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Creme Grand Millesime

(6)
ILLUMINATING BRILLIANCE
Creme Grand Millesime
Biologique Recherche
(6)
Benefits
  • Nourishing
  • Brightening
  • Plumping
  • Anti-Ageing
  • Hydrating
  • Anti-Wrinkle
  • Soothing
  • Anti-Pigmentation
  • Antioxidant
  • Regenerating

The Biologique Recherche Creme Grand Millesime is a brightening and illuminating cream that revitalises, regenerates and hydrates the skin. It enhances the complexion and helps prevent signs of ageing.

Read more

The Biologique Recherche Creme Grand Millesime is a brightening and illuminating cream that revitalises, regenerates and hydrates the skin. It enhances the complexion and helps prevent signs of ageing.

Read less

50 ml

£211
MyEB
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Free Standard Delivery
(£75)
Free Next Day Delivery
(£150)
Free Samples
(£200)
Spend £75 more for Free Standard Delivery

More Info

  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
  • - + Who it is for
  • - + How to Apply
  • - + Ingredients
  • - + Smell & Texture
  • - + About the Brand
Who it is for
Green tick
For you if

Dull Skin

Dry Skin

Wrinkles

Volume Loss

Antioxidant Support

Red Cross
Not For you if
How to Apply
Apply a hazelnut-sized amount of Crème Grand Millésime over the face, neck and décolleté. Massage delicately with fingertips, working with upward and outward strokes until the product is fully absorbed.
Ingredients

Scroll down the page for a full breakdown of the active ingredients.

Water (Aqua), Caprylic/Capric Triglyceride, Coco-Caprylate/Caprate, Propylene Glycol, Glycerin, Pentaerythrityl Distearate, Cetyl Alcohol, Xylitylglucoside, 1,2-Hexanediol, Butyrospermum Parkii (Shea) Butter, Jojoba Esters, Cucumis Sativus (Cucumber) Fruit Extract, Helianthus Annuus (Sunflower) Seed Wax, Medicago Sativa (Alfalfa) Extract, Hydrolyzed Silk, Myrtus Communis Leaf Extract, Allium Cepa (Onion) Bulb Extract, Centella Asiatica Extract, Commiphora Myrrha Resin Extract, Hamamelis Virginiana (Witch Hazel) Bark/Leaf Extract, Hypericum Perforatum Flower/Leaf/Stem Extract, Sophora Japonica Flower Extract, Anhydroxylitol, Ascorbyl Glucoside, Xylitol, Sodium Hyaluronate, Glyceryl Stearates, Caramel, Tocopherol, Sodium Stearoyl Glutamate, Stearyl Alcohol, Polyacrylate Crosspolymer-6, Propanediol, Polyglycerin-3, Caprylyl Glycol, Sodium Hydroxide, Potassium Sorbate, Sodium Benzoate


Please note: The ingredients listed in this product are subject to change as the formulation is updated. We aim to update the INCI list as soon as possible, but we encourage you to read the ingredient list on the product itself to ensure it's suitable for your personal use.

Smell & Texture

Smell: It has a clean, subtle, slightly botanical scent

Texture: A smooth, pearly creamy texture

About the Brand
Brand logo
Founded in Paris in the late 1970s by biologist Yvan Allouche and physiotherapist Josette Allouche, Biologique Recherche began as a laboratory for bespoke, high-performance formulas for elite skin professionals. Their medical-grade precision and artisanal formulation, paired with consummate savoir-faire, underpin their reputation for outstanding, clinically proven results.

Biologique Recherche treats skin according to its Skin Instant©, the skin’s precise, evolving state. Each formula is loaded with active ingredients in exceptional concentrations, then prescribed to address those real-time needs. This precision approach corrects imbalances, restores function, and delivers visible, lasting transformation.

Cold-processed actives are the core of Biologique Recherche. Formulated at 18–25°C, this method avoids the 70°C heat of standard processing that breaks down actives. Botanical, marine, and biotechnological extracts stay intact for higher absorption, stronger repair, and better tolerance. Antioxidants, peptides, and enzymes remain stable, ensuring consistent, visible results.

The Benefits

  • - + Nourishing
  • - + Brightening (Energising)
  • - + Plumping
  • - + Anti-Ageing (Glycation)
  • - + Anti-Wrinkle
  • - + Anti-Pigmentation
  • - + Antioxidant
  • - + Hydrating
  • - + Regenerating
Nourishing

Nourishing skincare focuses on replenishing the skin with essential lipids, nutrients, and bioactive compounds to restore comfort, resilience, and optimal function. When the skin is depleted—whether through environmental stress, over-exfoliation, or natural ageing—it can become dry, fragile, and less able to protect itself. Nourishing formulations work to rebuild the lipid barrier using ingredients rich in fatty acids, vitamins, and antioxidants, helping to reinforce the skin’s structure while supporting repair and reducing moisture loss. By restoring what the skin lacks, this approach leaves it softer, stronger, and more supple.

Brightening (Energising)

Brightening skincare involves using active ingredients to boost your blood circulation, detoxification and cellular energy. Improved blood circulation brings more essential nutrients and oxygen to your skin, while detoxification helps eliminate cell waste and impurities that can make your skin look dull. Certain active ingredients also enhance your skin's metabolism and regeneration. These combined actions restore your skin's vitality and radiant appearance, giving you a fresh, energised complexion.

Plumping

Plumping involves using active ingredients to boost the production of key structural components like collagen, the dermal-epidermal junction and glycosaminoglycans (GAGs), giving your skin more volume and density. Collagen provides structural support and firmness, while the dermal-epidermal junction, a thin connective layer, ensures smooth, wrinkle-free skin by facilitating cell communication. GAGs, like hyaluronic acid, keep your skin hydrated and plump from within. By stimulating these components, active ingredients help restore your skin's plumpness and radiance.

Anti-Ageing (Glycation)

Combat Glycation and maintain firm, plump, and youthful skin with anti-glycation actives. Glycation is a unique phenomenon where excess sugar molecules from your diet bind to essential proteins like collagen and elastin. This binding process can affect the structural proteins in your skin, like collagen and elastin, which are crucial for maintaining its firmness and elasticity. This results in wrinkles, loss of elasticity, and can even trigger excess pigment production, leading to dark marks and dullness.

Prevent and reverse the effects of glycation by adopting a low-sugar diet and incorporating targeted skincare with anti-glycation actives. These specialised ingredients help prevent sugar from binding to your skin's proteins and repair existing damage, preserving your skin's health and radiance.

Anti-Wrinkle

Anti-wrinkle skincare is focused on both preventing and visibly reducing the formation of lines by targeting the structural and dynamic causes of wrinkles within the skin. Fine lines and deeper wrinkles develop as collagen and elastin decline, cell turnover slows and repeated facial movements create creases that become etched over time. Advanced formulations address these mechanisms through a combination of elastin-stimulating actives, smoothing peptides that help relax the appearance of expression lines, and deeply hydrating ingredients that plump the skin from within. By reinforcing the skin’s architecture while softening surface contractions and improving elasticity, anti-wrinkle skincare delivers a visibly smoother complexion.

Anti-Pigmentation

Dealing with pigmentation means targeting melanin overproduction to reduce dark spots and prevent new ones. Melanin production can be triggered by UV exposure, pollution, hormonal changes (like during pregnancy), and inflammation (from acne or cuts). This excess pigment is then transferred to surrounding cells in epidermis called keratinocytes, which then moves to the skin's surface, causing visible dark spots.

To treat hyperpigmentation, a personalised and consistent approach is needed. Our anti-pigmentation products include lightening agents to block tyrosinase (the enzyme that creates melanin), antioxidants to fight free radicals, and ingredients to speed up skin cell turnover, removing pigmented cells. Using broad-spectrum sun protection is crucial to prevent new pigmentation during treatment.

Antioxidant

Antioxidant skincare is dedicated to protecting the skin against oxidative stress—one of the primary drivers of premature ageing and cellular damage—while preserving overall skin integrity and vitality. These formulations rely on potent molecules such as vitamin C, vitamin E, and polyphenols, which neutralize free radicals generated by UV exposure and environmental aggressors before they can compromise cellular structures like lipids, proteins, and DNA. Beyond defence, many antioxidants also support repair processes and enhance collagen stability, contributing to improved firmness, brightness and resilience. The result is skin that is not only shielded from ongoing damage but maintained in a healthier, more luminous state over time.

Hydrating

Hydration is a fundamental part of healthy skincare, focusing on maintaining and restoring the skin’s water content. Well-hydrated skin appears plump, smooth and radiant, while dehydration can lead to dullness, tightness, fine lines and increased sensitivity.
Hydrating the skin can work through a fascinating mix of ingredients with different roles. Humectants like hyaluronic acid and glycerin act like water magnets, pulling water into the skin to instantly plump and smooth, while Natural Moisturizing Factors (NMFs)—such as urea, amino acids and sodium PCA—mimic the skin’s own hydration system, helping it hold onto water and stay balanced from within.
Adding humectants like hyaluronic acid to your routine will restore your skin's healthy glow, minimize fine lines, and provide a plumping effect.

Regenerating

Regenerating skincare actively stimulates the formation of new, healthier skin, working in alignment with the skin’s innate renewal processes. Central to this are growth factors—effectively encouraging the development of new skin tissue. Peptides complement this by acting as targeted messengers guiding the skin to rebuild with greater strength and structural integrity. Stem cell–derived actives further support this environment by delivering protective and regenerative signals that optimize cellular function and renewal. While these mechanisms are synonymous with advanced anti-ageing—improving firmness, elasticity and overall skin quality—they are equally valuable in addressing scarring, as they promote tissue repair, accelerate regeneration and help restore a smoother, more even skin surface.

  • - + Nourishing
  • - + Brightening (Energising)
  • - + Plumping
  • - + Anti-Ageing (Glycation)
  • - + Anti-Wrinkle
  • - + Anti-Pigmentation
  • - + Antioxidant
  • - + Hydrating
  • - + Regenerating

Active Ingredients

  • - + Low Molecular Weight Hyaluronic Acid
  • - + Onion, Myrrh & Myrtle Extract
  • - + Cucumber Extract
  • - + Witch Hazel & St John's Wort Extract
  • - + Prickly Pear Cactus Extract
  • - + NMF (Natural Moisturising Factors)
  • - + Alfafa Extract
  • - + Sophora Japonica Flower Extract
  • - + Centella Asiatica
  • - + Stabilised Vitamin C
Low Molecular Weight Hyaluronic Acid

Low Molecular Weight Hyaluronic Acid (LMW-HA) is a smaller, more penetrative form of hyaluronic acid. Unlike high molecular weight forms that primarily hydrate the skin’s surface, LMW-HA has the ability to penetrate deeper into the epidermis, where it attracts and binds water to maintain optimal moisture levels from within. This deep hydration helps improve skin elasticity, firmness and smoothness, while reducing the appearance of fine lines and dehydration-induced wrinkles. Additionally, it enhances overall suppleness, making the complexion look plumper and more resilient. It is ideal for dehydrated, dull or mature skin, and especially those in need of long-lasting hydration and improved texture.

Onion, Myrrh & Myrtle Extract

Unique to Biologique Recherche, the "Complex of Onion, Myrrh & Myrtle" has incredible astringent (tightening), purifying, antioxidant and soothing properties; which is very effective for an oilier complexion combatting sebum-regulation, acne or congestion.

Cucumber Extract

Cucumber Extract is rich in Vitamins and minerals. Having a variety of benefits, this ingredient is incredibly gentle and multi-faceted. It is softening and hydrating, as well as calming and refreshing. Furthermore, it also has some astringent and purifying properties, making it suitable for sensitive skins, oily skins and dehydrated skins.

Witch Hazel & St John's Wort Extract

Witch Hazel & St. John’s Wort Extract are rich in tannins and flavonoids, delivering powerful astringent benefits that help tighten tissue, refine pores, and smooth the skin’s surface. They are especially effective for regulating excess sebum while also soothing and calming damaged or irritated skin. While St. John’s Wort naturally contains hypericin, a compound with photosensitising potential, in cosmetic formulations it is carefully refined and used at safe levels, making it suitable for daily use.

Prickly Pear Cactus Extract

Prickly Pear Cactus Extract has strong water retention capabilities which have powerful nourishing benefits and therefore are extremely effective at combatting dry skin. Moreover, its piscidic acid content is adept at protecting the skin from oxidative stress, preventing premature cutaneous ageing. Lastly, it contains soothing benefits as it blocks stress markers in the skins' sensory nerve cells, which calms the skin.

NMF (Natural Moisturising Factors)

Natural Moisturising Factors are water-soluble substances which are naturally present in the epidermis. They are able to capture water and effectively hydrate the upper layers of the epidermis, making NMFs an incredibly hydrating ingredient for the skin.

Alfafa Extract

Alfafa Extract works very similarly to retinol as it promotes epidermal renewal by regulating how many new layers of skin can rebuild; aka "keratinocyte differentiation"; providing a more rejuvenated and brighter complexion. This ingredient also stimulates collagen synthesis, as well as preventing its breakdown (aka "collagenase"), and finally it supports the skin's metabolism which increases radiance in the skin.

Sophora Japonica Flower Extract

Sophora Japonica Flower Extract is rich in antioxidants and possesses properties that enhance cell communication, a process that becomes less efficient with age and exposure to free radicals. Efficient cell communication improves the effectiveness of skincare ingredients and delays premature ageing. Additionally, this extract stimulates the production of Collagen Type I, the predominant collagen in the skin, promoting a more plump and toned skin.

Centella Asiatica

Centella Asiatica is a powerful antioxidant which has immense anti-inflammatory, soothing and wound-healing benefits. Rich in chlorophyll, it is also extremely proficient at reducing redness. Also known as "Tiger Grass" as tigers were known to roll in it after having been wounded.

Stabilised Vitamin C

Stabilised vitamin C is a chemically modified derivative of Vitamin C engineered to maintain potency and resist oxidation caused by exposure to light, heat, and oxygen, offering enhanced stability and controlled release into the skin. Once absorbed, they function as potent antioxidants, neutralising free radicals generated by UV radiation and pollution to prevent oxidative stress and premature cellular ageing. Stabilised vitamin C also inhibits tyrosinase activity, reducing melanin synthesis and promoting a more even, luminous skin tone. Additionally, it stimulates collagen synthesis by supporting fibroblast activity, improving skin firmness and elasticity over time. Because of their lower irritation potential and greater formulation stability, these forms are accepted by most skin types; including sensitive, acne-prone, or reactive skin.

  • - + Low Molecular Weight Hyaluronic Acid
  • - + Onion, Myrrh & Myrtle Extract
  • - + Cucumber Extract
  • - + Witch Hazel & St John's Wort Extract
  • - + Prickly Pear Cactus Extract
  • - + NMF (Natural Moisturising Factors)
  • - + Alfafa Extract
  • - + Sophora Japonica Flower Extract
  • - + Centella Asiatica
  • - + Stabilised Vitamin C
The Biologique Recherche Proprietary Oxygenating Complex

Biologique Recherche's proprietary Oxygenating Complex is a powerful skincare ingredient known for its rejuvenating properties. It enhances cellular respiration and promotes better tissue oxygenation, which helps boost the efficacy of other active ingredients.

It contains perfluorodecalin, a compound renowned for its ability to transport oxygen. It stimulates cellular exchange to replenish oxygen-deprived skin, resulting in improved skin vitality and enhanced absorption of skincare products.

This advanced formulation is particularly suited to city workers, smokers and those with stressed or dull skin, leading to a more radiant and healthier complexion with boosted cellular function.

Clinical Proofs

EFFICACY TEST:
Test conducted on 21 subjects aged 41 to 75. Two scoring assessments, tactile (by a dermatologist) and visual (by
a clinician), were conducted at the beginning of the study and after 28 days of using the product twice daily.
- Skin appearance (tactile scoring):
AFTER 28 DAYS
Variation %
Hydration +186%
Softness +186%
Suppleness +184%
Nourishing effect +184%
Dehydration wrinkle appearance +163%
Smooth appearance of facial lines +158%
- Complexion appearance (visual scoring):
AFTER 28 DAYS
Variation %
Radiance +211%
Uniformity +267%

USAGE TEST:
Test conducted on 22 women aged 43 to 71 after using the product twice a day for 28 days.
- 100% of women said their skin was regenerated
- 100% of women said their skin was revitalised
- 100% of women said their skin was intensely moisturised
- 95% of women said their skin was smoothed
- 87% of women said their wrinkles were reduced
- 91% of women said their skin was firmer, more elastic
- 95% of women said their skin and more supple
- 96% of women said their skin was more radiant and their complexion was luminous
- 96% of women said signs of aging were reduced
- 100% of women said signs of fatigue were reduced

* The above information has been supplied to the Embassy of Beauty by the brand manufacturer. Embassy of Beauty takes no responsibility for these claimed studies and or results.

Spotlight

The Biologique Recherche Proprietary Oxygenating Complex

Biologique Recherche's proprietary Oxygenating Complex is a powerful skincare ingredient known for its rejuvenating properties. It enhances cellular respiration and promotes better tissue oxygenation, which helps boost the efficacy of other active ingredients.

It contains perfluorodecalin, a compound renowned for its ability to transport oxygen. It stimulates cellular exchange to replenish oxygen-deprived skin, resulting in improved skin vitality and enhanced absorption of skincare products.

This advanced formulation is particularly suited to city workers, smokers and those with stressed or dull skin, leading to a more radiant and healthier complexion with boosted cellular function.

Clinical Proofs

Clinical Proofs

EFFICACY TEST:
Test conducted on 21 subjects aged 41 to 75. Two scoring assessments, tactile (by a dermatologist) and visual (by
a clinician), were conducted at the beginning of the study and after 28 days of using the product twice daily.
- Skin appearance (tactile scoring):
AFTER 28 DAYS
Variation %
Hydration +186%
Softness +186%
Suppleness +184%
Nourishing effect +184%
Dehydration wrinkle appearance +163%
Smooth appearance of facial lines +158%
- Complexion appearance (visual scoring):
AFTER 28 DAYS
Variation %
Radiance +211%
Uniformity +267%

USAGE TEST:
Test conducted on 22 women aged 43 to 71 after using the product twice a day for 28 days.
- 100% of women said their skin was regenerated
- 100% of women said their skin was revitalised
- 100% of women said their skin was intensely moisturised
- 95% of women said their skin was smoothed
- 87% of women said their wrinkles were reduced
- 91% of women said their skin was firmer, more elastic
- 95% of women said their skin and more supple
- 96% of women said their skin was more radiant and their complexion was luminous
- 96% of women said signs of aging were reduced
- 100% of women said signs of fatigue were reduced

* The above information has been supplied to the Embassy of Beauty by the brand manufacturer. Embassy of Beauty takes no responsibility for these claimed studies and or results.

Why I love it

  • "The efficacy of Biologique Recherche relies not only on its science-driven approach to balancing and curing the skin, but on its prescriptive and tailored nature."

    X Natalie K-F

    Founder, Embassy of Beauty

  • Biologique Recherche Creme Grand Millesime 50ml
    Biologique Recherche

    Creme Grand Millesime

    £211

    The Biologique Recherche Creme Grand Millesime is a brightening and illuminating cream that revitalises, regenerates and hydrates the skin. It enhances the complexion and helps prevent signs of ageing.

    View product