La Grande Creme
Benefits
Biologique Recherche La Grande Creme is an advanced anti-ageing cream formulated to reverse signs of ageing. It harnesses potent actives to promote cellular regeneration, repair DNA damage and leave skin brighter, firmer and protected.
EpigenActiv — an advanced pentapeptide that targets epidermal growth factor receptors and inhibits microRNAs that impede skin repair with age — accelerates cellular renewal and regeneration to promote a more youthful appearance while activating cellular detoxification.
Mimosa Tenuiflora Extract aids in stimulating tissue repair to regenerate new tissue, with antimicrobial and healing benefits that protect and repair the skin. Peony Extract works on deeper layers of the skin to prevent early adipocyte loss and migration, preserving facial volume, density and facial contours.
Peony Extract works on deeper layers of the skin to prevent early adipocyte loss and migration, preserving facial volume, density and facial contours.
Centella Asiatica, the Complex of Matrikines and a broad spectrum of antioxidants and peptides — including Argireline, Carcinine and Stabilised Vitamin C — work in concert to firm, relax expression lines, brighten and protect, producing a comprehensively rejuvenated and visibly younger-looking complexion.
Biologique Recherche La Grande Creme is an advanced anti-ageing cream formulated to reverse signs of ageing. It harnesses potent actives to promote cellular regeneration, repair DNA damage and leave skin brighter, firmer and protected.
EpigenActiv — an advanced pentapeptide that targets epidermal growth factor receptors and inhibits microRNAs that impede skin repair with age — accelerates cellular renewal and regeneration to promote a more youthful appearance while activating cellular detoxification.
Mimosa Tenuiflora Extract aids in stimulating tissue repair to regenerate new tissue, with antimicrobial and healing benefits that protect and repair the skin. Peony Extract works on deeper layers of the skin to prevent early adipocyte loss and migration, preserving facial volume, density and facial contours.
Peony Extract works on deeper layers of the skin to prevent early adipocyte loss and migration, preserving facial volume, density and facial contours.
Centella Asiatica, the Complex of Matrikines and a broad spectrum of antioxidants and peptides — including Argireline, Carcinine and Stabilised Vitamin C — work in concert to firm, relax expression lines, brighten and protect, producing a comprehensively rejuvenated and visibly younger-looking complexion.
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More Info
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Who it is for
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How to Apply
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Ingredients
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Smell & Texture
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About the Brand
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Who it is for
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How to Apply
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Ingredients
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Smell & Texture
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About the Brand
For you if
Not For you if
Biologique Recherche treats skin according to its Skin Instant©, the skin’s precise, evolving state. Each formula is loaded with active ingredients in exceptional concentrations, then prescribed to address those real-time needs. This precision approach corrects imbalances, restores function, and delivers visible, lasting transformation.
Cold-processed actives are the core of Biologique Recherche. Formulated at 18–25°C, this method avoids the 70°C heat of standard processing that breaks down actives. Botanical, marine, and biotechnological extracts stay intact for higher absorption, stronger repair, and better tolerance. Antioxidants, peptides, and enzymes remain stable, ensuring consistent, visible results.
The Benefits
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Skin Barrier Strengthening
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Anti-Bacterial
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Anti-Wrinkle
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Firming & Lifting
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Plumping
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Regenerating
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Scar-Repairing
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Brightening (Energising)
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Anti-Redness
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Antioxidant
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Anti-Inflammatory
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Photo-Protecting
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Cell Communication
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Anti-Pigmentation
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Injectable Effect
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Anti-Ageing (Glycation)
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Microbiome Balancing
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Hydrating
Skin Barrier Strengthening
Anti-Bacterial
Anti-Wrinkle
Firming & Lifting
Plumping
Regenerating
Scar-Repairing
Brightening (Energising)
Anti-Redness
Antioxidant
Anti-Inflammatory
Photo-Protecting
Cell Communication
Anti-Pigmentation
Injectable Effect
Anti-Ageing (Glycation)
Microbiome Balancing
Hydrating
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Skin Barrier Strengthening
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Anti-Bacterial
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Anti-Wrinkle
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Firming & Lifting
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Plumping
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Regenerating
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Scar-Repairing
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Brightening (Energising)
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Anti-Redness
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Antioxidant
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Anti-Inflammatory
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Photo-Protecting
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Cell Communication
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Anti-Pigmentation
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Injectable Effect
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Anti-Ageing (Glycation)
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Microbiome Balancing
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Hydrating
Active Ingredients
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EpigenActiv©
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Mimosa Tenuiflora Extract
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Peony Extract
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Centella Asiatica
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Complex of Matrikines
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Argireline
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Carcinine
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White Tea Leaf Extract
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Complex of Watercress Sprout Extract and Soy-based Pure Genistin
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Skin-Protective Sugars
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Wasabi Extract
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Grape Juice Extract Enriched with Viniferin
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Low Molecular Weight Hyaluronic Acid
EpigenActiv©
Mimosa Tenuiflora Extract
Peony Extract
Centella Asiatica
Complex of Matrikines
Argireline
Carcinine
White Tea Leaf Extract
Complex of Watercress Sprout Extract and Soy-based Pure Genistin
Skin-Protective Sugars
Wasabi Extract
Grape Juice Extract Enriched with Viniferin
Low Molecular Weight Hyaluronic Acid
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EpigenActiv©
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Mimosa Tenuiflora Extract
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Peony Extract
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Centella Asiatica
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Complex of Matrikines
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Argireline
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Carcinine
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White Tea Leaf Extract
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Complex of Watercress Sprout Extract and Soy-based Pure Genistin
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Skin-Protective Sugars
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Wasabi Extract
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Grape Juice Extract Enriched with Viniferin
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Low Molecular Weight Hyaluronic Acid
Epigenetics Science
Clinical Proofs
Spotlight
Epigenetics Science
Clinical Proofs
Clinical Proofs
Frequently Asked Questions
Where do I use this cream in routine?
Can I use this cream if I have oily skin?
Can I use this cream if I have dry skin?
Can I use this cream if I have combination skin?
Can I use this product if I have sensitive skin?
Can I use this product if I have eczema/psoriasis?
Can I use this product if I have rosacea?
Can this product be used pregnancy/breast feeding?
Is the packaging recyclable?
Why I love it
X Natalie K-F
Founder, Embassy of Beauty













