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The Ultimate Regeneration Collection

(1)
The Ultimate Regeneration Collection
Biologique Recherche
(1)
Benefits
  • Cellular Anti-Ageing
  • Regenerating
  • Barrier-Strengthening
  • Anti-Wrinkle
  • Firming
  • Lifting
  • Plumping
  • Anti-Pigmentation
  • Scar-Repairing
  • Brightening
  • Microbiome Balancing
  • Antioxidant
  • Anti-Inflammatory
  • Anti-Redness
  • Hydrating
  • Anti-Bacterial
  • Anti-Acne
  • Mattifying
  • Complexion-Unifying
  • Purifying
  • Detoxifying
  • Clears Pores

Our most advanced and luxurious anti-ageing duo, designed to reverse the visible signs of exogenous ageing caused by pollution, UV, and stress.

Le Grand Serum delivers 27 potent actives in a single formula, targeting firmness, protection, and cellular vitality with precision. 

La Grande Creme takes regeneration further by stimulating cell renewal, repairing DNA, and firming the skin’s structural matrix.

Together, they rebuild the skin’s foundation, restoring density, resilience, and a visibly smoother, plumper, and more toned complexion.

Read more

Our most advanced and luxurious anti-ageing duo, designed to reverse the visible signs of exogenous ageing caused by pollution, UV, and stress.

Le Grand Serum delivers 27 potent actives in a single formula, targeting firmness, protection, and cellular vitality with precision. 

La Grande Creme takes regeneration further by stimulating cell renewal, repairing DNA, and firming the skin’s structural matrix.

Together, they rebuild the skin’s foundation, restoring density, resilience, and a visibly smoother, plumper, and more toned complexion.

Read less

Set of 2

£1,565 £1,486
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MORE INFO

La Grande Creme
Le Grand Serum
  • - + Who it is for
  • - + How to apply
  • - + Where in your routine
  • - + Ingredients
  • - + Smell & texture
  • - + Who it is for
  • - + How to apply
  • - + Where in your routine
  • - + Ingredients
  • - + Smell & texture
La Grande Creme Le Grand Serum
  • - + Who it is for
  • - + How to apply
  • - + Where in your routine
  • - + Ingredients
  • - + Smell & texture
  • - + Who it is for
  • - + How to apply
  • - + Where in your routine
  • - + Ingredients
  • - + Smell & texture
Who it is for

FOR YOU IF:

Nourishing
Loss of Firmness
Volume Loss
Wrinkles
Pigmented Skin
Dull Skin
Dry Skin

NOT FOR YOU IF:

Oily Skin
Active Acne
Sensitive Skin
Rosacea

Not sure? Consult an expert.

How to apply

Apply a hazelnut-sized amount of La Grande Crème over the face, neck and décolleté. Massage delicately with fingertips, working with upward and outward strokes until the product is fully absorbed.

Where in your routine
Content image
Ingredients

Water (Aqua), Octyldodecanol, Cetearyl Alcohol, Glyceryl Stearate, Butylene Glycol, Glycerin, Propanediol, Alcohol, Undecane, Butyrospermum Parkii (Shea) Butter, Propylene Glycol, Ceteareth-20, Pentaerythrityl Tetrastearate, Sorbitan Stearate, Cetyl Palmitate, Cocoglycerides, Alpha-Glucan Oligosaccharide, Cera Alba (Beeswax), Lactobacillus/Wasabia Japonica Root Ferment Extract, Lecithin, Camellia Sinensis Leaf Extract, Decarboxy Carnosine HCL, Triethanolamine, Pichia Anomala Extract, Paeonia Albiflora Root Extract, PVP, Mimosa Tenuiflora Bark Extract, Onopordum Acanthium Flower/Leaf/Stem Extract, Polyacrylate Crosspolymer-6, Hydrogenated Lecithin, Carbomer, Sodium Lactate, Tannic Acid, Phenethyl Alcohol, Polysorbate 20, Vitis Vinifera (Grape) Juice Extract, Carum Carvi (Caraway) Fruit Oil, Jasminum Grandiflorum (Flower) Flower Extract, Caprylyl Glycol, Sambucus Nigra Flower Extract, Terminalia Catappa Leaf Extract, Soy Isoflavones, Lepidium Sativum Sprout Extract, Mentha Piperita (Peppermint) Oil, Acetyl Hexapeptide-8, Sorbic Acid, Maltodextrin, Tocopherol, Palmitoyl Oligopeptide, Pentapeptide-48, Palmitoyl Tetrapeptide-7, Helianthus Annuus (Sunflower) Seed Oil, Tridecane, Methylpropanediol, Ethylhexylglycerin, Phenoxyethanol, Polysorbate 80, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylhydroxamic Acid, Disodium EDTA, Limonene.

*This product contains nut-derived ingredients and should be avoided by individuals with nut allergies.

Please note: The ingredients listed in this product are subject to change as the formulation is updated. We aim to update the INCI list as soon as possible, but we encourage you to read the ingredient list on the product itself to ensure it's suitable for your personal use.

Smell & texture

SMELLS LIKE:

It has a clean, and very minimal botanical scent.

TEXTURE:

A thick, waxy and smooth texture.

Who it is for

FOR YOU IF:

Oil for Oily Tendency Skin
Dry Skin
Pigmented Skin
Dull Skin
Wrinkles
Loss of Firmness
Volume Loss

NOT FOR YOU IF:

Active Acne
Sensitive Skin
Reactive Skin
Rosacea

Not sure? Consult an expert.

How to apply

Apply a few drops of Le Grand Serum to the entire face, neck and decollete in the morning and/or in the evening. Alternatively, a few drops can also be mixed into your cream.

Where in your routine
Content image
Ingredients

Water (Aqua), Propylene Glycol, Glycerin, Propanediol, Maltodextrin, Hydrolyzed Hazelnut Protein, Lactobacillus/Wasabia Japonica Root Ferment Extract, Pentylene Glycol, Myrtus Communis Leaf Extract, Allium Cepa (Onion) Bulb Extract, Commiphora Myrrha Resin Extract, Honey Extract (Mel Extract), Camellia Sinensis Leaf Extract, Hamamelis Virginiana (Witch Hazel) Bark/Leaf Extract, Centella Asiatica Extract, Hypericum Perforatum Flower/Leaf/Stem Extract, Punica Granatum Pericarp Extract, Haematococcus Pluvialis Extract, Hydrolyzed Soy Protein, Hydrolyzed Yeast Protein, Yeast Extract, Saccharomyces Cerevisiae Extract, Biosaccharide Gum-1, Acetyl Hexapeptide-8, Niacinamide, Sodium Hyaluronate, Lactic Acid, Sodium Lactate, Citric Acid, Allantoin, Serine, Royal Jelly Extract, Carum Carvi (Caraway) Seed Oil, Mentha Piperita (Peppermint) Oil, Acacia Senegal Gum, Xanthan Gum, Caramel, Sorbitol, Lecithin, 1,2-Hexanediol, Tea-Lactate, Urea, Phenylpropanol, Phenoxyethanol, Caprylyl Glycol, Sodium Benzoate, Potassium Sorbate, Limonene.

*This product contains nut-derived ingredients and should be avoided by individuals with nut allergies.

Please note: The ingredients listed in this product are subject to change as the formulation is updated. We aim to update the INCI list as soon as possible, but we encourage you to read the ingredient list on the product itself to ensure it's suitable for your personal use.

Smell & texture

SMELLS LIKE:

A neutral scent with hints of botanical notes.

TEXTURE:

Light, fluid, and easily absorbed.

The Benefits

  • - + Anti-Ageing (Epigenetics)
  • - + Regenerating
  • - + Skin Barrier Strengthening
  • - + Anti-Wrinkle
  • - + Firming & Lifting
  • - + Plumping
  • - + Anti-Pigmentation
  • - + Scar-Repairing
  • - + Brightening (Energising)
  • - + Microbiome Balancing
  • - + Antioxidant
  • - + Photo-Protecting
  • - + Cell Communication
  • - + Anti-Ageing (Glycation)
  • - + Anti-Inflammatory
  • - + Anti-Redness
  • - + Injectable Effect
  • - + Hydrating
  • - + Anti-Bacterial
  • - + Sebum Regulating (Mattifying)
  • - + Complexion-Unifying (Anti-Blotchiness)
  • - + Purifying
  • - + Detoxifying
  • - + Pore Decongesting
Anti-Ageing (Epigenetics)

The breakthrough in anti-ageing skincare leverages the power of epigenetic factors—molecules that influence gene expression without altering DNA sequences. These molecules act like responsive switches, turning certain genes on or off in response to environmental cues and lifestyle choices, thereby dynamically adapting the skin's behaviour to external factors. Recent innovations in anti-ageing products harness epigenetic science by incorporating active ingredients that target these factors directly. By promoting gene expressions that support collagen synthesis, cellular regeneration, and antioxidant defences, these formulas effectively combat skin ageing. They visibly reduce fine lines, wrinkles, and dark spots while enhancing skin texture, elasticity, and radiance. This advanced approach addresses not only visible signs but also the underlying causes of skin ageing for comprehensive rejuvenation.

Regenerating

Regenerating skincare actively stimulates the formation of new, healthier skin, working in alignment with the skin’s innate renewal processes. Central to this are growth factors—effectively encouraging the development of new skin tissue. Peptides complement this by acting as targeted messengers guiding the skin to rebuild with greater strength and structural integrity. Stem cell–derived actives further support this environment by delivering protective and regenerative signals that optimize cellular function and renewal. While these mechanisms are synonymous with advanced anti-ageing—improving firmness, elasticity and overall skin quality—they are equally valuable in addressing scarring, as they promote tissue repair, accelerate regeneration and help restore a smoother, more even skin surface.

Skin Barrier Strengthening

Strengthening your skin barrier involves replenishing the key elements in the top layer of your skin (stratum corneum), leading to a stronger and healthier barrier. These essential elements include lipids (ceramides, fatty acids, and cholesterol) and Natural Moisturizing Factors (amino acids, hyaluronic acid, etc.). Various factors, such as incorrect skincare use, seasonal changes, and aesthetic treatments, can damage your skin barrier. When this happens, your skin loses excess water through Trans Epidermal Water Loss (T.E.W.L) and becomes less capable of defending against environmental stressors, resulting in dryness, sensitivity, and irritation.

A healthy skin barrier is crucial for overall skin health as it helps prevent hydration loss, protects against environmental damage, and reduces the risk of skin conditions like eczema and acne. By strengthening your skin barrier, you ensure your skin remains well-hydrated, resilient, and protected.

Anti-Wrinkle

Anti-wrinkle skincare is focused on both preventing and visibly reducing the formation of lines by targeting the structural and dynamic causes of wrinkles within the skin. Fine lines and deeper wrinkles develop as collagen and elastin decline, cell turnover slows and repeated facial movements create creases that become etched over time. Advanced formulations address these mechanisms through a combination of elastin-stimulating actives, smoothing peptides that help relax the appearance of expression lines, and deeply hydrating ingredients that plump the skin from within. By reinforcing the skin’s architecture while softening surface contractions and improving elasticity, anti-wrinkle skincare delivers a visibly smoother complexion.

Firming & Lifting

Firming & Lifting skincare is designed to restore strength, structure, and definition to the skin, creating a visibly tighter, more sculpted appearance. As the skin loses collagen and elasticity over time, it can begin to soften and sag, losing its natural contours. Advanced formulations work to rebuild this support from within—boosting firmness while helping to visibly lift and redefine the skin. The result is a smoother, more toned complexion with enhanced bounce and resilience, where facial contours appear sharper and elevated.

Plumping

Plumping involves using active ingredients to boost the production of key structural components like collagen, the dermal-epidermal junction and glycosaminoglycans (GAGs), giving your skin more volume and density. Collagen provides structural support and firmness, while the dermal-epidermal junction, a thin connective layer, ensures smooth, wrinkle-free skin by facilitating cell communication. GAGs, like hyaluronic acid, keep your skin hydrated and plump from within. By stimulating these components, active ingredients help restore your skin's plumpness and radiance.

Anti-Pigmentation

Dealing with pigmentation means targeting melanin overproduction to reduce dark spots and prevent new ones. Melanin production can be triggered by UV exposure, pollution, hormonal changes (like during pregnancy), and inflammation (from acne or cuts). This excess pigment is then transferred to surrounding cells in epidermis called keratinocytes, which then moves to the skin's surface, causing visible dark spots.

To treat hyperpigmentation, a personalised and consistent approach is needed. Our anti-pigmentation products include lightening agents to block tyrosinase (the enzyme that creates melanin), antioxidants to fight free radicals, and ingredients to speed up skin cell turnover, removing pigmented cells. Using broad-spectrum sun protection is crucial to prevent new pigmentation during treatment.

Scar-Repairing

Anti-Scarring skincare targets the textured scars left by acne breakouts. These scars form due to inflammation disrupting collagen and elastin fibres leading to uneven healing and indented areas. Anti-Scarring actives harness growth factors and exfoliating actives to stimulate cell repair and regeneration, optimising the skin's healing process to reduce scar formation. They also effectively diminish older scars, improving overall skin texture and leaving you with a smoother complexion and significantly reduced scar visibility.

Brightening (Energising)

Brightening skincare involves using active ingredients to boost your blood circulation, detoxification and cellular energy. Improved blood circulation brings more essential nutrients and oxygen to your skin, while detoxification helps eliminate cell waste and impurities that can make your skin look dull. Certain active ingredients also enhance your skin's metabolism and regeneration. These combined actions restore your skin's vitality and radiant appearance, giving you a fresh, energised complexion.

Microbiome Balancing

Microbiome Balancing skincare focuses on supporting the skin’s ecosystem through a precise combination of prebiotics, probiotics, and postbiotics—each playing a distinct and complementary role. Prebiotics act as a targeted nutrient source, feeding and promoting the growth of beneficial microorganisms to maintain balance within the skin’s microbiome. Probiotics then introduce and reinforce these beneficial bacteria, helping to strengthen the skin’s natural defenses and reduce the presence of harmful strains. Postbiotics, the bioactive compounds produced through this process, enhance overall skin function by supporting barrier strength, improving hydration, and calming inflammation. Together, this synergistic approach stabilises the skin environment, resulting in a complexion that is clearer, more resilient, and visibly healthier.

Antioxidant

Antioxidant skincare is dedicated to protecting the skin against oxidative stress—one of the primary drivers of premature ageing and cellular damage—while preserving overall skin integrity and vitality. These formulations rely on potent molecules such as vitamin C, vitamin E, and polyphenols, which neutralize free radicals generated by UV exposure and environmental aggressors before they can compromise cellular structures like lipids, proteins, and DNA. Beyond defence, many antioxidants also support repair processes and enhance collagen stability, contributing to improved firmness, brightness and resilience. The result is skin that is not only shielded from ongoing damage but maintained in a healthier, more luminous state over time.

Photo-Protecting

Photo-protecting skincare at a cellular level focuses on defending the skin against the internal damage triggered by UV exposure, rather than simply blocking rays at the surface. Ultraviolet radiation generates free radicals and disrupts cellular DNA, accelerating collagen breakdown, inflammation, and premature ageing. Advanced formulations work by neutralising oxidative stress, supporting DNA repair mechanisms, and strengthening the skin’s natural defence systems to limit long-term damage. By preserving cellular integrity and maintaining healthy skin function, this approach helps prevent visible signs of photo-ageing—such as wrinkles, loss of firmness, and uneven tone.

Cell Communication

Cell-communicating ingredients support the skin by enhancing the dialogue between its cells, helping them function in a more intelligent and responsive way. Advanced actives such as growth factors, peptides and plant stem cells act as molecular messengers, signalling to skin cells and encouraging them to repair, regenerate and protect themselves against environmental stress and the visible effects of ageing.

When delivered topically in well-formulated skincare, these ingredients help stimulate essential processes such as collagen production, cellular renewal and barrier repair. The result is skin that appears stronger, smoother and more resilient over time. For these ingredients to perform optimally, they must also be bioavailable meaning the skin can readily recognise, absorb and utilise them. The closer an ingredient’s structure is to that of human skin cells, the more effectively it can interact with the skin’s natural biology, allowing it to deliver meaningful and visible results.

Anti-Ageing (Glycation)

Combat Glycation and maintain firm, plump, and youthful skin with anti-glycation actives. Glycation is a unique phenomenon where excess sugar molecules from your diet bind to essential proteins like collagen and elastin. This binding process can affect the structural proteins in your skin, like collagen and elastin, which are crucial for maintaining its firmness and elasticity. This results in wrinkles, loss of elasticity, and can even trigger excess pigment production, leading to dark marks and dullness.

Prevent and reverse the effects of glycation by adopting a low-sugar diet and incorporating targeted skincare with anti-glycation actives. These specialised ingredients help prevent sugar from binding to your skin's proteins and repair existing damage, preserving your skin's health and radiance.

Anti-Inflammatory

Anti-Inflammatory skincare soothes, heal, and balance your skin, the targeted actives are designed to reduce inflammation. Inflammation is your body's natural response to injury or irritation, but continuous inflammation can lead to troublesome skin conditions like acne, rosacea, or eczema. Our anti-inflammatory skincare solutions work to soothe and calm your skin, reducing redness, swelling, and discomfort to provide much-needed relief. By strengthening your skin's barrier, these products help protect against further irritation and damage. Additionally, the anti-inflammatory actives support your skin's natural healing processes, leading to a more balanced and resilient complexion.

Anti-Redness

Anti-Redness skincare is all about reducing and preventing facial or body redness, which can result from irritation, skin conditions, compromised barriers, and hormonal changes. A targeted approach with multiple strategies works best for tackling redness. Anti-Redness formulations include active ingredients that soothe and strengthen your skin barrier. Their anti-inflammatory and antioxidant properties calm inflammation and protect against environmental irritants. Additionally, these ingredients have vasoconstrictive properties, meaning they reduce blood vessel dilation to lessen redness. Together, these actions help achieve a more even-toned, balanced complexion that's less prone to redness flare-ups.

Injectable Effect

The ''Injectable-Like Effect'' involves using these neurotransmitter-inhibiting peptides to relax tiny facial muscles, smoothing out existing wrinkles. This process also stimulates the natural production of collagen and elastin, helping to prevent new wrinkles from forming.

Hydrating

Hydration is a fundamental part of healthy skincare, focusing on maintaining and restoring the skin’s water content. Well-hydrated skin appears plump, smooth and radiant, while dehydration can lead to dullness, tightness, fine lines and increased sensitivity.
Hydrating the skin can work through a fascinating mix of ingredients with different roles. Humectants like hyaluronic acid and glycerin act like water magnets, pulling water into the skin to instantly plump and smooth, while Natural Moisturizing Factors (NMFs)—such as urea, amino acids and sodium PCA—mimic the skin’s own hydration system, helping it hold onto water and stay balanced from within.
Adding humectants like hyaluronic acid to your routine will restore your skin's healthy glow, minimize fine lines, and provide a plumping effect.

Anti-Bacterial

Anti-bacterial action targets and inhibits the growth of bacteria on your skin's surface. Anti-bacterial ingredients work by disrupting essential bacterial processes like cell wall synthesis or protein production, reducing the risk of skin infections and inflammation. They are especially effective for treating acne by controlling the acne-causing bacteria known as Cutibacterium acnes (C. acnes). This anti-bacterial action helps diminish imperfections, prevent new breakouts, and reduce irritation, giving you clearer, healthier skin.

Sebum Regulating (Mattifying)

Sebum regulation involves normalising oil production in your sebaceous glands to reduce shine, oiliness and breakouts, restoring your skin's natural balance. Overactive sebaceous glands can be triggered by internal factors like genetics, hormonal changes and stress, as well as external factors such as using stripping or overly active skincare, climate, pollution and diet. Excessive sebum production can lead to enlarged pores, acne and an oily, shiny appearance. Effective sebum regulation means using skincare products that balance oil levels without over-drying your skin, helping you achieve a clearer, more matte complexion.

Complexion-Unifying (Anti-Blotchiness)

Evening skin tone is all about reducing blotchiness and achieving a more uniform complexion. Skincare products designed for this purpose use a blend of active ingredients, including soothing agents, anti-pigmentation compounds, antioxidants, and skin-restoring elements. These ingredients work together to diminish redness, inflammation, and pigment irregularities caused by inflammation, while also strengthening and protecting your skin against environmental irritants and future damage. This promotes healing and resilience, leaving your skin more balanced, radiant, and beautiful.

Purifying

Purifying skincare is designed to deeply cleanse and decongest the skin by targeting excess oil at its source—within the pores. Rather than simply removing surface shine, these formulations work to dissolve and dislodge sebum, debris, and impurities trapped inside the pore lining, helping to prevent congestion, blackheads, and breakouts. Actives such as exfoliating acids and oil-regulating ingredients penetrate into the pore to effectively “strip out” excess oil, restoring clarity and refining skin texture. By clearing buildup from within, purifying treatments leave the skin feeling exceptionally clean, balanced and visibly smoother.

Detoxifying

Detoxifying skincare focuses on clearing the skin of accumulated pollutants, toxins, and metabolic waste that can dull the complexion and disrupt healthy function. Daily exposure to environmental aggressors such as pollution and oxidative stress can overwhelm the skin, leading to congestion, imbalance, and premature ageing. Advanced detoxifying formulations work to neutralise these impurities, support the skin’s natural elimination processes, and reduce the buildup of harmful particles within pores and on the surface. By restoring clarity and balance, this approach leaves the skin feeling purified, refreshed and visibly brighter.

Pore Decongesting

Pore decongesting focuses on both clearing and minimising the appearance of enlarged pores. Enlarged pores often result from excess oil production and the build-up of impurities within the pore, which can stretch them over time, while ageing further contributes as reduced elasticity makes them more visible. Effective formulations work first to clear the pores—dissolving and removing trapped sebum, debris, and congestion—before regulating oil production and supporting collagen and elastin to improve skin firmness. By addressing both internal build-up and structural integrity, pores can return to a clearer, more refined, and less noticeable state.

  • - + Anti-Ageing (Epigenetics)
  • - + Regenerating
  • - + Skin Barrier Strengthening
  • - + Anti-Wrinkle
  • - + Firming & Lifting
  • - + Plumping
  • - + Anti-Pigmentation
  • - + Scar-Repairing
  • - + Brightening (Energising)
  • - + Microbiome Balancing
  • - + Antioxidant
  • - + Photo-Protecting
  • - + Cell Communication
  • - + Anti-Ageing (Glycation)
  • - + Anti-Inflammatory
  • - + Anti-Redness
  • - + Injectable Effect
  • - + Hydrating
  • - + Anti-Bacterial
  • - + Sebum Regulating (Mattifying)
  • - + Complexion-Unifying (Anti-Blotchiness)
  • - + Purifying
  • - + Detoxifying
  • - + Pore Decongesting
Biologique Recherche Ultimate Regeneration Collection - Cream & Oil
Biologique Recherche

The Ultimate Regeneration Collection

£1,565 £1,486

Our most advanced and luxurious anti-ageing duo, designed to reverse the visible signs of exogenous ageing caused by pollution, UV, and stress.

Le Grand Serum delivers 27 potent actives in a single formula, targeting firmness, protection, and cellular vitality with precision. 

La Grande Creme takes regeneration further by stimulating cell renewal, repairing DNA, and firming the skin’s structural matrix.

Together, they rebuild the skin’s foundation, restoring density, resilience, and a visibly smoother, plumper, and more toned complexion.

View product