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Le Grand Serum

LIQUID GOLD
Le Grand Serum
Biologique Recherche
Benefits
  • Cellular Anti-Ageing
  • Regenerating
  • Barrier-Strengthening
  • Anti-Wrinkle
  • Firming
  • Lifting
  • Plumping
  • Anti-Pigmentation
  • Scar-Repairing
  • Brightening
  • Microbiome Balancing
  • Mattifying
  • Complexion-Unifying
  • Purifying
  • Anti-Acne
  • Detoxifying
  • Clears Pores
  • Hydrating
  • Anti-Inflammatory
  • Antioxidant
  • Anti-Redness

Biologique Recherche Le Grand Serum is a powerful anti-ageing face oil. Its luxurious blend of 27 active ingredients slows cellular ageing, protects, firms and regenerates the skin, restoring radiance for a youthful complexion.

Telomeractiv — a breakthrough anti-ageing ingredient that protects telomeres, the protective caps at the ends of our chromosomes — helps maintain telomere length and the cells' capacity to divide and renew, producing a fundamental anti-ageing effect at the cellular level.

Yeast Extract supports a healthier microbial environment on the skin's surface and encourages gentle cellular turnover for a more refined and radiant complexion. Witch Hazel & St John's Wort Extract tone, firm and protect the skin with astringent and antioxidant plant actives.

Low Molecular Weight Hyaluronic Acid restores deep hydration and plumpness, while Myorelax Peptide, Beta-Glucan, Onion Myrrh & Myrtle Extract, White Tea Leaf Extract and Vitamin B3 (Niacinamide) collectively relax expression lines, soothe, brighten and strengthen the barrier, producing a measurably younger-looking, more luminous and comprehensively rejuvenated complexion.

Read more

Biologique Recherche Le Grand Serum is a powerful anti-ageing face oil. Its luxurious blend of 27 active ingredients slows cellular ageing, protects, firms and regenerates the skin, restoring radiance for a youthful complexion.

Telomeractiv — a breakthrough anti-ageing ingredient that protects telomeres, the protective caps at the ends of our chromosomes — helps maintain telomere length and the cells' capacity to divide and renew, producing a fundamental anti-ageing effect at the cellular level.

Yeast Extract supports a healthier microbial environment on the skin's surface and encourages gentle cellular turnover for a more refined and radiant complexion. Witch Hazel & St John's Wort Extract tone, firm and protect the skin with astringent and antioxidant plant actives.

Low Molecular Weight Hyaluronic Acid restores deep hydration and plumpness, while Myorelax Peptide, Beta-Glucan, Onion Myrrh & Myrtle Extract, White Tea Leaf Extract and Vitamin B3 (Niacinamide) collectively relax expression lines, soothe, brighten and strengthen the barrier, producing a measurably younger-looking, more luminous and comprehensively rejuvenated complexion.

Read less

30 ml

£662
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Get The Set
Biologique Recherche Ultimate Regeneration Collection - Cream & Oil
The Ultimate Regeneration Collection

La Grande Creme
Le Grand Serum

£1,565 £1,486

More Info

  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
Who it is for
Green tick
For you if

Oil for Oily Tendency Skin

Dry Skin

Pigmented Skin

Dull Skin

Wrinkles

Loss of Firmness

Volume Loss

How to Apply
Apply a few drops of Le Grand Sérum to the entire face, neck and décolleté in the morning and/or in the evening. Alternatively, a few drops can also be mixed into your cream.
Ingredients

Scroll down the page for a full breakdown of the active ingredients.

Water (Aqua), Propylene Glycol, Glycerin, Propanediol, Maltodextrin, Hydrolyzed Hazelnut Protein, Lactobacillus/Wasabia Japonica Root Ferment Extract, Pentylene Glycol, Myrtus Communis Leaf Extract, Allium Cepa (Onion) Bulb Extract, Commiphora Myrrha Resin Extract, Honey Extract (Mel Extract), Camellia Sinensis Leaf Extract, Hamamelis Virginiana (Witch Hazel) Bark/Leaf Extract, Centella Asiatica Extract, Hypericum Perforatum Flower/Leaf/Stem Extract, Punica Granatum Pericarp Extract, Haematococcus Pluvialis Extract, Hydrolyzed Soy Protein, Hydrolyzed Yeast Protein, Yeast Extract, Saccharomyces Cerevisiae Extract, Biosaccharide Gum-1, Acetyl Hexapeptide-8, Niacinamide, Sodium Hyaluronate, Lactic Acid, Sodium Lactate, Citric Acid, Allantoin, Serine, Royal Jelly Extract, Carum Carvi (Caraway) Seed Oil, Mentha Piperita (Peppermint) Oil, Acacia Senegal Gum, Xanthan Gum, Caramel, Sorbitol, Lecithin, 1,2-Hexanediol, Tea-Lactate, Urea, Phenylpropanol, Phenoxyethanol, Caprylyl Glycol, Sodium Benzoate, Potassium Sorbate, Limonene.

*This product contains nut-derived ingredients and should be avoided by individuals with nut allergies.


Please note: The ingredients listed in this product are subject to change as the formulation is updated. We aim to update the INCI list as soon as possible, but we encourage you to read the ingredient list on the product itself to ensure it's suitable for your personal use.

Smell & Texture

Smells Like: A neutral scent with hints of botanical notes.

Texture: Light, fluid, and easily absorbed.

About the Brand
Brand logo
Founded in Paris in the late 1970s by biologist Yvan Allouche and physiotherapist Josette Allouche, Biologique Recherche began as a laboratory for bespoke, high-performance formulas for elite skin professionals. Their medical-grade precision and artisanal formulation, paired with consummate savoir-faire, underpin their reputation for outstanding, clinically proven results.

Biologique Recherche treats skin according to its Skin Instant©, the skin’s precise, evolving state. Each formula is loaded with active ingredients in exceptional concentrations, then prescribed to address those real-time needs. This precision approach corrects imbalances, restores function, and delivers visible, lasting transformation.

Cold-processed actives are the core of Biologique Recherche. Formulated at 18–25°C, this method avoids the 70°C heat of standard processing that breaks down actives. Botanical, marine, and biotechnological extracts stay intact for higher absorption, stronger repair, and better tolerance. Antioxidants, peptides, and enzymes remain stable, ensuring consistent, visible results.

The Benefits

  • - + Anti-Ageing (Epigenetics)
  • - + Regenerating
  • - + Skin Barrier Strengthening
  • - + Anti-Wrinkle
  • - + Firming & Lifting
  • - + Plumping
  • - + Anti-Pigmentation
  • - + Scar-Repairing
  • - + Brightening (Energising)
  • - + Microbiome Balancing
  • - + Sebum Regulating (Mattifying)
  • - + Complexion-Unifying (Anti-Blotchiness)
  • - + Purifying
  • - + Detoxifying
  • - + Pore Decongesting
  • - + Hydrating
  • - + Injectable Effect
  • - + Anti-Inflammatory
  • - + Antioxidant
  • - + Anti-Redness
Anti-Ageing (Epigenetics)

The breakthrough in anti-ageing skincare leverages the power of epigenetic factors—molecules that influence gene expression without altering DNA sequences. These molecules act like responsive switches, turning certain genes on or off in response to environmental cues and lifestyle choices, thereby dynamically adapting the skin's behaviour to external factors. Recent innovations in anti-ageing products harness epigenetic science by incorporating active ingredients that target these factors directly. By promoting gene expressions that support collagen synthesis, cellular regeneration, and antioxidant defences, these formulas effectively combat skin ageing. They visibly reduce fine lines, wrinkles, and dark spots while enhancing skin texture, elasticity, and radiance. This advanced approach addresses not only visible signs but also the underlying causes of skin ageing for comprehensive rejuvenation.

Regenerating

Regenerating skincare actively stimulates the formation of new, healthier skin, working in alignment with the skin’s innate renewal processes. Central to this are growth factors—effectively encouraging the development of new skin tissue. Peptides complement this by acting as targeted messengers guiding the skin to rebuild with greater strength and structural integrity. Stem cell–derived actives further support this environment by delivering protective and regenerative signals that optimize cellular function and renewal. While these mechanisms are synonymous with advanced anti-ageing—improving firmness, elasticity and overall skin quality—they are equally valuable in addressing scarring, as they promote tissue repair, accelerate regeneration and help restore a smoother, more even skin surface.

Skin Barrier Strengthening

Strengthening your skin barrier involves replenishing the key elements in the top layer of your skin (stratum corneum), leading to a stronger and healthier barrier. These essential elements include lipids (ceramides, fatty acids, and cholesterol) and Natural Moisturizing Factors (amino acids, hyaluronic acid, etc.). Various factors, such as incorrect skincare use, seasonal changes, and aesthetic treatments, can damage your skin barrier. When this happens, your skin loses excess water through Trans Epidermal Water Loss (T.E.W.L) and becomes less capable of defending against environmental stressors, resulting in dryness, sensitivity, and irritation.

A healthy skin barrier is crucial for overall skin health as it helps prevent hydration loss, protects against environmental damage, and reduces the risk of skin conditions like eczema and acne. By strengthening your skin barrier, you ensure your skin remains well-hydrated, resilient, and protected.

Anti-Wrinkle

Anti-wrinkle skincare is focused on both preventing and visibly reducing the formation of lines by targeting the structural and dynamic causes of wrinkles within the skin. Fine lines and deeper wrinkles develop as collagen and elastin decline, cell turnover slows and repeated facial movements create creases that become etched over time. Advanced formulations address these mechanisms through a combination of elastin-stimulating actives, smoothing peptides that help relax the appearance of expression lines, and deeply hydrating ingredients that plump the skin from within. By reinforcing the skin’s architecture while softening surface contractions and improving elasticity, anti-wrinkle skincare delivers a visibly smoother complexion.

Firming & Lifting

Firming & Lifting skincare is designed to restore strength, structure, and definition to the skin, creating a visibly tighter, more sculpted appearance. As the skin loses collagen and elasticity over time, it can begin to soften and sag, losing its natural contours. Advanced formulations work to rebuild this support from within—boosting firmness while helping to visibly lift and redefine the skin. The result is a smoother, more toned complexion with enhanced bounce and resilience, where facial contours appear sharper and elevated.

Plumping

Plumping involves using active ingredients to boost the production of key structural components like collagen, the dermal-epidermal junction and glycosaminoglycans (GAGs), giving your skin more volume and density. Collagen provides structural support and firmness, while the dermal-epidermal junction, a thin connective layer, ensures smooth, wrinkle-free skin by facilitating cell communication. GAGs, like hyaluronic acid, keep your skin hydrated and plump from within. By stimulating these components, active ingredients help restore your skin's plumpness and radiance.

Anti-Pigmentation

Dealing with pigmentation means targeting melanin overproduction to reduce dark spots and prevent new ones. Melanin production can be triggered by UV exposure, pollution, hormonal changes (like during pregnancy), and inflammation (from acne or cuts). This excess pigment is then transferred to surrounding cells in epidermis called keratinocytes, which then moves to the skin's surface, causing visible dark spots.

To treat hyperpigmentation, a personalised and consistent approach is needed. Our anti-pigmentation products include lightening agents to block tyrosinase (the enzyme that creates melanin), antioxidants to fight free radicals, and ingredients to speed up skin cell turnover, removing pigmented cells. Using broad-spectrum sun protection is crucial to prevent new pigmentation during treatment.

Scar-Repairing

Anti-Scarring skincare targets the textured scars left by acne breakouts. These scars form due to inflammation disrupting collagen and elastin fibres leading to uneven healing and indented areas. Anti-Scarring actives harness growth factors and exfoliating actives to stimulate cell repair and regeneration, optimising the skin's healing process to reduce scar formation. They also effectively diminish older scars, improving overall skin texture and leaving you with a smoother complexion and significantly reduced scar visibility.

Brightening (Energising)

Brightening skincare involves using active ingredients to boost your blood circulation, detoxification and cellular energy. Improved blood circulation brings more essential nutrients and oxygen to your skin, while detoxification helps eliminate cell waste and impurities that can make your skin look dull. Certain active ingredients also enhance your skin's metabolism and regeneration. These combined actions restore your skin's vitality and radiant appearance, giving you a fresh, energised complexion.

Microbiome Balancing

Microbiome Balancing skincare focuses on supporting the skin’s ecosystem through a precise combination of prebiotics, probiotics, and postbiotics—each playing a distinct and complementary role. Prebiotics act as a targeted nutrient source, feeding and promoting the growth of beneficial microorganisms to maintain balance within the skin’s microbiome. Probiotics then introduce and reinforce these beneficial bacteria, helping to strengthen the skin’s natural defenses and reduce the presence of harmful strains. Postbiotics, the bioactive compounds produced through this process, enhance overall skin function by supporting barrier strength, improving hydration, and calming inflammation. Together, this synergistic approach stabilises the skin environment, resulting in a complexion that is clearer, more resilient, and visibly healthier.

Sebum Regulating (Mattifying)

Sebum regulation involves normalising oil production in your sebaceous glands to reduce shine, oiliness and breakouts, restoring your skin's natural balance. Overactive sebaceous glands can be triggered by internal factors like genetics, hormonal changes and stress, as well as external factors such as using stripping or overly active skincare, climate, pollution and diet. Excessive sebum production can lead to enlarged pores, acne and an oily, shiny appearance. Effective sebum regulation means using skincare products that balance oil levels without over-drying your skin, helping you achieve a clearer, more matte complexion.

Complexion-Unifying (Anti-Blotchiness)

Evening skin tone is all about reducing blotchiness and achieving a more uniform complexion. Skincare products designed for this purpose use a blend of active ingredients, including soothing agents, anti-pigmentation compounds, antioxidants, and skin-restoring elements. These ingredients work together to diminish redness, inflammation, and pigment irregularities caused by inflammation, while also strengthening and protecting your skin against environmental irritants and future damage. This promotes healing and resilience, leaving your skin more balanced, radiant, and beautiful.

Purifying

Purifying skincare is designed to deeply cleanse and decongest the skin by targeting excess oil at its source—within the pores. Rather than simply removing surface shine, these formulations work to dissolve and dislodge sebum, debris, and impurities trapped inside the pore lining, helping to prevent congestion, blackheads, and breakouts. Actives such as exfoliating acids and oil-regulating ingredients penetrate into the pore to effectively “strip out” excess oil, restoring clarity and refining skin texture. By clearing buildup from within, purifying treatments leave the skin feeling exceptionally clean, balanced and visibly smoother.

Detoxifying

Detoxifying skincare focuses on clearing the skin of accumulated pollutants, toxins, and metabolic waste that can dull the complexion and disrupt healthy function. Daily exposure to environmental aggressors such as pollution and oxidative stress can overwhelm the skin, leading to congestion, imbalance, and premature ageing. Advanced detoxifying formulations work to neutralise these impurities, support the skin’s natural elimination processes, and reduce the buildup of harmful particles within pores and on the surface. By restoring clarity and balance, this approach leaves the skin feeling purified, refreshed and visibly brighter.

Pore Decongesting

Pore decongesting focuses on both clearing and minimising the appearance of enlarged pores. Enlarged pores often result from excess oil production and the build-up of impurities within the pore, which can stretch them over time, while ageing further contributes as reduced elasticity makes them more visible. Effective formulations work first to clear the pores—dissolving and removing trapped sebum, debris, and congestion—before regulating oil production and supporting collagen and elastin to improve skin firmness. By addressing both internal build-up and structural integrity, pores can return to a clearer, more refined, and less noticeable state.

Hydrating

Hydration is a fundamental part of healthy skincare, focusing on maintaining and restoring the skin’s water content. Well-hydrated skin appears plump, smooth and radiant, while dehydration can lead to dullness, tightness, fine lines and increased sensitivity.
Hydrating the skin can work through a fascinating mix of ingredients with different roles. Humectants like hyaluronic acid and glycerin act like water magnets, pulling water into the skin to instantly plump and smooth, while Natural Moisturizing Factors (NMFs)—such as urea, amino acids and sodium PCA—mimic the skin’s own hydration system, helping it hold onto water and stay balanced from within.
Adding humectants like hyaluronic acid to your routine will restore your skin's healthy glow, minimize fine lines, and provide a plumping effect.

Injectable Effect

The ''Injectable-Like Effect'' involves using these neurotransmitter-inhibiting peptides to relax tiny facial muscles, smoothing out existing wrinkles. This process also stimulates the natural production of collagen and elastin, helping to prevent new wrinkles from forming.

Anti-Inflammatory

Anti-Inflammatory skincare soothes, heal, and balance your skin, the targeted actives are designed to reduce inflammation. Inflammation is your body's natural response to injury or irritation, but continuous inflammation can lead to troublesome skin conditions like acne, rosacea, or eczema. Our anti-inflammatory skincare solutions work to soothe and calm your skin, reducing redness, swelling, and discomfort to provide much-needed relief. By strengthening your skin's barrier, these products help protect against further irritation and damage. Additionally, the anti-inflammatory actives support your skin's natural healing processes, leading to a more balanced and resilient complexion.

Antioxidant

Antioxidant skincare is dedicated to protecting the skin against oxidative stress—one of the primary drivers of premature ageing and cellular damage—while preserving overall skin integrity and vitality. These formulations rely on potent molecules such as vitamin C, vitamin E, and polyphenols, which neutralize free radicals generated by UV exposure and environmental aggressors before they can compromise cellular structures like lipids, proteins, and DNA. Beyond defence, many antioxidants also support repair processes and enhance collagen stability, contributing to improved firmness, brightness and resilience. The result is skin that is not only shielded from ongoing damage but maintained in a healthier, more luminous state over time.

Anti-Redness

Anti-Redness skincare is all about reducing and preventing facial or body redness, which can result from irritation, skin conditions, compromised barriers, and hormonal changes. A targeted approach with multiple strategies works best for tackling redness. Anti-Redness formulations include active ingredients that soothe and strengthen your skin barrier. Their anti-inflammatory and antioxidant properties calm inflammation and protect against environmental irritants. Additionally, these ingredients have vasoconstrictive properties, meaning they reduce blood vessel dilation to lessen redness. Together, these actions help achieve a more even-toned, balanced complexion that's less prone to redness flare-ups.

  • - + Anti-Ageing (Epigenetics)
  • - + Regenerating
  • - + Skin Barrier Strengthening
  • - + Anti-Wrinkle
  • - + Firming & Lifting
  • - + Plumping
  • - + Anti-Pigmentation
  • - + Scar-Repairing
  • - + Brightening (Energising)
  • - + Microbiome Balancing
  • - + Sebum Regulating (Mattifying)
  • - + Complexion-Unifying (Anti-Blotchiness)
  • - + Purifying
  • - + Detoxifying
  • - + Pore Decongesting
  • - + Hydrating
  • - + Injectable Effect
  • - + Anti-Inflammatory
  • - + Antioxidant
  • - + Anti-Redness

Active Ingredients

  • - + TÈlomeractiv©
  • - + Yeast Extract
  • - + Witch Hazel & St John's Wort Extract
  • - + Low Molecular Weight Hyaluronic Acid
  • - + Myorelax Peptide
  • - + Beta-Glucan
  • - + Onion, Myrrh & Myrtle Extract
  • - + White Tea Leaf Extract
  • - + Vitamin B3 (Niacinamide)
TÈlomeractiv©

TÈlomeractiv© is a breakthrough anti-ageing ingredient that protects telomeres, which are the protective caps at the ends of our chromosomes. These caps are crucial for maintaining healthy cell division. Every time cells divide, telomeres get shorter, which leads to cell ageing and eventual senescence (when cells stop dividing and functioning properly). TÈlomeractiv© helps maintain telomere length by providing important amino acids, peptides, and proteins needed for cell repair and activating telomerase, the enzyme that extends telomeres. Its antioxidant properties also reduce free radical damage, a major cause of telomere shortening. By supporting overall cell health, TÈlomeractiv© helps delay the signs of premature skin ageing.

Yeast Extract

Yeast extract is a bio-fermented active that helps rebalance the skin’s microbiome while regulating excess sebum and reducing congestion or dullness. By supporting a healthier microbial environment, it limits the growth of unwanted bacteria on the skin’s surface, helping to purify and refine texture without stripping or irritation. Its enzymatic action also encourages gentle cellular turnover, which helps lift away built-up dead skin cells and improves clarity, contributing to a brighter and more even complexion. Furthermore, yeast helps to reinforce barrier function so the skin remains more stable, resilient, and less reactive over time. This makes yeast extract especially effective for skin that is unbalanced, oily-tendency, stressed by urban pollution, or in need of both soothing repair and a clearer, healthier surface environment.

Witch Hazel & St John's Wort Extract

Witch Hazel & St. John’s Wort Extract are rich in tannins and flavonoids, delivering powerful astringent benefits that help tighten tissue, refine pores, and smooth the skin’s surface. They are especially effective for regulating excess sebum while also soothing and calming damaged or irritated skin. While St. John’s Wort naturally contains hypericin, a compound with photosensitising potential, in cosmetic formulations it is carefully refined and used at safe levels, making it suitable for daily use.

Low Molecular Weight Hyaluronic Acid

Low Molecular Weight Hyaluronic Acid (LMW-HA) is a smaller, more penetrative form of hyaluronic acid. Unlike high molecular weight forms that primarily hydrate the skin’s surface, LMW-HA has the ability to penetrate deeper into the epidermis, where it attracts and binds water to maintain optimal moisture levels from within. This deep hydration helps improve skin elasticity, firmness and smoothness, while reducing the appearance of fine lines and dehydration-induced wrinkles. Additionally, it enhances overall suppleness, making the complexion look plumper and more resilient. It is ideal for dehydrated, dull or mature skin, and especially those in need of long-lasting hydration and improved texture.

Myorelax Peptide

The Myorelax Peptide is a type of a small peptide that effectively relaxes muscle tension and inhibits micro-contractions, offering a gentle and non-invasive alternative anti-wrinkle injectables. This action reduces the depth and length of expression lines and wrinkles, providing a filling and smoothing effect.

Beta-Glucan

Beta-glucan, derived from yeast, is a chain of sugar molecule known for its humectant (hydrating), collagen-boosting, and anti-inflammatory properties. It strengthens the skin barrier, supports a balanced microbiome, and enhances resilience against environmental aggressors. Beta-glucan deeply hydrates the skin, diminishes wrinkles, and provides a soothing effect, making a great multi-benefit ingredient for all skin types.

Onion, Myrrh & Myrtle Extract

Unique to Biologique Recherche, the "Complex of Onion, Myrrh & Myrtle" has incredible astringent (tightening), purifying, antioxidant and soothing properties; which is very effective for an oilier complexion combatting sebum-regulation, acne or congestion.

White Tea Leaf Extract

Extracted from Camelia Sinensis buds, White Tea Leaf Extract is rich in antioxidants like catechins and polyphenols, protecting the skin from environmental damage and premature cellular ageing. Its anti-inflammatory properties soothe irritation and reduce redness, whilst promoting collagen production for enhanced firmness and elasticity.

Vitamin B3 (Niacinamide)

Vitamin B3 also known as Niacinamide, is versatile and highly effective ingredient with many benefits. It helps to strengthen skin barrier function and increase water retention by increasing natural ceramide production. It's anti-inflammatory and sebum regulating properties soothe, repair and balance irritated, weakened and acne prone skins. Niacinamide is also a potent antioxidant with protective and brightening properties helping to restore skin's natural glow.

  • - + TÈlomeractiv©
  • - + Yeast Extract
  • - + Witch Hazel & St John's Wort Extract
  • - + Low Molecular Weight Hyaluronic Acid
  • - + Myorelax Peptide
  • - + Beta-Glucan
  • - + Onion, Myrrh & Myrtle Extract
  • - + White Tea Leaf Extract
  • - + Vitamin B3 (Niacinamide)
Epigenetics Science

Epigenetics is an exciting area of science that looks at how our environment—things like UV exposure, pollution, and even our daily lifestyle choices—can influence the way our genes behave, without altering the DNA itself. These external factors can speed up skin ageing, cause pigmentation, and increase sensitivity, as they subtly modify how our skin cells function. Environmental influences don’t just affect the way we feel; they also impact our skin, often resulting in visible signs of ageing, uneven tone, and reduced resilience.

But there’s good news—understanding these changes opens up new possibilities for smarter, more targeted skincare. Epigenetic skincare focuses on ingredients and formulations that help counteract the changes caused by these external factors. By targeting the pathways that influence gene expression, epigenetic skincare works to optimise how your skin cells perform, supporting healthier, more youthful-looking skin. Key ingredients like peptides, antioxidants, and botanical extracts are used to repair damage, boost cell regeneration, and enhance the skin’s natural defences against environmental stressors, helping your skin bounce back stronger and more radiant. Using epigenetic skincare feels like giving your skin the extra support it needs to thrive in today’s world. With regular use, you’ll likely notice improvements in skin texture, tone, and overall resilience. It’s a thoughtful approach that works with your skin, not against it, helping you achieve a radiant, healthy complexion that stands up to everyday challenges.

Epigenetic skincare is more than just a trend—it’s a personalised approach to nurturing your skin at a deeper level. By choosing products that target gene expression, you’re investing in your skin’s long-term health and beauty. Embrace this innovative path to skincare, and enjoy the benefits of smoother, firmer, and more resilient skin that reflects your best, most radiant self.

Clinical Proofs

USAGE TEST:
Test carried out on 20 women, from 49 to 65 years old, presenting crow's feet wrinkles and fine lines, for 2
months with product application in the morning and evening.
Test carried out on 22 women, 45 to 60 years old, subject to skin ageing, for 28 days.
By neutralizing the DPPH free radical, Le Grand Sérum helps fight against oxidative stress by
stimulating the skin's antioxidant defences.
Reduces wrinkle depth by 7.9%
86% of women found that their skin was regenerated
91% of women found that their skin was toned
86% of women found that their skin was firmer
95% of women found that their skin was moisturised
91% of women found that their skin was smoother

* The above information has been supplied to the Embassy of Beauty by the brand manufacturer. Embassy of Beauty takes no responsibility for these claimed studies and or results.

Spotlight

Epigenetics Science

Epigenetics is an exciting area of science that looks at how our environment—things like UV exposure, pollution, and even our daily lifestyle choices—can influence the way our genes behave, without altering the DNA itself. These external factors can speed up skin ageing, cause pigmentation, and increase sensitivity, as they subtly modify how our skin cells function. Environmental influences don’t just affect the way we feel; they also impact our skin, often resulting in visible signs of ageing, uneven tone, and reduced resilience.

But there’s good news—understanding these changes opens up new possibilities for smarter, more targeted skincare. Epigenetic skincare focuses on ingredients and formulations that help counteract the changes caused by these external factors. By targeting the pathways that influence gene expression, epigenetic skincare works to optimise how your skin cells perform, supporting healthier, more youthful-looking skin. Key ingredients like peptides, antioxidants, and botanical extracts are used to repair damage, boost cell regeneration, and enhance the skin’s natural defences against environmental stressors, helping your skin bounce back stronger and more radiant. Using epigenetic skincare feels like giving your skin the extra support it needs to thrive in today’s world. With regular use, you’ll likely notice improvements in skin texture, tone, and overall resilience. It’s a thoughtful approach that works with your skin, not against it, helping you achieve a radiant, healthy complexion that stands up to everyday challenges.

Epigenetic skincare is more than just a trend—it’s a personalised approach to nurturing your skin at a deeper level. By choosing products that target gene expression, you’re investing in your skin’s long-term health and beauty. Embrace this innovative path to skincare, and enjoy the benefits of smoother, firmer, and more resilient skin that reflects your best, most radiant self.

Clinical Proofs

Clinical Proofs

USAGE TEST:
Test carried out on 20 women, from 49 to 65 years old, presenting crow's feet wrinkles and fine lines, for 2
months with product application in the morning and evening.
Test carried out on 22 women, 45 to 60 years old, subject to skin ageing, for 28 days.
By neutralizing the DPPH free radical, Le Grand Sérum helps fight against oxidative stress by
stimulating the skin's antioxidant defences.
Reduces wrinkle depth by 7.9%
86% of women found that their skin was regenerated
91% of women found that their skin was toned
86% of women found that their skin was firmer
95% of women found that their skin was moisturised
91% of women found that their skin was smoother

* The above information has been supplied to the Embassy of Beauty by the brand manufacturer. Embassy of Beauty takes no responsibility for these claimed studies and or results.

Why I love it

  • "The efficacy of Biologique Recherche relies not only on its science-driven approach to balancing and curing the skin, but on its prescriptive and tailored nature."

    X Natalie K-F

    Founder, Embassy of Beauty

  • Biologique Recherche Le Grand Sérum - tackles all facets of ageing and is the ultimate in illuminating, hydrating and rejuvenating the skin.
    Biologique Recherche

    Le Grand Serum

    £662

    Biologique Recherche Le Grand Serum is a powerful anti-ageing face oil. Its luxurious blend of 27 active ingredients slows cellular ageing, protects, firms and regenerates the skin, restoring radiance for a youthful complexion.

    Telomeractiv — a breakthrough anti-ageing ingredient that protects telomeres, the protective caps at the ends of our chromosomes — helps maintain telomere length and the cells' capacity to divide and renew, producing a fundamental anti-ageing effect at the cellular level.

    Yeast Extract supports a healthier microbial environment on the skin's surface and encourages gentle cellular turnover for a more refined and radiant complexion. Witch Hazel & St John's Wort Extract tone, firm and protect the skin with astringent and antioxidant plant actives.

    Low Molecular Weight Hyaluronic Acid restores deep hydration and plumpness, while Myorelax Peptide, Beta-Glucan, Onion Myrrh & Myrtle Extract, White Tea Leaf Extract and Vitamin B3 (Niacinamide) collectively relax expression lines, soothe, brighten and strengthen the barrier, producing a measurably younger-looking, more luminous and comprehensively rejuvenated complexion.

    View product