La Grande Creme
Benefits
Biologique Recherche La Grande Creme is an advanced anti-ageing cream formulated to reverse signs of ageing. It harnesses potent actives to promote cellular regeneration, repair DNA damage and leave skin brighter, firmer and protected.
EpigenActiv — an advanced pentapeptide that targets epidermal growth factor receptors and inhibits microRNAs that impede skin repair with age — accelerates cellular renewal and regeneration to promote a more youthful appearance while activating cellular detoxification.
Mimosa Tenuiflora Extract aids in stimulating tissue repair to regenerate new tissue, with antimicrobial and healing benefits that protect and repair the skin. Peony Extract works on deeper layers of the skin to prevent early adipocyte loss and migration, preserving facial volume, density and facial contours.
Peony Extract works on deeper layers of the skin to prevent early adipocyte loss and migration, preserving facial volume, density and facial contours.
Centella Asiatica, the Complex of Matrikines and a broad spectrum of antioxidants and peptides — including Argireline, Carcinine and Stabilised Vitamin C — work in concert to firm, relax expression lines, brighten and protect, producing a comprehensively rejuvenated and visibly younger-looking complexion.
Biologique Recherche La Grande Creme is an advanced anti-ageing cream formulated to reverse signs of ageing. It harnesses potent actives to promote cellular regeneration, repair DNA damage and leave skin brighter, firmer and protected.
EpigenActiv — an advanced pentapeptide that targets epidermal growth factor receptors and inhibits microRNAs that impede skin repair with age — accelerates cellular renewal and regeneration to promote a more youthful appearance while activating cellular detoxification.
Mimosa Tenuiflora Extract aids in stimulating tissue repair to regenerate new tissue, with antimicrobial and healing benefits that protect and repair the skin. Peony Extract works on deeper layers of the skin to prevent early adipocyte loss and migration, preserving facial volume, density and facial contours.
Peony Extract works on deeper layers of the skin to prevent early adipocyte loss and migration, preserving facial volume, density and facial contours.
Centella Asiatica, the Complex of Matrikines and a broad spectrum of antioxidants and peptides — including Argireline, Carcinine and Stabilised Vitamin C — work in concert to firm, relax expression lines, brighten and protect, producing a comprehensively rejuvenated and visibly younger-looking complexion.
Read less50 ml
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Is this for you?
For you if
- Damaged Barrier
- Wrinkles
- Loss of Firmness
- Loss of Volume
- Hyperpigmentation
- Acne Redness
- Dull Skin
- Pigmentation
- Disrupted Microbiome
- Dehydration
- Fine Lines
Suitable for
- Dehydrated Skin
- Balanced Skin
Not for you if
How to apply
Core Routine
- First Cleanse
- Second Cleanse
- Toner
- Hydrating Serum
- Targeted Serum
- Cream / Facial Oil
Period after opening
Extended Routine
- Eye Cleanse
- First Cleanse
- Second Cleanse
- Toner (Non-Exfoliating)
- Toner (Exfoliating)
- Mask
- Hydrating Serum
- Targeted Serum
- Eye Care
- Cream / Facial Oil
- SPF
Ingredients
Mimosa Tenuiflora ExtractSkin Barrier Strengthening · Anti-Bacterial · Anti-Wrinkle
The Mimosa Tenuiflora Extract aids in stimulating tissue repair to regenerate new tissue and its anti-microbial & healing benefits protect and repair the skin.EpigenActiv©Regenerating
EpigenActiv© is an advanced pentapeptide that works by targeting Epidermal Growth Factor (EGF) receptors crucial for skin regeneration and protein recycling. It inhibits microRNAs that impede skin repair processes with age, accelerating cellular renewal and regeneration to promote a youthful appearance. Additionally, EpigenActiv© activates the SKP1 gene, which aids in cellular detoxification, helping eliminate waste. This dual action enhances skin clarity, resilience, and overall health, contributing to a radiant complexion.Peony ExtractPlumping
Peony Extract works to prevent skin ageing by enhancing skin cell communication. It specifically works on deeper layers of the skin to prevent early adipocyte (fat cells) loss and migration, preserving facial volume, density and facial contours.Complex of MatrikinesSkin Barrier Strengthening · Anti-Wrinkle · Firming & Lifting
A Complex of Matrikines are peptides already naturally present in the skin; they are cellular messengers which are capable of sequencing events to spark and improve the healing process. As we age, these peptides diminish significantly in their number and their abilities; this Complex not only stimulates the synthesis of these peptides, but it also improves the environment in which they reside, empowering them. Therefore, this Complex protects the skin against photo-ageing and time-ageing as it reverses the chronological ageing process by reducing the depth and surface area of wrinkles, and increases skin firmness and elasticity.ArgirelineFirming & Lifting · Plumping · Injectable Effect
Argeriline also known as Acetyl Hexapeptide-8 is a neurotransmitter-inhibiting peptide, meaning it can minimise muscle contractions to provide injection-free wrinkle smoothing results. It can also support collagen in the skin, helping to persevere skin firmness.CarcinineSkin Barrier Strengthening · Anti-Wrinkle · Firming & Lifting
Glycation is a natural biological process in which sugars bind to proteins such as collagen and elastin, forming harmful molecules known as Advanced Glycation End Products (AGEs). Over time, these AGEs accumulate and cause the skin’s support structure to stiffen and weaken, leading to wrinkles, dullness, and loss of elasticity. Preventing or reducing glycation is therefore essential to maintaining smooth, firm, and resilient skin.
Carcinine is a synthetic peptide, rich in antioxidant and anti-glycation properties, it works by binding to sugars before they attach to proteins, effectively inhibiting AGE formation. It can also help neutralise existing AGEs, reducing their impact on collagen and elastin integrity. In addition, Carcinine’s antioxidant activity helps to protect skin cells from oxidative stress and support the natural repair of structural proteins. It's beneficial for mature skin to help maintain firmness, elasticity, and brightness; as it protects collagen and elastin from glycation damage and promotes their repair.Complex of Watercress Sprout Extract and Soy-based Pure GenistinAnti-Pigmentation
The Complex of Watercress Sprout Extract and Soy-based Pure Genistin targets dark spots by inhibiting melanin and lipofuscin (oxidized sebum) production. It also offers photo-protective properties, preventing premature ageing of skin cells.Skin-Protective SugarsMicrobiome Balancing · Antioxidant
Skin-Protective Sugars are obtained through a fermentation process. They support a healthy and balanced skin microbiome, enhancing the skin's defence mechanisms against environmental aggressors and pathogens that can cause skin irritation.Wasabi ExtractBrightening
Wasabi in skincare is valued for its brightening and tone-enhancing properties, helping to revitalise dull, uneven skin. Rich in bioactive compounds such as isothiocyanates, it supports improved microcirculation and helps reduce oxidative stress, both of which contribute to a more radiant complexion. By energising the skin and enhancing its natural glow, wasabi helps promote a brighter, fresher, and more luminous appearance with improved overall clarity.Grape Juice Extract Enriched with ViniferinSkin Barrier Strengthening · Anti-Wrinkle · Firming & Lifting
Viniferin is a polyphenol compound found in certain fungi that grow on grapes. It is known for its potent antioxidant properties which help protect skin cells from damage caused by free radicals and environmental stressors, thereby preventing premature ageing. In addition, it also helps to inhibit glycation, a process in which excess sugars bind to structural proteins such as collagen and elastin, causing them to stiffen and lose functionality. By reducing glycation and stimulating collagen production, Viniferin supports skin firmness, elasticity, and smoothness. This dual action diminishes wrinkles whilst enhancing skin firmness and overall plumpness.Low Molecular Weight Hyaluronic AcidPlumping · Hydrating
Low Molecular Weight Hyaluronic Acid (LMW-HA) is a smaller, more penetrative form of hyaluronic acid. Unlike high molecular weight forms that primarily hydrate the skin’s surface, LMW-HA has the ability to penetrate deeper into the epidermis, where it attracts and binds water to maintain optimal moisture levels from within. This deep hydration helps improve skin elasticity, firmness and smoothness, while reducing the appearance of fine lines. Additionally, it enhances overall suppleness, making the complexion look plumper and more resilient. It is ideal for dehydrated, dull or mature skin, and especially those in need of long-lasting hydration and improved texture.BeeswaxSkin Barrier Strengthening · Nourishing · Reduces Trans Epidermal Water Loss
Beeswax is a non-comedogenic (does not clog pores) natural wax that forms a strong, protective barrier on the skin. This shield helps defend against external stresses like wind, sun, and cold, allowing the skin to heal and rejuvenate. Beeswax also nourishes the skin, leaving it feeling soft, hydrated, and smooth.
View full ingredient list
Smell & Texture
Delivery & Returns
ROYAL MAIL TRACKED 48:
£5.00 (free for members on orders over £75)
Delivered within 2-3 working days.
NEXT WORKING DAY DELIVERY:
£8.00 (free for members on orders over £150)
Delivered the next working day if ordered before 1pm.
SATURDAY UK DELIVERY:
£18.00
Delivered on Saturday when ordered before 1pm on Friday.
*(For NI, Channel Islands & Scotland - due to the courier service in place, we cannot guarantee next day delivery to these areas, however we expect you will receive your delivery within 2-5 days).
RETURNS
Items returned by post can take up to 14 working days to process. Credit notes can be applied to your account within 5 working days. For refunds, we will reimburse you using your original payment method which can take up to 14 days.
GET THE SET
La Grande Creme + Le Grand Serum
The Benefits
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Skin Barrier Strengthening
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Anti-Bacterial
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Anti-Wrinkle
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Firming & Lifting
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Plumping
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Regenerating
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Scar-Repairing
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Anti-Redness
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Photo-Protecting
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Cell Communication
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Injectable Effect
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Anti-Ageing (Glycation)
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Brightening (Energising)
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Anti-Pigmentation
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Microbiome Balancing
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Antioxidant
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Hydrating
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Nourishing
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Reduces Trans Epidermal Water Loss
Skin Barrier Strengthening
Anti-Bacterial
Anti-Wrinkle
Firming & Lifting
Plumping
Regenerating
Scar-Repairing
Anti-Redness
Photo-Protecting
Cell Communication
Injectable Effect
Anti-Ageing (Glycation)
Brightening (Energising)
Anti-Pigmentation
Microbiome Balancing
Antioxidant
Hydrating
Nourishing
Reduces Trans Epidermal Water Loss
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-
+
Skin Barrier Strengthening
-
-
+
Anti-Bacterial
-
-
+
Anti-Wrinkle
-
-
+
Firming & Lifting
-
-
+
Plumping
-
-
+
Regenerating
-
-
+
Scar-Repairing
-
-
+
Anti-Redness
-
-
+
Photo-Protecting
-
-
+
Cell Communication
-
-
+
Injectable Effect
-
-
+
Anti-Ageing (Glycation)
-
-
+
Brightening (Energising)
-
-
+
Anti-Pigmentation
-
-
+
Microbiome Balancing
-
-
+
Antioxidant
-
-
+
Hydrating
-
-
+
Nourishing
-
-
+
Reduces Trans Epidermal Water Loss
Spotlight
Epigenetics Science
Clinical Proofs
Clinical Proofs
Frequently Asked Questions
Where do I use this cream in routine?
Can I use this cream if I have oily skin?
Can I use this cream if I have dry skin?
Can I use this cream if I have combination skin?
Can I use this product if I have sensitive skin?
Can I use this product if I have eczema/psoriasis?
Can I use this product if I have rosacea?
Can this product be used pregnancy/breast feeding?
Is the packaging recyclable?
Why I love it
X Natalie K-F
Founder, Embassy of Beauty








