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Prebiotic Regenerating Night Cream

Prebiotic Regenerating Night Cream
Demain Beauty
Benefits
  • Microbiome Balancing
  • Anti-Wrinkle
  • Plumping
  • Firming
  • Lifting
  • Hydrating
  • Barrier-Strengthening
  • Antioxidant
  • Nourishing

Launching mid-June. Join the waitlist below.

The Demain Beauty Prebiotic Regenerating Night Cream is a deeply nourishing overnight treatment that targets wrinkles, loss of firmness and cellular fatigue, combining a collagen-stimulating active complex with a restorative oil blend, microbiome-rebalancing ferments and a natural endorphin-activating fragrance to work in synchrony with the skin's own nocturnal repair cycle.

Lactococcus Ferment Lysate and Leuconostoc Radish Root Ferment Filtrate form the pre and postbiotic microbiome complex — the ferment lysate stimulates collagen synthesis, improves skin elasticity, firms and redensifies the dermis while oxygenating cells for a visibly brighter complexion, while the radish root ferment rebalances and reinforces the skin's bacterial ecosystem throughout the night.

Sodium Hyaluronate and Saccharide Isomerate form the core hydrating duo — Hyaluronic Acid plumps the epidermis from within, visibly reducing wrinkle depth and restoring suppleness overnight, while Saccharide Isomerate mimics the skin's own natural hydration factors for lasting, deeply anchored hydration that persists into the following morning.

Milk Thistle Oil and Shea Butter form the restorative nourishing complex — Milk Thistle, rich in over 70% unsaturated fatty acids, actively supports cellular reconstitution and barrier repair overnight, while Shea Butter deeply nourishes, softens and protects with its concentrated blend of vitamins A, E and F.

Ribose energises skin cells at a mitochondrial level to support overnight renewal, Jania Rubens (Red Algae) Extract delivers a concentrated marine mineral boost to revitalise and firm, and Lavandula Stoechas (Lavender) Extract calms and soothes, while Tocopherol, Beta-Sitosterol and Chlorella Vulgaris provide a final layer of antioxidant and barrier protection.

Read more

Launching mid-June. Join the waitlist below.

The Demain Beauty Prebiotic Regenerating Night Cream is a deeply nourishing overnight treatment that targets wrinkles, loss of firmness and cellular fatigue, combining a collagen-stimulating active complex with a restorative oil blend, microbiome-rebalancing ferments and a natural endorphin-activating fragrance to work in synchrony with the skin's own nocturnal repair cycle.

Lactococcus Ferment Lysate and Leuconostoc Radish Root Ferment Filtrate form the pre and postbiotic microbiome complex — the ferment lysate stimulates collagen synthesis, improves skin elasticity, firms and redensifies the dermis while oxygenating cells for a visibly brighter complexion, while the radish root ferment rebalances and reinforces the skin's bacterial ecosystem throughout the night.

Sodium Hyaluronate and Saccharide Isomerate form the core hydrating duo — Hyaluronic Acid plumps the epidermis from within, visibly reducing wrinkle depth and restoring suppleness overnight, while Saccharide Isomerate mimics the skin's own natural hydration factors for lasting, deeply anchored hydration that persists into the following morning.

Milk Thistle Oil and Shea Butter form the restorative nourishing complex — Milk Thistle, rich in over 70% unsaturated fatty acids, actively supports cellular reconstitution and barrier repair overnight, while Shea Butter deeply nourishes, softens and protects with its concentrated blend of vitamins A, E and F.

Ribose energises skin cells at a mitochondrial level to support overnight renewal, Jania Rubens (Red Algae) Extract delivers a concentrated marine mineral boost to revitalise and firm, and Lavandula Stoechas (Lavender) Extract calms and soothes, while Tocopherol, Beta-Sitosterol and Chlorella Vulgaris provide a final layer of antioxidant and barrier protection.

Read less

40 ml

£52
Free Standard Delivery
(£75)
Free Next Day Delivery
(£150)
Free Samples
(£200)
Spend £75 more for Free Standard Delivery

More Info

  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
Who it is for
Green tick
For you if

Microbiome Balancing

Wrinkles

Loss of Volume

Loss of Firmness

Barrier Strengthening

Dry Skin

Eczema & Psoriasis

Sensitive Skin

Reactive Skin

Rosacea

Dehydrated Skin

Red Cross
Not For you if
How to Apply
Apply morning and evening to clean skin, massaging gently into the face and neck using circular movements to encourage absorption and stimulate circulation.
Ingredients

Aqua (Water), Coconut Alkanes, Glycerin, Helianthus Annuus (Sunflower) Hybrid Oil*, Lactococcus Ferment Lysate, Pentylene Glycol, Arachidyl Alcohol, Silybum Marianum (Milk Thistle) Seed Oil*, Coco Caprylate/Caprate, Zea Mays (Corn) Starch*, Behenyl Alcohol, Butyrospermum Parkii (Shea) Butter*, Leuconostoc/Radish Root Ferment Filtrate, Sodium Hyaluronate, Aloe Barbadensis (Aloe) Leaf Juice Powder*, Lactic Acid, Squalene, Chlorella Vulgaris Extract, Helianthus Annuus (Sunflower) Seed Oil, Tocopherol, Arachidyl Glucoside, Ribose, Xanthan Gum, Maris Aqua (Sea Water), Citric Acid, Phenethyl Alcohol, Laminaria Digitata Extract, Sodium Chloride, Beta-Sitosterol, Jania Rubens Extract, Phenylpropanol, Levulinic Acid, Sodium Levulinate, Lavandula Stoechas Extract, Saccharide Isomerate, Parfum (Fragrance), Limonene, Linalool.

Please note: The ingredients listed in this product are subject to change as the formulation is updated. We aim to update the INCI list as soon as possible, but we encourage you to read the ingredient list on the product itself to ensure it's suitable for your personal use.

Smell & Texture

Smell: A comforting orange blossom fragrance enriched with a natural endorphin activator — gently relaxing the senses and easing the mind into sleep.

Texture: A cushioned, caress-like cream that melts effortlessly into the skin — deeply nourishing without heaviness or residue.

About the Brand
Brand logo
Demain Beauty is not simply a skincare brand — it is a conviction, a movement, and a quiet revolution in the way we understand skin health. Born in France and certified organic by Ecocert's most rigorous COSMOS ORGANIC standard, every product in the Demain range is crafted with a singular belief: that beauty should never come at a cost to your health. Multi-award-winning and backed by scientifically proven results, Demain Beauty has carved its own space in the landscape of clean, conscious skincare — one that is as committed to what goes into a formula as to what is deliberately left out. With a loyal community of devotees, glowing clinical results, and a growing presence in the world's most discerning beauty circles, this is a brand that has earned its place not through noise, but through results.

The Benefits

  • - + Microbiome Balancing
  • - + Anti-Wrinkle
  • - + Plumping
  • - + Firming & Lifting
  • - + Hydrating
  • - + Reduces Trans Epidermal Water Loss
  • - + Skin Barrier Strengthening
  • - + Antioxidant
  • - + Nourishing
  • - + Photo-Protecting
Microbiome Balancing

Microbiome Balancing skincare focuses on supporting the skin’s ecosystem through a precise combination of prebiotics, probiotics, and postbiotics—each playing a distinct and complementary role. Prebiotics act as a targeted nutrient source, feeding and promoting the growth of beneficial microorganisms to maintain balance within the skin’s microbiome. Probiotics then introduce and reinforce these beneficial bacteria, helping to strengthen the skin’s natural defenses and reduce the presence of harmful strains. Postbiotics, the bioactive compounds produced through this process, enhance overall skin function by supporting barrier strength, improving hydration, and calming inflammation. Together, this synergistic approach stabilises the skin environment, resulting in a complexion that is clearer, more resilient, and visibly healthier.

Anti-Wrinkle

Anti-wrinkle skincare is focused on both preventing and visibly reducing the formation of lines by targeting the structural and dynamic causes of wrinkles within the skin. Fine lines and deeper wrinkles develop as collagen and elastin decline, cell turnover slows and repeated facial movements create creases that become etched over time. Advanced formulations address these mechanisms through a combination of elastin-stimulating actives, smoothing peptides that help relax the appearance of expression lines, and deeply hydrating ingredients that plump the skin from within. By reinforcing the skin’s architecture while softening surface contractions and improving elasticity, anti-wrinkle skincare delivers a visibly smoother complexion.

Plumping

Plumping involves using active ingredients to boost the production of key structural components like collagen, the dermal-epidermal junction and glycosaminoglycans (GAGs), giving your skin more volume and density. Collagen provides structural support and firmness, while the dermal-epidermal junction, a thin connective layer, ensures smooth, wrinkle-free skin by facilitating cell communication. GAGs, like hyaluronic acid, keep your skin hydrated and plump from within. By stimulating these components, active ingredients help restore your skin's plumpness and radiance.

Firming & Lifting

Firming & Lifting skincare is designed to restore strength, structure, and definition to the skin, creating a visibly tighter, more sculpted appearance. As the skin loses collagen and elasticity over time, it can begin to soften and sag, losing its natural contours. Advanced formulations work to rebuild this support from within—boosting firmness while helping to visibly lift and redefine the skin. The result is a smoother, more toned complexion with enhanced bounce and resilience, where facial contours appear sharper and elevated.

Hydrating

Hydration is a fundamental part of healthy skincare, focusing on maintaining and restoring the skin’s water content. Well-hydrated skin appears plump, smooth and radiant, while dehydration can lead to dullness, tightness, fine lines and increased sensitivity.
Hydrating the skin can work through a fascinating mix of ingredients with different roles. Humectants like hyaluronic acid and glycerin act like water magnets, pulling water into the skin to instantly plump and smooth, while Natural Moisturizing Factors (NMFs)—such as urea, amino acids and sodium PCA—mimic the skin’s own hydration system, helping it hold onto water and stay balanced from within.
Adding humectants like hyaluronic acid to your routine will restore your skin's healthy glow, minimize fine lines, and provide a plumping effect.

Reduces Trans Epidermal Water Loss

Reducing Trans Epidermal Water Loss (TEWL) is key to maintaining your skin’s optimal hydration levels. By strengthening your skin’s natural barrier, these ingredients prevent water from escaping, keeping your skin well-hydrated and plump. The result is a smoother, more supple complexion with improved texture and resilience, giving you a healthier, more radiant look.

Skin Barrier Strengthening

Strengthening your skin barrier involves replenishing the key elements in the top layer of your skin (stratum corneum), leading to a stronger and healthier barrier. These essential elements include lipids (ceramides, fatty acids, and cholesterol) and Natural Moisturizing Factors (amino acids, hyaluronic acid, etc.). Various factors, such as incorrect skincare use, seasonal changes, and aesthetic treatments, can damage your skin barrier. When this happens, your skin loses excess water through Trans Epidermal Water Loss (T.E.W.L) and becomes less capable of defending against environmental stressors, resulting in dryness, sensitivity, and irritation.

A healthy skin barrier is crucial for overall skin health as it helps prevent hydration loss, protects against environmental damage, and reduces the risk of skin conditions like eczema and acne. By strengthening your skin barrier, you ensure your skin remains well-hydrated, resilient, and protected.

Antioxidant

Antioxidant skincare is dedicated to protecting the skin against oxidative stress—one of the primary drivers of premature ageing and cellular damage—while preserving overall skin integrity and vitality. These formulations rely on potent molecules such as vitamin C, vitamin E, and polyphenols, which neutralize free radicals generated by UV exposure and environmental aggressors before they can compromise cellular structures like lipids, proteins, and DNA. Beyond defence, many antioxidants also support repair processes and enhance collagen stability, contributing to improved firmness, brightness and resilience. The result is skin that is not only shielded from ongoing damage but maintained in a healthier, more luminous state over time.

Nourishing

Nourishing skincare focuses on replenishing the skin with essential lipids, nutrients, and bioactive compounds to restore comfort, resilience, and optimal function. When the skin is depleted—whether through environmental stress, over-exfoliation, or natural ageing—it can become dry, fragile, and less able to protect itself. Nourishing formulations work to rebuild the lipid barrier using ingredients rich in fatty acids, vitamins, and antioxidants, helping to reinforce the skin’s structure while supporting repair and reducing moisture loss. By restoring what the skin lacks, this approach leaves it softer, stronger, and more supple.

Photo-Protecting

Photo-protecting skincare at a cellular level focuses on defending the skin against the internal damage triggered by UV exposure, rather than simply blocking rays at the surface. Ultraviolet radiation generates free radicals and disrupts cellular DNA, accelerating collagen breakdown, inflammation, and premature ageing. Advanced formulations work by neutralising oxidative stress, supporting DNA repair mechanisms, and strengthening the skin’s natural defence systems to limit long-term damage. By preserving cellular integrity and maintaining healthy skin function, this approach helps prevent visible signs of photo-ageing—such as wrinkles, loss of firmness, and uneven tone.

  • - + Microbiome Balancing
  • - + Anti-Wrinkle
  • - + Plumping
  • - + Firming & Lifting
  • - + Hydrating
  • - + Reduces Trans Epidermal Water Loss
  • - + Skin Barrier Strengthening
  • - + Antioxidant
  • - + Nourishing
  • - + Photo-Protecting

Active Ingredients

  • - + LACTOCOCCUS FERMENT LYSATE (PROBIOTIC) 
  • - + Ribose
  • - + Radish Root Ferment
  • - + Low Molecular Weight Hyaluronic Acid
  • - + Saccharide Isomerate (PENTAVITIN)
  • - + Milk Thistle Oil
  • - + Shea Butter
  • - + Algae Extract
  • - + Red Algae Extract
LACTOCOCCUS FERMENT LYSATE (PROBIOTIC) 

Fermented Lactococcus Ferment Lysate is derived from the fermentation of the Lactococcus Lactis bacteria. This process releases natural sugars that serve as probiotics on the skin, enhancing the balance of the skin microbiome. It promotes the growth of beneficial microorganisms while safeguarding against harmful bacteria. In addition to supporting the microbiome, it functions as a natural preservative and skin softener.

Ribose

Ribose works in precise synchrony with the skin's own circadian rhythm — boosting the energy available for collagen production, accelerating cellular turnover and supporting the structural processes that restore firmness, elasticity and radiance from within.

Radish Root Ferment

Radish Root Ferment acts as a targeted prebiotic — selectively feeding and strengthening beneficial bacteria on the skin's surface while simultaneously inhibiting the growth of pathogenic microorganisms. This dual action supports a more balanced, diverse and resilient skin microbiome, creating the conditions in which the skin's own natural defence and repair mechanisms can function optimally.

Low Molecular Weight Hyaluronic Acid

Low Molecular Weight Hyaluronic Acid (LMW-HA) is a smaller, more penetrative form of hyaluronic acid. Unlike high molecular weight forms that primarily hydrate the skin’s surface, LMW-HA has the ability to penetrate deeper into the epidermis, where it attracts and binds water to maintain optimal moisture levels from within. This deep hydration helps improve skin elasticity, firmness and smoothness, while reducing the appearance of fine lines and dehydration-induced wrinkles. Additionally, it enhances overall suppleness, making the complexion look plumper and more resilient. It is ideal for dehydrated, dull or mature skin, and especially those in need of long-lasting hydration and improved texture.

Saccharide Isomerate (PENTAVITIN)

Saccharide Isomerate, also known as PentavitinÆ, is a carbohydrate complex derived from plants that closely resembles those found in human skin. It serves multiple functions in skincare: first, it acts as a prebiotic, supporting a healthy balance of microorganisms on the skin's surface, which is crucial for maintaining skin health.

Secondly, Saccharide Isomerate functions as a powerful humectant. This means it attracts moisture from the environment and binds it to the skin, acting like a "water magnet." This ability helps to deeply hydrate the skin, making it appear plump, smooth, and intensely moisturised.

Studies have shown that Saccharide Isomerate can increase skin hydration levels for up to 72 hours after application, making it an effective ingredient for providing long-lasting hydration and maintaining skin moisture balance.

Milk Thistle Oil

Milk Thistle Oil actively supports cellular reconstitution and barrier repair, replenishing the skin's hydrolipidic film and restoring elasticity and suppleness to skin that has become dry, depleted or visibly aged. Its high Vitamin E content neutralises free radical damage and protects against environmental oxidative stress, while its omega 6 fatty acids deeply nourish and strengthen the skin's natural resilience over time.

Shea Butter

Shea Butter is renowned for its deeply nourishing benefits. It helps to repair and strengthen a weakened skin barrier while enhancing water retention. It quickly replenishes and restores dry, dehydrated and fragile skins.

Algae Extract

Algae Extract is a nutrient-dense marine active, rich in antioxidants, amino acids, and essential minerals that help protect skin from environmental damage. Its high antioxidant capacity neutralises free radicals generated by UV exposure and pollution, reducing oxidative stress that accelerates skin ageing. Naturally hydrating polysaccharides draw and retain moisture, reinforcing the skin barrier and improving elasticity. The combination of protective and replenishing actions helps maintain a smoother, more resilient, and plumper complexion.

Red Algae Extract

Red Algae Extract actively supports collagen and elastin synthesis, helping to firm, redensify and restore structural integrity to skin that has lost elasticity and tone with age or environmental damage. Its polysaccharide content forms a breathable, protective film on the skin's surface that locks in hydration, reinforces barrier function and shields against transepidermal water loss, while its naturally occurring antioxidants neutralise free radical damage and protect against the oxidative stress that accelerates visible ageing.

  • - + LACTOCOCCUS FERMENT LYSATE (PROBIOTIC) 
  • - + Ribose
  • - + Radish Root Ferment
  • - + Low Molecular Weight Hyaluronic Acid
  • - + Saccharide Isomerate (PENTAVITIN)
  • - + Milk Thistle Oil
  • - + Shea Butter
  • - + Algae Extract
  • - + Red Algae Extract
Pre, Pro & Postbiotics

The skin's microbiome — the vast, complex community of bacteria, fungi and microorganisms that live on its surface — is one of its most powerful and most overlooked defence systems. When balanced, it regulates inflammation, protects against environmental aggressors, supports barrier function and keeps the complexion clear and resilient. When disrupted by harsh cleansers, antibiotics, pollution or stress, the consequences show up directly on the skin — as sensitivity, breakouts, redness and accelerated ageing.
Prebiotics feed and strengthen the beneficial bacteria already present on the skin, creating the conditions for a thriving, diverse microbiome. Probiotics — whether live or tyndallized — introduce beneficial bacterial strains that actively rebalance flora, calm inflammation and reinforce the skin's natural defences. Postbiotics are the bioactive byproducts produced when probiotics ferment, delivering concentrated anti-inflammatory, antioxidant and barrier-repairing benefits directly to the skin. Together, the three work in intelligent synergy — nurturing, rebalancing and fortifying the microbiome at every level for skin that is not just visibly healthier, but fundamentally stronger from the inside out.

Spotlight

Pre, Pro & Postbiotics

The skin's microbiome — the vast, complex community of bacteria, fungi and microorganisms that live on its surface — is one of its most powerful and most overlooked defence systems. When balanced, it regulates inflammation, protects against environmental aggressors, supports barrier function and keeps the complexion clear and resilient. When disrupted by harsh cleansers, antibiotics, pollution or stress, the consequences show up directly on the skin — as sensitivity, breakouts, redness and accelerated ageing.
Prebiotics feed and strengthen the beneficial bacteria already present on the skin, creating the conditions for a thriving, diverse microbiome. Probiotics — whether live or tyndallized — introduce beneficial bacterial strains that actively rebalance flora, calm inflammation and reinforce the skin's natural defences. Postbiotics are the bioactive byproducts produced when probiotics ferment, delivering concentrated anti-inflammatory, antioxidant and barrier-repairing benefits directly to the skin. Together, the three work in intelligent synergy — nurturing, rebalancing and fortifying the microbiome at every level for skin that is not just visibly healthier, but fundamentally stronger from the inside out.

Why I love it

  • What sets Demain Beauty apart is how effortlessly these formulas translate the science of the microbiome into results you can actually see and feel. Each product is built around a sophisticated pre, pro and postbiotic complex — working in genuine harmony with the skin's own ecosystem rather than disrupting it, stripping it back or overwhelming it with unnecessary actives. It is intelligent, considered skincare that respects the skin's natural intelligence in return.

    X Natalie K-F

    Founder, Embassy of Beauty