, Sodium Oleate, Disodium EDTA.

Contraindications: This product contains some photo-sensitising ingredients. We recommend applying SPF during the day and only applying it in the evening.


Please note: The ingredients listed in this product are subject to change as the formulation is updated. We aim to update the INCI list as soon as possible, but we encourage you to read the ingredient list on the product itself to ensure it's suitable for your personal use.

Smell & Texture

Smells Like: A neutral scent with hints of botanical notes.

Texture: Lightweight and gel-like texture

About the Brand
Brand logo
Founded in Paris in the late 1970s by biologist Yvan Allouche and physiotherapist Josette Allouche, Biologique Recherche began as a laboratory for bespoke, high-performance formulas for elite skin professionals. Their medical-grade precision and artisanal formulation, paired with consummate savoir-faire, underpin their reputation for outstanding, clinically proven results.

Biologique Recherche treats skin according to its Skin Instant©, the skin’s precise, evolving state. Each formula is loaded with active ingredients in exceptional concentrations, then prescribed to address those real-time needs. This precision approach corrects imbalances, restores function, and delivers visible, lasting transformation.

Cold-processed actives are the core of Biologique Recherche. Formulated at 18–25°C, this method avoids the 70°C heat of standard processing that breaks down actives. Botanical, marine, and biotechnological extracts stay intact for higher absorption, stronger repair, and better tolerance. Antioxidants, peptides, and enzymes remain stable, ensuring consistent, visible results.

The Benefits

  • - + Anti-Pigmentation
  • - + Complexion-Unifying (Anti-Blotchiness)
  • - + Antioxidant
  • - + Skin-Barrier Supporting
  • - + Regenerating
  • - + Photo-Protecting
Anti-Pigmentation

Dealing with pigmentation means targeting melanin overproduction to reduce dark spots and prevent new ones. Melanin production can be triggered by UV exposure, pollution, hormonal changes (like during pregnancy), and inflammation (from acne or cuts). This excess pigment is then transferred to surrounding cells in epidermis called keratinocytes, which then moves to the skin's surface, causing visible dark spots.

To treat hyperpigmentation, a personalised and consistent approach is needed. Our anti-pigmentation products include lightening agents to block tyrosinase (the enzyme that creates melanin), antioxidants to fight free radicals, and ingredients to speed up skin cell turnover, removing pigmented cells. Using broad-spectrum sun protection is crucial to prevent new pigmentation during treatment.

Complexion-Unifying (Anti-Blotchiness)

Evening skin tone is all about reducing blotchiness and achieving a more uniform complexion. Skincare products designed for this purpose use a blend of active ingredients, including soothing agents, anti-pigmentation compounds, antioxidants, and skin-restoring elements. These ingredients work together to diminish redness, inflammation, and pigment irregularities caused by inflammation, while also strengthening and protecting your skin against environmental irritants and future damage. This promotes healing and resilience, leaving your skin more balanced, radiant, and beautiful.

Antioxidant

Antioxidant Protection shields your skin and preserves its youthful glow. It refers to a defence system that protects against harmful molecules and keeps your complexion healthy and radiant. Free radicals, those incredibly reactive molecules, come from everyday sources like sunlight, diet, smoking, and pollution. They attack healthy cells, accelerating skin ageing, causing wrinkles, loss of firmness, pigmentation, and dullness.

Incorporating antioxidants, such as vitamins C and E, into your skincare routine creates a protective shield on your skin. These powerful ingredients neutralise free radicals, preventing them from causing damage. The result is skin that stays youthful, firm, and luminous.

Skin-Barrier Supporting

Restoring your skin barrier involves replenishing the key elements found in the top layer of your skin (stratum corneum), resulting in a stronger and healthier barrier. These essential elements include lipids (ceramides, fatty acids, and cholesterol) and Natural Moisturising Factors (amino acids, hyaluronic acid, etc.). Various factors such as incorrect skincare use, seasonal changes, and aesthetic treatments can damage your skin barrier. When this happens, your skin loses excess water through Trans Epidermal Water Loss (T.E.W.L) and becomes less able to defend against environmental stresses, leading to dryness, sensitivity, and irritation.

A healthy skin barrier is crucial for maintaining overall skin health, as it helps prevent moisture loss, protects against environmental damage, and reduces the risk of skin conditions like eczema and acne. Replenishing these essential elements ensures your skin stays hydrated, resilient, and protected.

Regenerating

Regenerative benefits work to restore and renew your skin at a cellular level. By stimulating cell turnover and boosting collagen and elastin production, they help repair damage, diminish fine lines and wrinkles, and improve overall skin texture. The result is a rejuvenated, firmer, and more youthful complexion that radiates vitality.

Photo-Protecting

Photo-protective products offer strong protection against harmful UV radiation. They create a defensive barrier on your skin, preventing sunburn, premature ageing, and DNA damage from sun exposure. These products help reduce the risk of photoageing, including fine lines, wrinkles, and dark spots, while also supporting your skin’s natural repair processes to minimize the impact of any existing sun damage.

  • - + Anti-Pigmentation
  • - + Complexion-Unifying (Anti-Blotchiness)
  • - + Antioxidant
  • - + Skin-Barrier Supporting
  • - + Regenerating
  • - + Photo-Protecting

Active Ingredients

  • - + Biomimetic Peptide
  • - + Chromanyl Palmitate-based Synthetic Peptide
  • - + Sea Fern Extract
  • - + Sea Lily Extract
  • - + Wasabi Extract
  • - + Plum Pulp Extract
  • - + Anti-ROS and anti-RNS Antioxidant
  • - + Complex of Watercress Sprout Extract and Soy-based Pure Genistin
Biomimetic Peptide

Biomimetic Peptide is a compound derived from Thymopoietin, a hormone associated with youth. As we age, our production of this hormone decreases, leading to visible signs of ageing. Biomimetic Peptide mimics the effects of Thymopoietin, physiologically stimulating the regeneration of new, stronger skin similar to that of younger individuals. This results in denser, more resilient skin, reducing the appearance of ageing.

Chromanyl Palmitate-based Synthetic Peptide

Chromanyl Palmitate-based Peptide is a potent lightening active that works by inhibiting tyrosinase activity, a primary enzyme responsible for melanin creation, resulting in reduced pigmentation marks. It also protects the skin cells form UV induced damage, ensuring skin is clearer of pigmentation and unified.

Sea Fern Extract

Sea Fern Extract is a lightening agent that targets the production and distribution of melanin into surrounding cells, helping to fade existing marks and prevent new ones from appearing, resulting in a brighter and more unified complexion.

Sea Lily Extract

Sea Lily is a lightening agent that reduces the activity of melanocyte dendrites that are responsible for melanin transfer to surrounding cells; meaning that it inhibits pigmentation. It also contributes to normalising melanin production, which leads to visible improvement in the size and colour of existing pigmentation marks.

Wasabi Extract

Wasabi has powerful antioxidant and antiseptic properties, helping to protect skin cells from free radical damage and support skin healing.

Plum Pulp Extract

Plum Pulp Extract is a lightening agent working on inhibiting melanogenesis (melanin overproduction) and melanin transfer to surrounding cells; thus inhibiting pigmentation from occurring. It also helps to strengthen the skin barrier and reduce Trans epidermal Water Loss (TEWL).

Anti-ROS and anti-RNS Antioxidant

This targeted antioxidant neutralises Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS), which are common free radicals induced by the environment. By doing so, it prevents melanin overproduction and the formation of lipofuscin, a pigment that results from oxidised sebum (oil); thus reducing the amount of pigment produced. Additionally, it detoxifies the skin and slows down cell ageing, allowing your skin to be more rejuvenated.

Complex of Watercress Sprout Extract and Soy-based Pure Genistin

The Complex of Watercress Sprout Extract and Soy-based Pure Genistin targets dark spots by inhibiting melanin and lipofuscin (oxidized sebum) production. It also offers photo-protective properties, preventing premature ageing of skin cells.

  • - + Biomimetic Peptide
  • - + Chromanyl Palmitate-based Synthetic Peptide
  • - + Sea Fern Extract
  • - + Sea Lily Extract
  • - + Wasabi Extract
  • - + Plum Pulp Extract
  • - + Anti-ROS and anti-RNS Antioxidant
  • - + Complex of Watercress Sprout Extract and Soy-based Pure Genistin

Spotlight

Age & UV Induced Pigmentation

Age and sun pigmentation, often known as hyperpigmentation or sunspots, is a common skin concern where excess melanin causes darkened patches. This can happen due to prolonged sun exposure and the natural ageing process, making our skin look older and less vibrant than we’d like. Hyperpigmentation typically appears on areas most exposed to the sun, like the face, hands, and shoulders. Over time, UV radiation damages skin cells, leading to uneven skin tone and those familiar sunspots that can leave us feeling a little less confident in our complexion. When the skin is exposed to UV radiation, it produces melanin as a defence mechanism. However, prolonged exposure and the effects of ageing can lead to an overproduction of melanin, resulting in dark spots and uneven skin tone. The good news is that consistent use of sun protection, antioxidants, and targeted treatments like retinoids or exfoliants can help. These products work to reduce pigmentation, brighten the skin, and protect against further damage, helping to restore a more even and youthful appearance. With the right care, you can visibly reduce the appearance of age and sun pigmentation. Regular use of targeted treatments helps brighten your complexion, improve skin tone, and give your skin a renewed radiance. It’s all about finding those little moments in your routine that not only protect but also restore your skin’s natural glow. Addressing pigmentation is a journey, but with patience and the right products, you can bring out the best in your skin. By incorporating sunscreen, antioxidants, and gentle exfoliants into your daily routine, you’ll be protecting your skin from further damage while gradually reducing the appearance of existing spots. Embrace the process, and enjoy watching your skin transform into a brighter, more even version of itself, glowing with renewed confidence.

Clinical Proofs

Clinical Proofs

Why I love it

  • "The efficacy of Biologique Recherche relies not only on its science-driven approach to balancing and curing the skin, but on its prescriptive and tailored nature."

    X Natalie K-F

    Founder, Embassy of Beauty

    • Biologique Recherche Serum PIGM 400 30ml
    Biologique Recherche

    Serum PIGM 400

    £285 £242

    The Biologique Recherche Serum PIGM 400 is an anti-pigmentation lightening treatment. It works to prevent dark spots from appearing and reduce the appearance of existing dark spots, leaving skin more even and unified.

    View product